<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">结合局部一致<br-fixation fixation-strength="2">性和低频振幅<br-fixation fixation-strength="3">探究躯体症状<br-fixation fixation-strength="4">障碍患者<br-edge>大脑自发性活动的改变
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">崔<br-fixation fixation-strength="2">阳<br-fixation fixation-strength="3">阳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">梁<br-fixation fixation-strength="2">怀<br-fixation fixation-strength="3">彬
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">朱<br-fixation fixation-strength="2">千
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">汤<br-fixation fixation-strength="2">伟
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">高<br-fixation fixation-strength="2">婷<br-fixation fixation-strength="3">婷
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">刘<br-fixation fixation-strength="2">建<br-fixation fixation-strength="3">仁
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">杜<br-fixation fixation-strength="2">小<br-fixation fixation-strength="3">霞
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">上海<br-fixation fixation-strength="2">体育<br-fixation fixation-strength="3">学院<br-fixation fixation-strength="4">心<br-edge>理学院,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海200438
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">上海交通<br-fixation fixation-strength="2">大学医学<br-fixation fixation-strength="3">院附属第<br-fixation fixation-strength="4">九人民<br-edge>医院神经内科,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海200011
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">华东师范<br-fixation fixation-strength="2">大学物理<br-fixation fixation-strength="3">与电子科<br-fixation fixation-strength="4">学<br-edge>学院物理系,<br-bold><br-fixation fixation-strength="1">上海<br-fixation fixation-strength="2">市磁<br-fixation fixation-strength="3">共振<br-fixation fixation-strength="4">重点<br-edge>实验室,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海200062
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1000-4556
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">波<br-fixation fixation-strength="2">谱<br-fixation fixation-strength="3">学<br-fixation fixation-strength="4">杂<br-edge>志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2022
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 39
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 1
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 64-71
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">症<br-fixation fixation-strength="4">状<br-edge>障碍(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">D)
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">局<br-fixation fixation-strength="2">部<br-fixation fixation-strength="3">一<br-fixation fixation-strength="4">致<br-edge>性
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">低<br-fixation fixation-strength="2">频<br-fixation fixation-strength="3">振<br-edge>幅(<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">L<br-fixation fixation-strength="3">F<br-edge>F)
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">功能<br-fixation fixation-strength="2">磁共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4"><br-edge>成像(<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-edge>I)
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">症<br-fixation fixation-strength="4">状<br-edge>障碍(<br-bold><br-fixation fixation-strength="1">so<br-fixation fixation-strength="2">ma<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4"><br-edge>ic <br-bold><br-fixation fixation-strength="1">sy<br-fixation fixation-strength="2">mp<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4"><br-edge>om <br-bold><br-fixation fixation-strength="1">di<br-fixation fixation-strength="2">so<br-fixation fixation-strength="3">rd<br-fixation fixation-strength="4"><br-edge>er,<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">D)<br-bold><br-fixation fixation-strength="1">是一<br-fixation fixation-strength="2">种常<br-fixation fixation-strength="3">见的<br-fixation fixation-strength="4">医<br-edge>学疾病,<br-bold><br-fixation fixation-strength="1">致病<br-fixation fixation-strength="2">原因<br-fixation fixation-strength="3">涉及<br-fixation fixation-strength="4"><br-edge>生物学、<br-bold><br-fixation fixation-strength="1">心理<br-fixation fixation-strength="2">学及<br-fixation fixation-strength="3">社会<br-fixation fixation-strength="4"><br-edge>因素.<br-bold><br-fixation fixation-strength="1">目前关<br-fixation fixation-strength="2">于SS<br-fixation fixation-strength="3">D的神<br-fixation fixation-strength="4">经机<br-edge>制知之甚少.<br-bold><br-fixation fixation-strength="1">本研究<br-fixation fixation-strength="2">通过静<br-fixation fixation-strength="3">息态功<br-fixation fixation-strength="4">能磁<br-edge>共振成像(<br-bold><br-fixation fixation-strength="1">fu<br-fixation fixation-strength="2">nc<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4">o<br-edge>nal <br-bold><br-fixation fixation-strength="1">ma<br-fixation fixation-strength="2">gn<br-fixation fixation-strength="3">et<br-fixation fixation-strength="4"><br-edge>ic <br-bold><br-fixation fixation-strength="1">re<br-fixation fixation-strength="2">so<br-fixation fixation-strength="3">na<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">im<br-fixation fixation-strength="2">ag<br-fixation fixation-strength="3">i<br-fixation fixation-strength="4"><br-edge>ng,<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-edge>I),<br-bold><br-fixation fixation-strength="1">结<br-fixation fixation-strength="2">合<br-fixation fixation-strength="3">低<br-fixation fixation-strength="4">频<br-edge>振幅(<br-bold><br-fixation fixation-strength="1">am<br-fixation fixation-strength="2">pl<br-fixation fixation-strength="3">it<br-fixation fixation-strength="4">u<br-edge>des <br-bold><br-fixation fixation-strength="1">o<br-fixation fixation-strength="2">f <br-bold><br-fixation fixation-strength="1">l<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">w-<br-bold><br-fixation fixation-strength="1">fr<br-fixation fixation-strength="2">eq<br-fixation fixation-strength="3">ue<br-fixation fixation-strength="4"><br-edge>ncy <br-bold><br-fixation fixation-strength="1">fl<br-fixation fixation-strength="2">uc<br-fixation fixation-strength="3">tu<br-fixation fixation-strength="4">at<br-edge>ion,<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">L<br-fixation fixation-strength="3">F<br-edge>F)<br-bold><br-fixation fixation-strength="1">和<br-fixation fixation-strength="2">局<br-fixation fixation-strength="3">部<br-fixation fixation-strength="4">一<br-edge>致性(<br-bold><br-fixation fixation-strength="1">re<br-fixation fixation-strength="2">gi<br-fixation fixation-strength="3">on<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">ho<br-fixation fixation-strength="2">mo<br-fixation fixation-strength="3">ge<br-fixation fixation-strength="4">ne<br-edge>ity,<br-bold><br-fixation fixation-strength="1">R<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">H<br-edge>o)<br-bold><br-fixation fixation-strength="1">分<br-fixation fixation-strength="2">析<br-fixation fixation-strength="3">探<br-edge>究45<br-bold><br-fixation fixation-strength="1">位S<br-fixation fixation-strength="2">SD<br-fixation fixation-strength="3">患<br-fixation fixation-strength="4"><br-edge>者和43<br-bold><br-fixation fixation-strength="1">位健康<br-fixation fixation-strength="2">对照自<br-fixation fixation-strength="3">发性脑<br-fixation fixation-strength="4">活动<br-edge>特征的区别.<br-bold><br-fixation fixation-strength="1">结<br-fixation fixation-strength="2">果<br-fixation fixation-strength="3">发<br-edge>现:<br-bold><br-fixation fixation-strength="1">与<br-fixation fixation-strength="2">对<br-fixation fixation-strength="3">照<br-fixation fixation-strength="4">组<br-edge>相比,<br-bold><br-fixation fixation-strength="1">SSD患<br-fixation fixation-strength="2">者右侧扣<br-fixation fixation-strength="3">带回中部<br-fixation fixation-strength="4">的Re<br-edge>Ho值显著升高,<br-bold><br-fixation fixation-strength="1">而<br-fixation fixation-strength="2">右<br-fixation fixation-strength="3">侧<br-fixation fixation-strength="4">楔<br-edge>前叶、<br-bold><br-fixation fixation-strength="1">左侧颞下<br-fixation fixation-strength="2">回延伸到<br-fixation fixation-strength="3">左侧颞中<br-fixation fixation-strength="4">回和<br-edge>左侧海马旁回、<br-bold><br-fixation fixation-strength="1">右侧脑<br-fixation fixation-strength="2">桥的R<br-fixation fixation-strength="3">eHo<br-fixation fixation-strength="4">值<br-edge>显著降低.<br-bold><br-fixation fixation-strength="1">同<br-fixation fixation-strength="2">时,<br-bold><br-fixation fixation-strength="1">SSD患<br-fixation fixation-strength="2">者扣带回<br-fixation fixation-strength="3">中部延伸<br-fixation fixation-strength="4">至<br-edge>左侧额中回、<br-bold><br-fixation fixation-strength="1">右侧<br-fixation fixation-strength="2">脑岛<br-fixation fixation-strength="3">延伸<br-fixation fixation-strength="4">至右<br-edge>侧额下回、<br-bold><br-fixation fixation-strength="1">左侧额中回<br-fixation fixation-strength="2">延伸至左侧<br-fixation fixation-strength="3">前扣带回的<br-fixation fixation-strength="4">ALF<br-edge>F值均显著升高.<br-bold><br-fixation fixation-strength="1">这些脑<br-fixation fixation-strength="2">区的脑<br-fixation fixation-strength="3">功能与<br-fixation fixation-strength="4"><br-edge>自我加工、<br-bold><br-fixation fixation-strength="1">情<br-fixation fixation-strength="2">绪<br-fixation fixation-strength="3">处<br-edge>理、<br-bold><br-fixation fixation-strength="1">身体<br-fixation fixation-strength="2">知觉<br-fixation fixation-strength="3">等<br-fixation fixation-strength="4"><br-edge>有关,<br-bold><br-fixation fixation-strength="1">与SS<br-fixation fixation-strength="2">D发病<br-fixation fixation-strength="3">机制有<br-fixation fixation-strength="4"><br-edge>重要联系.
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7106690812
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 3
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">国家<br-fixation fixation-strength="2">自然<br-fixation fixation-strength="3">科学<br-fixation fixation-strength="4">基金<br-edge>资助项目(81571658)。



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">躯体形式障<br-fixation fixation-strength="2">碍脑静息态<br-fixation fixation-strength="3">功能磁共振<br-fixation fixation-strength="4">成像<br-edge>的低频振幅研究
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">罗<br-fixation fixation-strength="2">为
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">戴<br-fixation fixation-strength="2">志<br-fixation fixation-strength="3">强
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">赵<br-fixation fixation-strength="2">明
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">张<br-fixation fixation-strength="2">扬
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">郭<br-fixation fixation-strength="2">俊<br-fixation fixation-strength="3">伟
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">何<br-fixation fixation-strength="2">梅
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">黎<br-fixation fixation-strength="2">海<br-fixation fixation-strength="3">涛
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">第三军<br-fixation fixation-strength="2">医大学<br-fixation fixation-strength="3">西南医<br-fixation fixation-strength="4"><br-edge>院放射科,<br-bold><br-fixation fixation-strength="1">重<br-fixation fixation-strength="2">庆400038
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">第三军<br-fixation fixation-strength="2">医大学<br-fixation fixation-strength="3">西南医<br-fixation fixation-strength="4">院<br-edge>神经外科,<br-bold><br-fixation fixation-strength="1">重<br-fixation fixation-strength="2">庆400038
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">第三军<br-fixation fixation-strength="2">医大学<br-fixation fixation-strength="3">西南医<br-fixation fixation-strength="4">院临<br-edge>床心理科,<br-bold><br-fixation fixation-strength="1">重<br-fixation fixation-strength="2">庆400038
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1000-5404
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">第三<br-fixation fixation-strength="2">军医<br-fixation fixation-strength="3">大学<br-fixation fixation-strength="4"><br-edge>学报
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2016
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 38
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 9
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 987-991
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">低<br-fixation fixation-strength="2">频<br-fixation fixation-strength="3">振<br-edge>幅
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">形<br-fixation fixation-strength="4">式<br-edge>障碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">静<br-fixation fixation-strength="2">息<br-fixation fixation-strength="3">态
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">功能<br-fixation fixation-strength="2">磁共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4"><br-edge>成像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的探讨<br-fixation fixation-strength="2">躯体形式<br-fixation fixation-strength="3">障碍脑静<br-fixation fixation-strength="4">息<br-edge>态低频振幅(<br-bold><br-fixation fixation-strength="1">am<br-fixation fixation-strength="2">pl<br-fixation fixation-strength="3">it<br-fixation fixation-strength="4"><br-edge>ude <br-bold><br-fixation fixation-strength="1">o<br-fixation fixation-strength="2">f <br-bold><br-fixation fixation-strength="1">l<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">w <br-bold><br-fixation fixation-strength="1">fr<br-fixation fixation-strength="2">eq<br-fixation fixation-strength="3">ue<br-fixation fixation-strength="4"><br-edge>ncy <br-bold><br-fixation fixation-strength="1">fl<br-fixation fixation-strength="2">uc<br-fixation fixation-strength="3">tu<br-fixation fixation-strength="4">at<br-edge>ion,<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">L<br-fixation fixation-strength="3">F<br-edge>F)<br-bold><br-fixation fixation-strength="1">改<br-fixation fixation-strength="2">变<br-fixation fixation-strength="3">特<br-edge>点。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法<br-fixation fixation-strength="3">纳<br-edge>入21<br-bold><br-fixation fixation-strength="1">例躯<br-fixation fixation-strength="2">体形<br-fixation fixation-strength="3">式<br-fixation fixation-strength="4"><br-edge>障碍(<br-bold><br-fixation fixation-strength="1">so<br-fixation fixation-strength="2">ma<br-fixation fixation-strength="3">to<br-fixation fixation-strength="4">f<br-edge>orm <br-bold><br-fixation fixation-strength="1">di<br-fixation fixation-strength="2">so<br-fixation fixation-strength="3">rd<br-fixation fixation-strength="4"><br-edge>ers,<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">F<br-fixation fixation-strength="3">D)<br-bold><br-fixation fixation-strength="1">患<br-fixation fixation-strength="2">者<br-fixation fixation-strength="3">和21<br-bold><br-fixation fixation-strength="1">例<br-fixation fixation-strength="2">年<br-fixation fixation-strength="3">龄、<br-bold><br-fixation fixation-strength="1">性<br-fixation fixation-strength="2">别、<br-bold><br-fixation fixation-strength="1">受教育<br-fixation fixation-strength="2">水平严<br-fixation fixation-strength="3">格匹配<br-fixation fixation-strength="4">的<br-edge>正常对照(<br-bold><br-fixation fixation-strength="1">n<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">r<br-fixation fixation-strength="4">m<br-edge>al <br-bold><br-fixation fixation-strength="1">co<br-fixation fixation-strength="2">nt<br-fixation fixation-strength="3">r<br-fixation fixation-strength="4"><br-edge>ol,<br-bold><br-fixation fixation-strength="1">N<br-fixation fixation-strength="2">C),<br-bold><br-fixation fixation-strength="1">使<br-fixation fixation-strength="2">用3.0<br-bold><br-fixation fixation-strength="1">T磁<br-fixation fixation-strength="2">共振<br-fixation fixation-strength="3">扫描<br-fixation fixation-strength="4">仪<br-edge>采集T2<br-bold><br-fixation fixation-strength="1">W<br-fixation fixation-strength="2">I、<br-bold><br-fixation fixation-strength="1">T1<br-bold><br-fixation fixation-strength="1">WI结<br-fixation fixation-strength="2">构像及<br-fixation fixation-strength="3">静息态<br-fixation fixation-strength="4">功<br-edge>能像数据。<br-bold><br-fixation fixation-strength="1">对两<br-fixation fixation-strength="2">组受<br-fixation fixation-strength="3">试者<br-fixation fixation-strength="4">的A<br-edge>LFF <br-bold><br-fixation fixation-strength="1">ma<br-fixation fixation-strength="2">p行<br-fixation fixation-strength="3">组内<br-fixation fixation-strength="4">和组<br-edge>间比较,<br-bold><br-fixation fixation-strength="1">并采<br-fixation fixation-strength="2">用A<br-fixation fixation-strength="3">lp<br-fixation fixation-strength="4"><br-edge>ha <br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">m(<br-bold><br-fixation fixation-strength="1">P40)<br-bold><br-fixation fixation-strength="1">进行<br-fixation fixation-strength="2">多重<br-fixation fixation-strength="3">比较<br-fixation fixation-strength="4"><br-edge>校正。<br-bold><br-fixation fixation-strength="1">然后提取差<br-fixation fixation-strength="2">异脑区的A<br-fixation fixation-strength="3">LFF值与<br-fixation fixation-strength="4">临床数<br-edge>据进行相关性分析。<br-bold><br-fixation fixation-strength="1">结果<br-fixation fixation-strength="2">与N<br-fixation fixation-strength="3">C组<br-fixation fixation-strength="4"><br-edge>比较,<br-bold><br-fixation fixation-strength="1">SFD<br-fixation fixation-strength="2">组AL<br-fixation fixation-strength="3">FF值<br-fixation fixation-strength="4">增高<br-edge>的脑区有:<br-bold><br-fixation fixation-strength="1">双<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">前<br-fixation fixation-strength="4">额<br-edge>叶、<br-bold><br-fixation fixation-strength="1">双<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">前<br-fixation fixation-strength="4">扣<br-edge>带回；<br-bold><br-fixation fixation-strength="1">AL<br-fixation fixation-strength="2">FF<br-fixation fixation-strength="3">值减<br-fixation fixation-strength="4">低的<br-edge>脑区有:<br-bold><br-fixation fixation-strength="1">右侧<br-fixation fixation-strength="2">颞叶<br-fixation fixation-strength="3">颞<br-fixation fixation-strength="4"><br-edge>中回、<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">岛<br-edge>叶、<br-bold><br-fixation fixation-strength="1">左侧旁<br-fixation fixation-strength="2">中央小<br-fixation fixation-strength="3">叶双侧<br-fixation fixation-strength="4"><br-edge>中央后回。<br-bold><br-fixation fixation-strength="1">SFD<br-fixation fixation-strength="2">组蒙特<br-fixation fixation-strength="3">利尔认<br-fixation fixation-strength="4">知<br-edge>评估量表(<br-bold><br-fixation fixation-strength="1">M<br-fixation fixation-strength="2">o <br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">量<br-edge>表)<br-bold><br-fixation fixation-strength="1">评分与左<br-fixation fixation-strength="2">侧腹内侧<br-fixation fixation-strength="3">前额叶A<br-fixation fixation-strength="4">LFF<br-edge>值呈显著负相关(<br-bold><br-fixation fixation-strength="1">r=-0.564,<br-bold><br-fixation fixation-strength="1">P=0.008),<br-bold><br-fixation fixation-strength="1">症<br-fixation fixation-strength="2">状<br-fixation fixation-strength="3">自<br-fixation fixation-strength="4">评<br-edge>量表(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">C<br-fixation fixation-strength="3">L-90)<br-bold><br-fixation fixation-strength="1">评分与左<br-fixation fixation-strength="2">侧岛叶A<br-fixation fixation-strength="3">LFF值<br-fixation fixation-strength="4">呈<br-edge>显著负相关(<br-bold><br-fixation fixation-strength="1">r=-0.505,<br-bold><br-fixation fixation-strength="1">P=0.020),<br-bold><br-fixation fixation-strength="1">病程与右<br-fixation fixation-strength="2">侧颞叶A<br-fixation fixation-strength="3">LFF值<br-fixation fixation-strength="4">呈<br-edge>显著负相关(<br-bold><br-fixation fixation-strength="1">r=-0.514,<br-bold><br-fixation fixation-strength="1">P=0.017)。<br-bold><br-fixation fixation-strength="1">结<br-fixation fixation-strength="2">论 <br-bold><br-fixation fixation-strength="1">SFD患<br-fixation fixation-strength="2">者脑静息<br-fixation fixation-strength="3">态神经元<br-fixation fixation-strength="4">自发活<br-edge>动存在广泛改变,<br-bold><br-fixation fixation-strength="1">这些异常活<br-fixation fixation-strength="2">动可部分阐<br-fixation fixation-strength="3">释躯体形式<br-fixation fixation-strength="4">障碍<br-edge>的神经生理基础。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=668692027
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 4
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">国家<br-fixation fixation-strength="2">自然<br-fixation fixation-strength="3">科学<br-fixation fixation-strength="4">基金<br-edge>面上项目(81171283)~~



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">基于低频振幅<br-fixation fixation-strength="2">分数和度中心<br-fixation fixation-strength="3">性的躯体症状<br-fixation fixation-strength="4">障碍静息<br-edge>态回行功能成像研究
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">崔<br-fixation fixation-strength="2">阳<br-fixation fixation-strength="3">阳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">梁<br-fixation fixation-strength="2">怀<br-fixation fixation-strength="3">彬
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">朱<br-fixation fixation-strength="2">千
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">汤<br-fixation fixation-strength="2">伟
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">高<br-fixation fixation-strength="2">婷<br-fixation fixation-strength="3">婷
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">刘<br-fixation fixation-strength="2">建<br-fixation fixation-strength="3">仁
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">杜<br-fixation fixation-strength="2">小<br-fixation fixation-strength="3">霞
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">华东师<br-fixation fixation-strength="2">范大学<br-fixation fixation-strength="3">物理与<br-fixation fixation-strength="4">电子<br-edge>学院物理系,<br-bold><br-fixation fixation-strength="1">上海<br-fixation fixation-strength="2">市磁<br-fixation fixation-strength="3">共振<br-fixation fixation-strength="4">重点<br-edge>实验室,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海200062
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">上海交通<br-fixation fixation-strength="2">大学医学<br-fixation fixation-strength="3">院附属第<br-fixation fixation-strength="4">九人民<br-edge>医院神经内科,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海200011
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1674-8034
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">磁<br-fixation fixation-strength="2">共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4">成<br-edge>像
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2021
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 12
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 7
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 51-54
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">躯体<br-fixation fixation-strength="2">化症<br-fixation fixation-strength="3">状<br-fixation fixation-strength="4"><br-edge>障碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">低<br-fixation fixation-strength="2">频<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4">幅<br-edge>分数
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">度<br-fixation fixation-strength="2">中<br-fixation fixation-strength="3">心<br-edge>性
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">功能<br-fixation fixation-strength="2">磁共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4"><br-edge>成像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的运<br-fixation fixation-strength="2">用静息<br-fixation fixation-strength="3">态功能<br-fixation fixation-strength="4">磁<br-edge>共振成像(<br-bold><br-fixation fixation-strength="1">re<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">i<br-fixation fixation-strength="4"><br-edge>ng-<br-bold><br-fixation fixation-strength="1">s<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">a<br-fixation fixation-strength="4">t<br-edge>e <br-bold><br-fixation fixation-strength="1">fu<br-fixation fixation-strength="2">nc<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4">o<br-edge>nal <br-bold><br-fixation fixation-strength="1">ma<br-fixation fixation-strength="2">gn<br-fixation fixation-strength="3">et<br-fixation fixation-strength="4"><br-edge>ic <br-bold><br-fixation fixation-strength="1">re<br-fixation fixation-strength="2">so<br-fixation fixation-strength="3">na<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">im<br-fixation fixation-strength="2">ag<br-fixation fixation-strength="3">i<br-fixation fixation-strength="4"><br-edge>ng,<br-bold><br-fixation fixation-strength="1">r<br-fixation fixation-strength="2">s-<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-edge>I)<br-bold><br-fixation fixation-strength="1">并结<br-fixation fixation-strength="2">合低<br-fixation fixation-strength="3">频振<br-fixation fixation-strength="4"><br-edge>幅分数(<br-bold><br-fixation fixation-strength="1">fr<br-fixation fixation-strength="2">ac<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4">o<br-edge>nal <br-bold><br-fixation fixation-strength="1">am<br-fixation fixation-strength="2">pl<br-fixation fixation-strength="3">it<br-fixation fixation-strength="4"><br-edge>ude <br-bold><br-fixation fixation-strength="1">o<br-fixation fixation-strength="2">f <br-bold><br-fixation fixation-strength="1">l<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">w-<br-bold><br-fixation fixation-strength="1">fr<br-fixation fixation-strength="2">eq<br-fixation fixation-strength="3">ue<br-fixation fixation-strength="4"><br-edge>ncy <br-bold><br-fixation fixation-strength="1">fl<br-fixation fixation-strength="2">uc<br-fixation fixation-strength="3">ta<br-fixation fixation-strength="4">t<br-edge>ion,<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">L<br-fixation fixation-strength="4">F<br-edge>F)<br-bold><br-fixation fixation-strength="1">和<br-fixation fixation-strength="2">度<br-fixation fixation-strength="3">中<br-fixation fixation-strength="4">心<br-edge>性(<br-bold><br-fixation fixation-strength="1">d<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">r<br-edge>ee <br-bold><br-fixation fixation-strength="1">ce<br-fixation fixation-strength="2">nt<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4">l<br-edge>ity,<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">C)<br-bold><br-fixation fixation-strength="1">来探<br-fixation fixation-strength="2">讨躯<br-fixation fixation-strength="3">体症<br-fixation fixation-strength="4"><br-edge>状障碍(<br-bold><br-fixation fixation-strength="1">so<br-fixation fixation-strength="2">ma<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4"><br-edge>ic <br-bold><br-fixation fixation-strength="1">sy<br-fixation fixation-strength="2">mp<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4"><br-edge>om <br-bold><br-fixation fixation-strength="1">di<br-fixation fixation-strength="2">so<br-fixation fixation-strength="3">rd<br-fixation fixation-strength="4"><br-edge>er,<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">D)<br-bold><br-fixation fixation-strength="1">患者是<br-fixation fixation-strength="2">否存在<br-fixation fixation-strength="3">某些脑<br-fixation fixation-strength="4">功能<br-edge>上的异常,<br-bold><br-fixation fixation-strength="1">从而为躯<br-fixation fixation-strength="2">体症状障<br-fixation fixation-strength="3">碍的临床<br-fixation fixation-strength="4">诊疗<br-edge>提供参考信息。<br-bold><br-fixation fixation-strength="1">材<br-fixation fixation-strength="2">料<br-fixation fixation-strength="3">与<br-fixation fixation-strength="4">方<br-edge>法45<br-bold><br-fixation fixation-strength="1">例右<br-fixation fixation-strength="2">利手<br-fixation fixation-strength="3">SS<br-fixation fixation-strength="4">D<br-edge>患者和43<br-bold><br-fixation fixation-strength="1">名右利手<br-fixation fixation-strength="2">健康对照<br-fixation fixation-strength="3">组参与静<br-fixation fixation-strength="4">息<br-edge>态磁共振扫描,<br-bold><br-fixation fixation-strength="1">fALFF和<br-fixation fixation-strength="2">DC分析探测<br-fixation fixation-strength="3">SSD患者静<br-fixation fixation-strength="4">息态下自<br-edge>发性脑活动上的特征。<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">P<br-fixation fixation-strength="3">M12<br-bold><br-fixation fixation-strength="1">软件<br-fixation fixation-strength="2">用于<br-fixation fixation-strength="3">磁共<br-fixation fixation-strength="4">振数<br-edge>据的分析,<br-bold><br-fixation fixation-strength="1">组分析采用<br-fixation fixation-strength="2">双样本t检<br-fixation fixation-strength="3">验fALF<br-fixation fixation-strength="4">F和DC统<br-edge>计阈值为体素水平P<br-fixation fixation-strength="1">团块<br-fixation fixation-strength="2">水平<br-fixation fixation-strength="3">经过<br-fixation fixation-strength="4">fa<br-edge>mily <br-bold><br-fixation fixation-strength="1">w<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">s<br-edge>e <br-bold><br-fixation fixation-strength="1">e<br-fixation fixation-strength="2">r<br-fixation fixation-strength="3">r<br-fixation fixation-strength="4">o<br-edge>r(<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">W<br-fixation fixation-strength="3">E)<br-bold><br-fixation fixation-strength="1">校<br-fixation fixation-strength="2">正,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">且<br-fixation fixation-strength="2">大<br-fixation fixation-strength="3">于10<br-bold><br-fixation fixation-strength="1">个体<br-fixation fixation-strength="2">素的<br-fixation fixation-strength="3">团块<br-fixation fixation-strength="4">将<br-edge>被报道。<br-bold><br-fixation fixation-strength="1">结果静息<br-fixation fixation-strength="2">态脑功能<br-fixation fixation-strength="3">结果显示<br-fixation fixation-strength="4">SSD<br-edge>患者在边缘叶、<br-bold><br-fixation fixation-strength="1">丘<br-fixation fixation-strength="2">脑<br-fixation fixation-strength="3">处(<br-bold><br-fixation fixation-strength="1">t=4.91)<br-bold><br-fixation fixation-strength="1">fAL<br-fixation fixation-strength="2">FF值<br-fixation fixation-strength="3">显著高<br-fixation fixation-strength="4">于健<br-edge>康对照组。<br-bold><br-fixation fixation-strength="1">SS<br-fixation fixation-strength="2">D患<br-fixation fixation-strength="3">者在<br-fixation fixation-strength="4"><br-edge>额叶、<br-bold><br-fixation fixation-strength="1">扣<br-fixation fixation-strength="2">带<br-fixation fixation-strength="3">回(<br-bold><br-fixation fixation-strength="1">t=5.20)<br-bold><br-fixation fixation-strength="1">的DC<br-fixation fixation-strength="2">值显著<br-fixation fixation-strength="3">低于健<br-fixation fixation-strength="4"><br-edge>康对照组。<br-bold><br-fixation fixation-strength="1">结论这些<br-fixation fixation-strength="2">异常的区<br-fixation fixation-strength="3">域可能与<br-fixation fixation-strength="4">SSD<br-edge>的发病机理有关,<br-bold><br-fixation fixation-strength="1">这些区域<br-fixation fixation-strength="2">的功能异<br-fixation fixation-strength="3">常可能会<br-fixation fixation-strength="4">导致<br-edge>个体情绪处理、<br-bold><br-fixation fixation-strength="1">自我感<br-fixation fixation-strength="2">觉和身<br-fixation fixation-strength="3">体知觉<br-fixation fixation-strength="4">功<br-edge>能的异常。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7105148104
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 7
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">国家<br-fixation fixation-strength="2">自然<br-fixation fixation-strength="3">科学<br-fixation fixation-strength="4"><br-edge>基金(<br-bold><br-fixation fixation-strength="1">编<br-fixation fixation-strength="2">号:81571658)。



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">形<br-fixation fixation-strength="4">式<br-edge>障碍35<br-bold><br-fixation fixation-strength="1">例S<br-fixation fixation-strength="2">PE<br-fixation fixation-strength="3">CT<br-fixation fixation-strength="4"><br-edge>研究
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">吴<br-fixation fixation-strength="2">皓
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">楼<br-fixation fixation-strength="2">岑
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">黄<br-fixation fixation-strength="2">中<br-fixation fixation-strength="3">柯
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">张<br-fixation fixation-strength="2">大<br-fixation fixation-strength="3">平
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">浙江大学医<br-fixation fixation-strength="2">学院附属邵<br-fixation fixation-strength="3">逸夫医院临<br-fixation fixation-strength="4">床医学三系<br-edge>神经精神病学教研室,310016
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">浙江大学<br-fixation fixation-strength="2">医学院附<br-fixation fixation-strength="3">属邵逸夫<br-fixation fixation-strength="4">医<br-edge>院核医学科,310016
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1002-0829
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海<br-fixation fixation-strength="3">精<br-fixation fixation-strength="4">神<br-edge>医学
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2004
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 16
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 6
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 324-326
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">形<br-fixation fixation-strength="4">式<br-edge>障碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">P<br-fixation fixation-strength="3">E<br-fixation fixation-strength="4">C<br-edge>T
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">脑<br-fixation fixation-strength="2">血<br-fixation fixation-strength="3">流<br-fixation fixation-strength="4">灌<br-edge>注
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">放射<br-fixation fixation-strength="2">性核<br-fixation fixation-strength="3">素<br-fixation fixation-strength="4"><br-edge>显像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目<br-fixation fixation-strength="2">的　<br-bold><br-fixation fixation-strength="1">探讨躯体<br-fixation fixation-strength="2">形式障碍<br-fixation fixation-strength="3">脑灌注特<br-fixation fixation-strength="4">点<br-edge>与潜在意义。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法　<br-bold><br-fixation fixation-strength="1">开放<br-fixation fixation-strength="2">性收<br-fixation fixation-strength="3">集门<br-fixation fixation-strength="4">诊和<br-edge>住院诊断 <br-bold><br-fixation fixation-strength="1">为躯<br-fixation fixation-strength="2">体形<br-fixation fixation-strength="3">式障<br-fixation fixation-strength="4"><br-edge>碍病人35<br-bold><br-fixation fixation-strength="1">例；<br-bold><br-fixation fixation-strength="1">进<br-fixation fixation-strength="2">行99<br-bold><br-fixation fixation-strength="1">m<br-fixation fixation-strength="2">T<br-fixation fixation-strength="3">c <br-bold><br-fixation fixation-strength="1">双<br-fixation fixation-strength="2">半<br-fixation fixation-strength="3">胱<br-fixation fixation-strength="4">乙<br-edge>脂(<br-bold><br-fixation fixation-strength="1">E<br-fixation fixation-strength="2">C<br-fixation fixation-strength="3">D)<br-bold><br-fixation fixation-strength="1">单光子<br-fixation fixation-strength="2">发射型<br-fixation fixation-strength="3">计算机<br-fixation fixation-strength="4"><br-edge>断层显像(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">P<br-fixation fixation-strength="3">E<br-fixation fixation-strength="4">C<br-edge>T)<br-bold><br-fixation fixation-strength="1">脑<br-fixation fixation-strength="2">血 <br-bold><br-fixation fixation-strength="1">流<br-fixation fixation-strength="2">灌<br-fixation fixation-strength="3">注(<br-bold><br-fixation fixation-strength="1">r<br-fixation fixation-strength="2">C<br-fixation fixation-strength="3">B<br-edge>F)<br-bold><br-fixation fixation-strength="1">断<br-fixation fixation-strength="2">层<br-fixation fixation-strength="3">显<br-edge>像,<br-bold><br-fixation fixation-strength="1">半定<br-fixation fixation-strength="2">量测<br-fixation fixation-strength="3">定r<br-fixation fixation-strength="4"><br-edge>CBF。<br-bold><br-fixation fixation-strength="1">结<br-fixation fixation-strength="2">果　35<br-bold><br-fixation fixation-strength="1">例躯体形<br-fixation fixation-strength="2">式障碍病<br-fixation fixation-strength="3">人均出现<br-fixation fixation-strength="4">有<br-edge>不同部位的脑 <br-bold><br-fixation fixation-strength="1">低<br-fixation fixation-strength="2">灌<br-fixation fixation-strength="3">注<br-fixation fixation-strength="4">现<br-edge>象；<br-bold><br-fixation fixation-strength="1">具<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">为<br-fixation fixation-strength="4">右<br-edge>额叶(13<br-bold><br-fixation fixation-strength="1">例,37%),<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">额<br-fixation fixation-strength="3">叶(11<br-bold><br-fixation fixation-strength="1">例,31%),<br-bold><br-fixation fixation-strength="1">右<br-fixation fixation-strength="2">颞<br-fixation fixation-strength="3">叶(13<br-bold><br-fixation fixation-strength="1">例,37%),<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">颞<br-fixation fixation-strength="3">叶(11<br-bold><br-fixation fixation-strength="1">例, 31%),<br-bold><br-fixation fixation-strength="1">右<br-fixation fixation-strength="2">顶<br-fixation fixation-strength="3">叶(11<br-bold><br-fixation fixation-strength="1">例,31%),<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">顶<br-fixation fixation-strength="3">叶(4<br-bold><br-fixation fixation-strength="1">例,11%),<br-bold><br-fixation fixation-strength="1">右<br-fixation fixation-strength="2">基<br-fixation fixation-strength="3">底<br-edge>节(14<br-bold><br-fixation fixation-strength="1">例,40%),<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">基<br-fixation fixation-strength="3">底<br-edge>节(17<br-bold><br-fixation fixation-strength="1">例,49%),<br-bold><br-fixation fixation-strength="1">右<br-fixation fixation-strength="2">丘 <br-bold><br-fixation fixation-strength="1">脑(1<br-bold><br-fixation fixation-strength="1">例,3%),<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">丘<br-fixation fixation-strength="3">脑(1<br-bold><br-fixation fixation-strength="1">例,3%),<br-bold><br-fixation fixation-strength="1">盐酸<br-fixation fixation-strength="2">文拉<br-fixation fixation-strength="3">法辛<br-fixation fixation-strength="4"><br-edge>治疗2<br-bold><br-fixation fixation-strength="1">周后不<br-fixation fixation-strength="2">同部位<br-fixation fixation-strength="3">脑血流<br-fixation fixation-strength="4">低灌注<br-edge>均明显改善,<br-bold><br-fixation fixation-strength="1">差<br-fixation fixation-strength="2">异 <br-bold><br-fixation fixation-strength="1">有<br-fixation fixation-strength="2">显<br-fixation fixation-strength="3">著<br-edge>性(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">结<br-fixation fixation-strength="2">论　<br-bold><br-fixation fixation-strength="1">躯体形式<br-fixation fixation-strength="2">障碍不同<br-fixation fixation-strength="3">临床表现<br-fixation fixation-strength="4">相<br-edge>应呈现额叶、<br-bold><br-fixation fixation-strength="1">基<br-fixation fixation-strength="2">底<br-fixation fixation-strength="3">节、<br-bold><br-fixation fixation-strength="1">颞<br-fixation fixation-strength="2">叶、<br-bold><br-fixation fixation-strength="1">顶<br-fixation fixation-strength="2">叶<br-fixation fixation-strength="3">不<br-fixation fixation-strength="4">同<br-edge>区域 <br-bold><br-fixation fixation-strength="1">脑<br-fixation fixation-strength="2">血<br-fixation fixation-strength="3">流<br-fixation fixation-strength="4">低<br-edge>灌注,<br-bold><br-fixation fixation-strength="1">治疗<br-fixation fixation-strength="2">后明<br-fixation fixation-strength="3">显<br-fixation fixation-strength="4"><br-edge>改善。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=12023802
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 8



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">持续性躯体<br-fixation fixation-strength="2">形式疼痛障<br-fixation fixation-strength="3">碍局部一致<br-fixation fixation-strength="4">性脑<br-edge>功能磁共振研究
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">刘<br-fixation fixation-strength="2">渠
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">陈<br-fixation fixation-strength="2">康<br-fixation fixation-strength="3">宁
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">王<br-fixation fixation-strength="2">健
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">李<br-fixation fixation-strength="2">敏
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">第三军<br-fixation fixation-strength="2">医大学<br-fixation fixation-strength="3">西南医<br-fixation fixation-strength="4">院<br-edge>神经内科,<br-bold><br-fixation fixation-strength="1">重<br-fixation fixation-strength="2">庆400038
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">第三军<br-fixation fixation-strength="2">医大学<br-fixation fixation-strength="3">西南医<br-fixation fixation-strength="4"><br-edge>院放射科,<br-bold><br-fixation fixation-strength="1">重<br-fixation fixation-strength="2">庆400038
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">第三军<br-fixation fixation-strength="2">医大学<br-fixation fixation-strength="3">护理学<br-fixation fixation-strength="4">院心<br-edge>理教研室,<br-bold><br-fixation fixation-strength="1">重<br-fixation fixation-strength="2">庆400038
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1671-8348
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">重<br-fixation fixation-strength="2">庆<br-fixation fixation-strength="3">医<br-edge>学
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2016
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 45
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 31
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 4369-4371+4374
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">持续<br-fixation fixation-strength="2">性躯<br-fixation fixation-strength="3">体形<br-fixation fixation-strength="4">式疼<br-edge>痛障碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">局<br-fixation fixation-strength="2">部<br-fixation fixation-strength="3">一<br-fixation fixation-strength="4">致<br-edge>性
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">功能<br-fixation fixation-strength="2">磁共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4"><br-edge>成像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的采<br-fixation fixation-strength="2">用静息<br-fixation fixation-strength="3">态功能<br-fixation fixation-strength="4">磁共振<br-edge>局部一致性(<br-bold><br-fixation fixation-strength="1">R<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">H<br-edge>o)<br-bold><br-fixation fixation-strength="1">技<br-fixation fixation-strength="2">术,<br-bold><br-fixation fixation-strength="1">观察持<br-fixation fixation-strength="2">续性躯<br-fixation fixation-strength="3">体形式<br-fixation fixation-strength="4"><br-edge>疼痛障碍(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">P<br-edge>D)<br-bold><br-fixation fixation-strength="1">患者<br-fixation fixation-strength="2">脑局<br-fixation fixation-strength="3">部R<br-fixation fixation-strength="4">e<br-edge>Ho值。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法<br-fixation fixation-strength="3">纳<br-edge>入21<br-bold><br-fixation fixation-strength="1">例以头<br-fixation fixation-strength="2">痛为主<br-fixation fixation-strength="3">要症状<br-fixation fixation-strength="4">的PS<br-edge>PD患者和17<br-bold><br-fixation fixation-strength="1">例<br-fixation fixation-strength="2">年<br-fixation fixation-strength="3">龄、<br-bold><br-fixation fixation-strength="1">性别<br-fixation fixation-strength="2">相匹<br-fixation fixation-strength="3">配的<br-fixation fixation-strength="4">健康<br-edge>对照者,<br-bold><br-fixation fixation-strength="1">所有被<br-fixation fixation-strength="2">试者行<br-fixation fixation-strength="3">静息态<br-fixation fixation-strength="4">功<br-edge>能磁共振,<br-bold><br-fixation fixation-strength="1">对磁共振<br-fixation fixation-strength="2">数据进行<br-fixation fixation-strength="3">分析得到<br-fixation fixation-strength="4">R<br-edge>eHo结果,<br-bold><br-fixation fixation-strength="1">然后对比<br-fixation fixation-strength="2">PSPD<br-fixation fixation-strength="3">患者组与<br-fixation fixation-strength="4">健康<br-edge>对照组的差异。<br-bold><br-fixation fixation-strength="1">结果<br-fixation fixation-strength="2">与健<br-fixation fixation-strength="3">康对<br-fixation fixation-strength="4">照<br-edge>组比较,<br-bold><br-fixation fixation-strength="1">PSP<br-fixation fixation-strength="2">D患者<br-fixation fixation-strength="3">双侧额<br-fixation fixation-strength="4">叶Re<br-edge>Ho值升高,<br-bold><br-fixation fixation-strength="1">而<br-fixation fixation-strength="2">双<br-fixation fixation-strength="3">侧<br-fixation fixation-strength="4">枕<br-edge>叶、<br-bold><br-fixation fixation-strength="1">双<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">直<br-edge>回、<br-bold><br-fixation fixation-strength="1">右<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">小<br-fixation fixation-strength="4">脑<br-edge>后叶、<br-bold><br-fixation fixation-strength="1">右侧<br-fixation fixation-strength="2">中央<br-fixation fixation-strength="3">旁<br-fixation fixation-strength="4"><br-edge>小叶、<br-bold><br-fixation fixation-strength="1">左侧<br-fixation fixation-strength="2">颞中<br-fixation fixation-strength="3">回R<br-fixation fixation-strength="4">eH<br-edge>o值降低(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">结论PSP<br-fixation fixation-strength="2">D患者相关<br-fixation fixation-strength="3">脑区神经元<br-fixation fixation-strength="4">活动<br-edge>一致性存在改变,<br-bold><br-fixation fixation-strength="1">这种改变可<br-fixation fixation-strength="2">能是导致P<br-fixation fixation-strength="3">SPD患者<br-fixation fixation-strength="4">发病<br-edge>的相关因素之一。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=670550253
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 1



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">静息态功能<br-fixation fixation-strength="2">磁共振在躯<br-fixation fixation-strength="3">体症状障碍<br-fixation fixation-strength="4">患者诊<br-edge>断中的研究进展
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">温<br-fixation fixation-strength="2">雪<br-fixation fixation-strength="3">婷
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">强<br-fixation fixation-strength="2">金<br-fixation fixation-strength="3">伟
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">复旦大<br-fixation fixation-strength="2">学附属<br-fixation fixation-strength="3">金山医<br-fixation fixation-strength="4"><br-edge>院放射科
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1006-5741
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">中国<br-fixation fixation-strength="2">医学<br-fixation fixation-strength="3">计算<br-fixation fixation-strength="4">机成<br-edge>像杂志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2022
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 28
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 1
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 104-107
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">症<br-fixation fixation-strength="4">状<br-edge>障碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">功能<br-fixation fixation-strength="2">磁共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4"><br-edge>成像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">静<br-fixation fixation-strength="2">息<br-fixation fixation-strength="3">态
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">症<br-fixation fixation-strength="4">状<br-edge>障碍(<br-bold><br-fixation fixation-strength="1">so<br-fixation fixation-strength="2">ma<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4"><br-edge>ic <br-bold><br-fixation fixation-strength="1">sy<br-fixation fixation-strength="2">mp<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4"><br-edge>om <br-bold><br-fixation fixation-strength="1">di<br-fixation fixation-strength="2">so<br-fixation fixation-strength="3">rd<br-fixation fixation-strength="4"><br-edge>er,<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">D)<br-bold><br-fixation fixation-strength="1">患者早期<br-fixation fixation-strength="2">往往就诊<br-fixation fixation-strength="3">于各大综<br-fixation fixation-strength="4">合医院<br-edge>普通或专科门诊,<br-bold><br-fixation fixation-strength="1">但其<br-fixation fixation-strength="2">识别<br-fixation fixation-strength="3">率却<br-fixation fixation-strength="4"><br-edge>很低。<br-bold><br-fixation fixation-strength="1">近<br-fixation fixation-strength="2">年<br-fixation fixation-strength="3">来,<br-bold><br-fixation fixation-strength="1">许多无创性<br-fixation fixation-strength="2">神经影像新<br-fixation fixation-strength="3">技术已用于<br-fixation fixation-strength="4">SSD患者<br-edge>脑结构和功能的研究,<br-bold><br-fixation fixation-strength="1">从而探<br-fixation fixation-strength="2">明其潜<br-fixation fixation-strength="3">在的病<br-fixation fixation-strength="4">理生<br-edge>理学机制。<br-bold><br-fixation fixation-strength="1">本文就静息<br-fixation fixation-strength="2">态功能磁共<br-fixation fixation-strength="3">振成像在S<br-fixation fixation-strength="4">SD方<br-edge>面的研究作一综述,<br-bold><br-fixation fixation-strength="1">旨在提高<br-fixation fixation-strength="2">影像科和<br-fixation fixation-strength="3">非精神科<br-fixation fixation-strength="4">医师对<br-edge>这一疾病的识别。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7106800828
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 4



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">躯体形式<br-fixation fixation-strength="2">障碍的神<br-fixation fixation-strength="3">经解剖学<br-fixation fixation-strength="4">及神经<br-edge>影像学研究进展
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">程<br-fixation fixation-strength="2">晓<br-fixation fixation-strength="3">阳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">王<br-fixation fixation-strength="2">俭
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">郑州大<br-fixation fixation-strength="2">学附属<br-fixation fixation-strength="3">洛阳中<br-fixation fixation-strength="4">心医<br-edge>院影像科,<br-bold><br-fixation fixation-strength="1">河<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">洛<br-edge>阳471000
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">新疆医科<br-fixation fixation-strength="2">大学第一<br-fixation fixation-strength="3">附属医院<br-fixation fixation-strength="4">影像中<br-edge>心核磁共振室,<br-bold><br-fixation fixation-strength="1">乌<br-fixation fixation-strength="2">鲁<br-fixation fixation-strength="3">木<br-edge>齐830054
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1006-2084
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">医<br-fixation fixation-strength="2">学<br-fixation fixation-strength="3">综<br-edge>述
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2015
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 21
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 8
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 1454-1457
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">形<br-fixation fixation-strength="4">式<br-edge>障碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">功能<br-fixation fixation-strength="2">磁共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4"><br-edge>成像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">神<br-fixation fixation-strength="2">经<br-fixation fixation-strength="3">影<br-fixation fixation-strength="4">像<br-edge>学
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">神<br-fixation fixation-strength="2">经<br-fixation fixation-strength="3">解<br-fixation fixation-strength="4">剖<br-edge>学
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">形<br-fixation fixation-strength="4">式<br-edge>障碍(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">D)<br-bold><br-fixation fixation-strength="1">的临<br-fixation fixation-strength="2">床表<br-fixation fixation-strength="3">现<br-fixation fixation-strength="4"><br-edge>多样,<br-bold><br-fixation fixation-strength="1">关于<br-fixation fixation-strength="2">本病<br-fixation fixation-strength="3">的发<br-fixation fixation-strength="4"><br-edge>病机制,<br-bold><br-fixation fixation-strength="1">生<br-fixation fixation-strength="2">物<br-fixation fixation-strength="3">化<br-edge>学、<br-bold><br-fixation fixation-strength="1">神<br-fixation fixation-strength="2">经<br-fixation fixation-strength="3">内<br-fixation fixation-strength="4">分<br-edge>泌、<br-bold><br-fixation fixation-strength="1">神经<br-fixation fixation-strength="2">免疫<br-fixation fixation-strength="3">学等<br-fixation fixation-strength="4">有不<br-edge>同的学说,<br-bold><br-fixation fixation-strength="1">但其确切<br-fixation fixation-strength="2">病因及发<br-fixation fixation-strength="3">病机制目<br-fixation fixation-strength="4">前<br-edge>未完全阐明。<br-bold><br-fixation fixation-strength="1">各领域对<br-fixation fixation-strength="2">SD发病<br-fixation fixation-strength="3">机制的研<br-fixation fixation-strength="4">究<br-edge>进程较为缓慢,<br-bold><br-fixation fixation-strength="1">且各种学说<br-fixation fixation-strength="2">所阐述的机<br-fixation fixation-strength="3">制也不完全<br-fixation fixation-strength="4">相同<br-edge>或存在矛盾之处。<br-bold><br-fixation fixation-strength="1">近<br-fixation fixation-strength="2">年<br-fixation fixation-strength="3">来,<br-bold><br-fixation fixation-strength="1">脑功能性成<br-fixation fixation-strength="2">像的发展为<br-fixation fixation-strength="3">直观探讨S<br-fixation fixation-strength="4">D的发<br-edge>病机制提供了可能,<br-bold><br-fixation fixation-strength="1">该文就神<br-fixation fixation-strength="2">经影像学<br-fixation fixation-strength="3">在SD的<br-fixation fixation-strength="4">研究<br-edge>进展予以综述,<br-bold><br-fixation fixation-strength="1">以期为S<br-fixation fixation-strength="2">D的病因<br-fixation fixation-strength="3">学研究及<br-fixation fixation-strength="4">临床<br-edge>分型提供帮助。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=664740617
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 2



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">躯体症状<br-fixation fixation-strength="2">障碍与慢<br-fixation fixation-strength="3">性失眠障<br-fixation fixation-strength="4">碍的关<br-edge>系及研究进展
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">罗<br-fixation fixation-strength="2">元<br-fixation fixation-strength="3">博
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">朱<br-fixation fixation-strength="2">玫<br-fixation fixation-strength="3">娟
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">柴<br-fixation fixation-strength="2">小<br-fixation fixation-strength="3">军
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">罗<br-fixation fixation-strength="2">杰
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">上海交<br-fixation fixation-strength="2">通大学<br-fixation fixation-strength="3">医学院<br-fixation fixation-strength="4">附属<br-edge>仁济医院,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海200127
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">上海<br-fixation fixation-strength="2">国际<br-fixation fixation-strength="3">医学<br-fixation fixation-strength="4">中心<br-edge>睡眠中心,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海201318
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">上海太<br-fixation fixation-strength="2">平康复<br-fixation fixation-strength="3">医院睡<br-fixation fixation-strength="4">眠<br-edge>康复中心,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海201315
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 2095-7130
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">世界<br-fixation fixation-strength="2">睡眠<br-fixation fixation-strength="3">医学<br-fixation fixation-strength="4"><br-edge>杂志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2022
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 9
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 5
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 983-987
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">症<br-fixation fixation-strength="4">状<br-edge>障碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">慢<br-fixation fixation-strength="2">性<br-fixation fixation-strength="3">失<br-fixation fixation-strength="4">眠<br-edge>障碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">文<br-fixation fixation-strength="2">献<br-fixation fixation-strength="3">综<br-edge>述
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">本<br-fixation fixation-strength="2">文<br-fixation fixation-strength="3">主<br-fixation fixation-strength="4">要<br-edge>围绕2015<br-bold><br-fixation fixation-strength="1">至2020<br-bold><br-fixation fixation-strength="1">年有<br-fixation fixation-strength="2">关躯<br-fixation fixation-strength="3">体症<br-fixation fixation-strength="4"><br-edge>状障碍(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">D)<br-bold><br-fixation fixation-strength="1">与慢<br-fixation fixation-strength="2">性失<br-fixation fixation-strength="3">眠<br-fixation fixation-strength="4"><br-edge>障碍(<br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">I<br-fixation fixation-strength="3">D)<br-bold><br-fixation fixation-strength="1">的相<br-fixation fixation-strength="2">关文<br-fixation fixation-strength="3">献开<br-fixation fixation-strength="4"><br-edge>展综述,<br-bold><br-fixation fixation-strength="1">从临<br-fixation fixation-strength="2">床表<br-fixation fixation-strength="3">现和<br-fixation fixation-strength="4">病<br-edge>理生理2<br-bold><br-fixation fixation-strength="1">个方面讨论<br-fixation fixation-strength="2">了躯体症状<br-fixation fixation-strength="3">障碍和慢性<br-fixation fixation-strength="4">失眠<br-edge>障碍之间的关系,<br-bold><br-fixation fixation-strength="1">认<br-fixation fixation-strength="2">为<br-fixation fixation-strength="3">多<br-fixation fixation-strength="4">巴<br-edge>胺、<br-bold><br-fixation fixation-strength="1">褪<br-fixation fixation-strength="2">黑<br-fixation fixation-strength="3">素、<br-bold><br-fixation fixation-strength="1">阿片受体以<br-fixation fixation-strength="2">及情绪变化<br-fixation fixation-strength="3">对躯体症状<br-fixation fixation-strength="4">障碍和慢性<br-edge>失眠障碍有一定影响,<br-bold><br-fixation fixation-strength="1">提出了<br-fixation fixation-strength="2">未来S<br-fixation fixation-strength="3">SD与<br-fixation fixation-strength="4">CID<br-edge>的研究方向。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7107573316
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 1



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">躯体形式疼<br-fixation fixation-strength="2">痛障碍基于<br-fixation fixation-strength="3">ReHo的<br-fixation fixation-strength="4">脑静息态功<br-edge>能磁共振成像研究
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">毛<br-fixation fixation-strength="2">椿<br-fixation fixation-strength="3">平
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">杨<br-fixation fixation-strength="2">涛
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">罗<br-fixation fixation-strength="2">伟
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">汪<br-fixation fixation-strength="2">卫<br-fixation fixation-strength="3">兵
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">黄<br-fixation fixation-strength="2">劲<br-fixation fixation-strength="3">柏
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">湖北<br-fixation fixation-strength="2">省长<br-fixation fixation-strength="3">江大<br-fixation fixation-strength="4">学临<br-edge>床医学院,<br-bold><br-fixation fixation-strength="1">长江大<br-fixation fixation-strength="2">学附属<br-fixation fixation-strength="3">第一医<br-fixation fixation-strength="4"><br-edge>院放射科,<br-bold><br-fixation fixation-strength="1">湖<br-fixation fixation-strength="2">北<br-fixation fixation-strength="3">荆<br-edge>州434000
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1001-9324
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">临床<br-fixation fixation-strength="2">放射<br-fixation fixation-strength="3">学<br-fixation fixation-strength="4"><br-edge>杂志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2016
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 35
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 7
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 1008-1012
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">躯体<br-fixation fixation-strength="2">形式<br-fixation fixation-strength="3">疼痛<br-fixation fixation-strength="4"><br-edge>障碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">局<br-fixation fixation-strength="2">部<br-fixation fixation-strength="3">一<br-fixation fixation-strength="4">致<br-edge>性
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">静息<br-fixation fixation-strength="2">态功<br-fixation fixation-strength="3">能磁<br-fixation fixation-strength="4">共<br-edge>振成像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的<br-fixation fixation-strength="2">采用<br-fixation fixation-strength="3">基于<br-fixation fixation-strength="4">局部<br-edge>一致性(<br-bold><br-fixation fixation-strength="1">R<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">H<br-edge>o)<br-bold><br-fixation fixation-strength="1">的功<br-fixation fixation-strength="2">能磁<br-fixation fixation-strength="3">共振<br-fixation fixation-strength="4"><br-edge>成像(<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-edge>I)<br-bold><br-fixation fixation-strength="1">分析法<br-fixation fixation-strength="2">探讨躯<br-fixation fixation-strength="3">体形式<br-fixation fixation-strength="4"><br-edge>疼痛障碍(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">P<br-fixation fixation-strength="3">D)<br-bold><br-fixation fixation-strength="1">患者静<br-fixation fixation-strength="2">息状态<br-fixation fixation-strength="3">下的脑<br-fixation fixation-strength="4">功能<br-edge>活动特点。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法 15<br-bold><br-fixation fixation-strength="1">例S<br-fixation fixation-strength="2">PD<br-fixation fixation-strength="3">患者<br-fixation fixation-strength="4">为<br-edge>病例组,15<br-bold><br-fixation fixation-strength="1">名健<br-fixation fixation-strength="2">康志<br-fixation fixation-strength="3">愿者<br-fixation fixation-strength="4">为正<br-edge>常对照组(<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">C<br-fixation fixation-strength="3">组),<br-bold><br-fixation fixation-strength="1">通过<br-fixation fixation-strength="2">疼痛<br-fixation fixation-strength="3">数字<br-fixation fixation-strength="4">评<br-edge>价量表(<br-bold><br-fixation fixation-strength="1">N<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">S)<br-bold><br-fixation fixation-strength="1">评分<br-fixation fixation-strength="2">后行<br-fixation fixation-strength="3">静息<br-fixation fixation-strength="4">态f<br-edge>MRI(<br-bold><br-fixation fixation-strength="1">r<br-fixation fixation-strength="2">s-<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-edge>I)<br-bold><br-fixation fixation-strength="1">数<br-fixation fixation-strength="2">据<br-fixation fixation-strength="3">采<br-edge>集。<br-bold><br-fixation fixation-strength="1">对所<br-fixation fixation-strength="2">有图<br-fixation fixation-strength="3">像预<br-fixation fixation-strength="4"><br-edge>处理,<br-bold><br-fixation fixation-strength="1">计算两<br-fixation fixation-strength="2">组受试<br-fixation fixation-strength="3">者全脑<br-fixation fixation-strength="4">R<br-edge>eHo值,<br-bold><br-fixation fixation-strength="1">经统计学处<br-fixation fixation-strength="2">理后获得S<br-fixation fixation-strength="3">PD患者R<br-fixation fixation-strength="4">eHo<br-edge>值有意义的脑区；<br-bold><br-fixation fixation-strength="1">将SPD患者<br-fixation fixation-strength="2">ReHo异常<br-fixation fixation-strength="3">脑区的ReH<br-fixation fixation-strength="4">o值与N<br-edge>RS得分做相关性分析。<br-bold><br-fixation fixation-strength="1">结果<br-fixation fixation-strength="2">与正<br-fixation fixation-strength="3">常对<br-fixation fixation-strength="4">照<br-edge>组相比,<br-bold><br-fixation fixation-strength="1">SPD患者<br-fixation fixation-strength="2">在静息状态<br-fixation fixation-strength="3">下ReHo<br-fixation fixation-strength="4">值升高的脑<br-edge>区为右侧小脑后叶,<br-bold><br-fixation fixation-strength="1">ReH<br-fixation fixation-strength="2">o值减<br-fixation fixation-strength="3">低的脑<br-fixation fixation-strength="4">区为<br-edge>左侧颞上回、<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">中<br-fixation fixation-strength="4">央<br-edge>前回、<br-bold><br-fixation fixation-strength="1">右<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">小<br-fixation fixation-strength="4">脑<br-edge>前叶、<br-bold><br-fixation fixation-strength="1">右侧<br-fixation fixation-strength="2">小脑<br-fixation fixation-strength="3">山顶<br-fixation fixation-strength="4">及小<br-edge>脑山坡；<br-bold><br-fixation fixation-strength="1">相关性分析显<br-fixation fixation-strength="2">示上述脑区域<br-fixation fixation-strength="3">ReHo值的<br-fixation fixation-strength="4">改变与NR<br-edge>S得分均无显著相关性(<br-bold><br-fixation fixation-strength="1">P>0.05)。<br-bold><br-fixation fixation-strength="1">结<br-fixation fixation-strength="2">论 <br-bold><br-fixation fixation-strength="1">SPD患<br-fixation fixation-strength="2">者右侧小<br-fixation fixation-strength="3">脑后叶的<br-fixation fixation-strength="4">R<br-edge>eHo值升高,<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">颞<br-fixation fixation-strength="4">上<br-edge>回、<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">中<br-fixation fixation-strength="4">央<br-edge>前回、<br-bold><br-fixation fixation-strength="1">右<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">小<br-fixation fixation-strength="4">脑<br-edge>前叶、<br-bold><br-fixation fixation-strength="1">右侧小脑<br-fixation fixation-strength="2">山顶及小<br-fixation fixation-strength="3">脑山坡的<br-fixation fixation-strength="4">R<br-edge>eHo值减低,<br-bold><br-fixation fixation-strength="1">提示这些<br-fixation fixation-strength="2">脑区可能<br-fixation fixation-strength="3">与SPD<br-fixation fixation-strength="4">的潜在病<br-edge>理生理机制有关,<br-bold><br-fixation fixation-strength="1">SPD患者异<br-fixation fixation-strength="2">常激活脑区R<br-fixation fixation-strength="3">eHo值的改<br-fixation fixation-strength="4">变与疼痛<br-edge>程度均无显著相关性。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=669513188
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 0
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">湖北省<br-fixation fixation-strength="2">教育厅<br-fixation fixation-strength="3">科研项<br-fixation fixation-strength="4">目<br-edge>基金资助(<br-bold><br-fixation fixation-strength="1">编<br-fixation fixation-strength="2">号:<br-bold><br-fixation fixation-strength="1">B2015441)



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">基于静系统<br-fixation fixation-strength="2">功能磁共振<br-fixation fixation-strength="3">的躯体化障<br-fixation fixation-strength="4">碍默认网络<br-edge>的自发神经活动研究
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">万<br-fixation fixation-strength="2">红<br-fixation fixation-strength="3">艳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">鲁<br-fixation fixation-strength="2">际
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">金<br-fixation fixation-strength="2">晶
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">雷<br-fixation fixation-strength="2">莉
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">湖北<br-fixation fixation-strength="2">省枝<br-fixation fixation-strength="3">江市<br-fixation fixation-strength="4">人<br-edge>民医院,<br-bold><br-fixation fixation-strength="1">枝<br-fixation fixation-strength="2">江443200
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">三峡大学<br-fixation fixation-strength="2">第一临床<br-fixation fixation-strength="3">医学院宜<br-fixation fixation-strength="4">昌市<br-edge>中心人民医院
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">三峡大<br-fixation fixation-strength="2">学中医<br-fixation fixation-strength="3">临床医<br-fixation fixation-strength="4">学院宜<br-edge>昌市中医院
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">三峡<br-fixation fixation-strength="2">大学<br-fixation fixation-strength="3">第二<br-fixation fixation-strength="4">人<br-edge>民医院
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1673-2952
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">国际<br-fixation fixation-strength="2">精神<br-fixation fixation-strength="3">病学<br-fixation fixation-strength="4"><br-edge>杂志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2017
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 44
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 4
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 616-618+634
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">静息<br-fixation fixation-strength="2">态功<br-fixation fixation-strength="3">能核<br-fixation fixation-strength="4"><br-edge>磁共振
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">化<br-fixation fixation-strength="4">障<br-edge>碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">自<br-fixation fixation-strength="2">发<br-fixation fixation-strength="3">神<br-fixation fixation-strength="4">经<br-edge>活动
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">严<br-fixation fixation-strength="2">重<br-fixation fixation-strength="3">程<br-edge>度
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的探<br-fixation fixation-strength="2">讨运用<br-fixation fixation-strength="3">静系统<br-fixation fixation-strength="4">功<br-edge>能磁共振(<br-bold><br-fixation fixation-strength="1">r<br-fixation fixation-strength="2">s-<br-bold><br-fixation fixation-strength="1">f <br-bold><br-fixation fixation-strength="1">M<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">I)<br-bold><br-fixation fixation-strength="1">方法研究<br-fixation fixation-strength="2">躯体化障<br-fixation fixation-strength="3">碍默认网<br-fixation fixation-strength="4">络的自发<br-edge>神经活动的机制。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法<br-fixation fixation-strength="3">选<br-edge>取2014<br-bold><br-fixation fixation-strength="1">年6<br-bold><br-fixation fixation-strength="1">月<br-fixation fixation-strength="2">至2016<br-bold><br-fixation fixation-strength="1">年8<br-bold><br-fixation fixation-strength="1">月于我<br-fixation fixation-strength="2">院就诊<br-fixation fixation-strength="3">的躯体<br-fixation fixation-strength="4">化障<br-edge>碍患者共80<br-bold><br-fixation fixation-strength="1">例(<br-bold><br-fixation fixation-strength="1">观<br-fixation fixation-strength="2">察<br-fixation fixation-strength="3">组),<br-bold><br-fixation fixation-strength="1">取80<br-bold><br-fixation fixation-strength="1">例<br-fixation fixation-strength="2">名<br-fixation fixation-strength="3">年<br-edge>龄、<br-bold><br-fixation fixation-strength="1">性<br-fixation fixation-strength="2">别、<br-bold><br-fixation fixation-strength="1">教育程度<br-fixation fixation-strength="2">均匹配的<br-fixation fixation-strength="3">健康体检<br-fixation fixation-strength="4">者<br-edge>作为对照组。<br-bold><br-fixation fixation-strength="1">所有患<br-fixation fixation-strength="2">者均使<br-fixation fixation-strength="3">用HA<br-fixation fixation-strength="4"><br-edge>MD量表、<br-bold><br-fixation fixation-strength="1">和<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">C<br-edge>L-90<br-bold><br-fixation fixation-strength="1">量表的<br-fixation fixation-strength="2">躯体化<br-fixation fixation-strength="3">障碍因<br-fixation fixation-strength="4">子分<br-edge>量表评估,<br-bold><br-fixation fixation-strength="1">并<br-fixation fixation-strength="2">进<br-fixation fixation-strength="3">行<br-fixation fixation-strength="4">r<br-edge>s-<br-bold><br-fixation fixation-strength="1">f <br-bold><br-fixation fixation-strength="1">MR<br-fixation fixation-strength="2">I扫<br-fixation fixation-strength="3">描<br-fixation fixation-strength="4"><br-edge>分析。<br-bold><br-fixation fixation-strength="1">结果其<br-fixation fixation-strength="2">中观察<br-fixation fixation-strength="3">组患者<br-fixation fixation-strength="4"><br-edge>HAMD、<br-bold><br-fixation fixation-strength="1">HAMA<br-fixation fixation-strength="2">和躯体化<br-fixation fixation-strength="3">障碍因子<br-fixation fixation-strength="4">评分显<br-edge>著高于对照组(<br-bold><br-fixation fixation-strength="1">P52 <br-bold><br-fixation fixation-strength="1">v<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">x<br-fixation fixation-strength="4">e<br-edge>l),<br-bold><br-fixation fixation-strength="1">与<br-fixation fixation-strength="2">年<br-fixation fixation-strength="3">龄、<br-bold><br-fixation fixation-strength="1">教<br-fixation fixation-strength="2">育<br-fixation fixation-strength="3">年<br-edge>限、<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">程、<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">M<br-edge>D、<br-bold><br-fixation fixation-strength="1">HA<br-fixation fixation-strength="2">MA<br-fixation fixation-strength="3">评分<br-fixation fixation-strength="4">无显<br-edge>著相关性。<br-bold><br-fixation fixation-strength="1">结论躯体<br-fixation fixation-strength="2">化障碍患<br-fixation fixation-strength="3">者DMN<br-fixation fixation-strength="4">神经活<br-edge>动存在分离模式,<br-bold><br-fixation fixation-strength="1">M<br-fixation fixation-strength="2">P<br-fixation fixation-strength="3">F<br-fixation fixation-strength="4">C<br-edge>的f <br-bold><br-fixation fixation-strength="1">ALFF<br-fixation fixation-strength="2">值可作为<br-fixation fixation-strength="3">判断躯体<br-fixation fixation-strength="4">化症状<br-edge>严重程度的指标。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=673034548
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 3



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">基于全脑低频振<br-fixation fixation-strength="2">幅的功能磁共振<br-fixation fixation-strength="3">成像青少年抑郁<br-fixation fixation-strength="4">症患者认知<br-edge>功能损害影响因素及机制
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">张<br-fixation fixation-strength="2">午<br-fixation fixation-strength="3">阳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">李<br-fixation fixation-strength="2">淑<br-fixation fixation-strength="3">英
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">王<br-fixation fixation-strength="2">源<br-fixation fixation-strength="3">莉
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">吕<br-fixation fixation-strength="2">培<br-fixation fixation-strength="3">培
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">张<br-fixation fixation-strength="2">瑶
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">潘<br-fixation fixation-strength="2">红<br-fixation fixation-strength="3">庆
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">杨<br-fixation fixation-strength="2">灿
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">郑州大<br-fixation fixation-strength="2">学第一<br-fixation fixation-strength="3">附属医<br-fixation fixation-strength="4">院精<br-edge>神医学科,<br-bold><br-fixation fixation-strength="1">河<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">郑<br-edge>州450052
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1004-437<br-bold><br-fixation fixation-strength="1">X
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">河<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">医<br-fixation fixation-strength="4">学<br-edge>研究
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2021
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 30
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 1
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 24-28
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">青<br-fixation fixation-strength="2">少<br-fixation fixation-strength="3">年
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">抑<br-fixation fixation-strength="2">郁<br-fixation fixation-strength="3">症
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">功能<br-fixation fixation-strength="2">磁共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4"><br-edge>成像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">低<br-fixation fixation-strength="2">频<br-fixation fixation-strength="3">振<br-edge>幅
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">认<br-fixation fixation-strength="2">知<br-fixation fixation-strength="3">功<br-edge>能
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的研究青<br-fixation fixation-strength="2">少年抑郁症<br-fixation fixation-strength="3">患者认知功<br-fixation fixation-strength="4">能损害的影<br-edge>响因素及影像学机制。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法<br-fixation fixation-strength="3">纳<br-edge>入2014—2016<br-bold><br-fixation fixation-strength="1">年于郑州<br-fixation fixation-strength="2">大学第一<br-fixation fixation-strength="3">附属医院<br-fixation fixation-strength="4">精神<br-edge>医学科住院的78<br-bold><br-fixation fixation-strength="1">例首发<br-fixation fixation-strength="2">未服药<br-fixation fixation-strength="3">青少年<br-fixation fixation-strength="4">抑<br-edge>郁症患者,<br-bold><br-fixation fixation-strength="1">收集<br-fixation fixation-strength="2">一般<br-fixation fixation-strength="3">人口<br-fixation fixation-strength="4"><br-edge>学资料,<br-bold><br-fixation fixation-strength="1">以17<br-bold><br-fixation fixation-strength="1">项汉<br-fixation fixation-strength="2">密尔<br-fixation fixation-strength="3">顿抑<br-fixation fixation-strength="4"><br-edge>郁量表(<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">M<br-edge>D-17)<br-bold><br-fixation fixation-strength="1">因子<br-fixation fixation-strength="2">分评<br-fixation fixation-strength="3">估抑<br-fixation fixation-strength="4"><br-edge>郁症状,<br-bold><br-fixation fixation-strength="1">采用<br-fixation fixation-strength="2">威斯<br-fixation fixation-strength="3">康星<br-fixation fixation-strength="4">卡片<br-edge>分类测验(<br-bold><br-fixation fixation-strength="1">W<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">C<br-edge>T)<br-bold><br-fixation fixation-strength="1">及<br-fixation fixation-strength="2">连<br-fixation fixation-strength="3">线<br-fixation fixation-strength="4">测<br-edge>验(<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">T)<br-bold><br-fixation fixation-strength="1">评<br-fixation fixation-strength="2">估<br-fixation fixation-strength="3">认<br-fixation fixation-strength="4">知<br-edge>功能,<br-bold><br-fixation fixation-strength="1">并对受<br-fixation fixation-strength="2">试者进<br-fixation fixation-strength="3">行功能<br-fixation fixation-strength="4">磁<br-edge>共振成像(<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-edge>I)<br-bold><br-fixation fixation-strength="1">扫<br-fixation fixation-strength="2">描。<br-bold><br-fixation fixation-strength="1">结<br-fixation fixation-strength="2">果<br-fixation fixation-strength="3">焦<br-edge>虑/<br-bold><br-fixation fixation-strength="1">躯体<br-fixation fixation-strength="2">化与<br-fixation fixation-strength="3">完成<br-fixation fixation-strength="4"><br-edge>分类数、<br-bold><br-fixation fixation-strength="1">正确<br-fixation fixation-strength="2">应答<br-fixation fixation-strength="3">数呈<br-fixation fixation-strength="4"><br-edge>负相关(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">迟缓与<br-fixation fixation-strength="2">非持续<br-fixation fixation-strength="3">错误数<br-fixation fixation-strength="4"><br-edge>呈正相关(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">睡眠<br-fixation fixation-strength="2">障碍<br-fixation fixation-strength="3">与完<br-fixation fixation-strength="4">成<br-edge>分类数、<br-bold><br-fixation fixation-strength="1">正<br-fixation fixation-strength="2">确<br-fixation fixation-strength="3">应<br-fixation fixation-strength="4">答<br-edge>数、<br-bold><br-fixation fixation-strength="1">持<br-fixation fixation-strength="2">续<br-fixation fixation-strength="3">应<br-fixation fixation-strength="4">答<br-edge>数、<br-bold><br-fixation fixation-strength="1">概念<br-fixation fixation-strength="2">水平<br-fixation fixation-strength="3">百分<br-fixation fixation-strength="4">数呈<br-edge>负相关,<br-bold><br-fixation fixation-strength="1">与<br-fixation fixation-strength="2">总<br-fixation fixation-strength="3">应<br-fixation fixation-strength="4">答<br-edge>数、<br-bold><br-fixation fixation-strength="1">错<br-fixation fixation-strength="2">误<br-fixation fixation-strength="3">应<br-fixation fixation-strength="4">答<br-edge>数、<br-bold><br-fixation fixation-strength="1">持<br-fixation fixation-strength="2">续<br-fixation fixation-strength="3">错<br-fixation fixation-strength="4">误<br-edge>数、<br-bold><br-fixation fixation-strength="1">非持<br-fixation fixation-strength="2">续错<br-fixation fixation-strength="3">误数<br-fixation fixation-strength="4">呈<br-edge>正相关(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">连<br-fixation fixation-strength="2">线<br-fixation fixation-strength="3">测<br-fixation fixation-strength="4">验<br-edge>A(<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">T-<br-bold><br-fixation fixation-strength="1">A)<br-bold><br-fixation fixation-strength="1">时间<br-fixation fixation-strength="2">与睡<br-fixation fixation-strength="3">眠障<br-fixation fixation-strength="4">碍呈<br-edge>正相关(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">焦<br-fixation fixation-strength="2">虑/<br-bold><br-fixation fixation-strength="1">躯体<br-fixation fixation-strength="2">化与<br-fixation fixation-strength="3">右梭<br-fixation fixation-strength="4"><br-edge>状回、<br-bold><br-fixation fixation-strength="1">右中央<br-fixation fixation-strength="2">后回标<br-fixation fixation-strength="3">准化全<br-fixation fixation-strength="4">脑平<br-edge>均低频振幅(<br-bold><br-fixation fixation-strength="1">m<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">L<br-fixation fixation-strength="4">F<br-edge>F)<br-bold><br-fixation fixation-strength="1">呈<br-fixation fixation-strength="2">正<br-fixation fixation-strength="3">相<br-edge>关(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">迟缓<br-fixation fixation-strength="2">与左<br-fixation fixation-strength="3">颞中<br-fixation fixation-strength="4">回呈<br-edge>正相关,<br-bold><br-fixation fixation-strength="1">与左<br-fixation fixation-strength="2">颞下<br-fixation fixation-strength="3">回呈<br-fixation fixation-strength="4"><br-edge>负相关(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">睡眠障<br-fixation fixation-strength="2">碍与右<br-fixation fixation-strength="3">顶上回<br-fixation fixation-strength="4"><br-edge>呈正相关,<br-bold><br-fixation fixation-strength="1">与<br-fixation fixation-strength="2">左<br-fixation fixation-strength="3">丘<br-edge>脑、<br-bold><br-fixation fixation-strength="1">右<br-fixation fixation-strength="2">丘<br-fixation fixation-strength="3">脑、<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">扣<br-fixation fixation-strength="3">带<br-edge>回、<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">海<br-fixation fixation-strength="3">马<br-edge>体、<br-bold><br-fixation fixation-strength="1">右海<br-fixation fixation-strength="2">马旁<br-fixation fixation-strength="3">回呈<br-fixation fixation-strength="4"><br-edge>负相关(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">其<br-fixation fixation-strength="2">中,<br-bold><br-fixation fixation-strength="1">右<br-fixation fixation-strength="2">丘<br-fixation fixation-strength="3">脑、<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">扣<br-fixation fixation-strength="3">带<br-edge>回、<br-bold><br-fixation fixation-strength="1">左海马体<br-fixation fixation-strength="2">及右海马<br-fixation fixation-strength="3">旁回与认<br-fixation fixation-strength="4">知<br-edge>功能损害有关(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">结论青少年<br-fixation fixation-strength="2">抑郁症患者<br-fixation fixation-strength="3">认知功能损<br-fixation fixation-strength="4">害与睡<br-edge>眠障碍密切相关,<br-bold><br-fixation fixation-strength="1">可<br-fixation fixation-strength="2">能<br-fixation fixation-strength="3">与<br-fixation fixation-strength="4">右<br-edge>丘脑、<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">扣<br-fixation fixation-strength="3">带<br-edge>回、<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">海<br-fixation fixation-strength="3">马<br-edge>体、<br-bold><br-fixation fixation-strength="1">右海马<br-fixation fixation-strength="2">旁回等<br-fixation fixation-strength="3">脑区自<br-fixation fixation-strength="4">发活<br-edge>动下降有关。<br-bold><br-fixation fixation-strength="1">焦<br-fixation fixation-strength="2">虑/<br-bold><br-fixation fixation-strength="1">躯体化与迟<br-fixation fixation-strength="2">缓症状也可<br-fixation fixation-strength="3">能是认知功<br-fixation fixation-strength="4">能损害<br-edge>的潜在危险因素。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7103749500
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 8
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">河南<br-fixation fixation-strength="2">省卫<br-fixation fixation-strength="3">健委<br-fixation fixation-strength="4">省部<br-edge>共建项目(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">B<br-fixation fixation-strength="3">G<br-edge>J2018033)；<br-bold><br-fixation fixation-strength="1">河南省<br-fixation fixation-strength="2">科技厅<br-fixation fixation-strength="3">重点攻<br-fixation fixation-strength="4">关<br-edge>计划项目(152102310046)。



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">躯体形式<br-fixation fixation-strength="2">障碍患者<br-fixation fixation-strength="3">脑葡萄糖<br-fixation fixation-strength="4">代谢<br-edge>功能网络研究
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">潘<br-fixation fixation-strength="2">智<br-fixation fixation-strength="3">伟
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">肖<br-fixation fixation-strength="2">见<br-fixation fixation-strength="3">飞
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">黄<br-fixation fixation-strength="2">琪
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">姜<br-fixation fixation-strength="2">东<br-fixation fixation-strength="3">朗
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">任<br-fixation fixation-strength="2">树<br-fixation fixation-strength="3">华
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">管<br-fixation fixation-strength="2">一<br-fixation fixation-strength="3">晖
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">谢<br-fixation fixation-strength="2">芳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">孙<br-fixation fixation-strength="2">达<br-fixation fixation-strength="3">亮
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">华<br-fixation fixation-strength="2">逢<br-fixation fixation-strength="3">春
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">复旦大<br-fixation fixation-strength="2">学附属<br-fixation fixation-strength="3">华山医<br-fixation fixation-strength="4">院P<br-edge>ET中心,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海200235
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">天津<br-fixation fixation-strength="2">市安<br-fixation fixation-strength="3">定医<br-fixation fixation-strength="4">院<br-edge>精神科,300222
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 2095-2848
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">中华<br-fixation fixation-strength="2">核医<br-fixation fixation-strength="3">学与<br-fixation fixation-strength="4">分子<br-edge>影像杂志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2020
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 40
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 1
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 6-10
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">型<br-fixation fixation-strength="4">障<br-edge>碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">代谢<br-fixation fixation-strength="2">网络<br-fixation fixation-strength="3">和<br-fixation fixation-strength="4"><br-edge>途径
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">脑
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">正电<br-fixation fixation-strength="2">子发<br-fixation fixation-strength="3">射断<br-fixation fixation-strength="4">层<br-edge>显像术
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">脱<br-fixation fixation-strength="2">氧<br-fixation fixation-strength="3">葡<br-fixation fixation-strength="4">萄<br-edge>糖
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的<br-fixation fixation-strength="2">探讨<br-fixation fixation-strength="3">躯体<br-fixation fixation-strength="4">形<br-edge>式障碍(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">F<br-fixation fixation-strength="3">D)<br-bold><br-fixation fixation-strength="1">患者大<br-fixation fixation-strength="2">脑葡萄<br-fixation fixation-strength="3">糖代谢<br-fixation fixation-strength="4">网络<br-edge>的拓扑变化。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法<br-fixation fixation-strength="3">用2011<br-bold><br-fixation fixation-strength="1">年10<br-bold><br-fixation fixation-strength="1">月<br-fixation fixation-strength="2">至2012<br-bold><br-fixation fixation-strength="1">年12<br-bold><br-fixation fixation-strength="1">月期间<br-fixation fixation-strength="2">复旦大<br-fixation fixation-strength="3">学附属<br-fixation fixation-strength="4">华<br-edge>山医院的18<br-bold><br-fixation fixation-strength="1">例<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">F<br-fixation fixation-strength="4">D<br-edge>患者[<br-bold><br-fixation fixation-strength="1">男10<br-bold><br-fixation fixation-strength="1">例、<br-bold><br-fixation fixation-strength="1">女8<br-bold><br-fixation fixation-strength="1">例,<br-bold><br-fixation fixation-strength="1">年<br-fixation fixation-strength="2">龄(39.5±12.0)<br-bold><br-fixation fixation-strength="1">岁,<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">程(3.67±3.20)<br-bold><br-fixation fixation-strength="1">年；<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">F<br-fixation fixation-strength="3">D<br-edge>组]、21<br-bold><br-fixation fixation-strength="1">名健<br-fixation fixation-strength="2">康体<br-fixation fixation-strength="3">格检<br-fixation fixation-strength="4"><br-edge>查者[<br-bold><br-fixation fixation-strength="1">男13<br-bold><br-fixation fixation-strength="1">名、<br-bold><br-fixation fixation-strength="1">女8<br-bold><br-fixation fixation-strength="1">名,<br-bold><br-fixation fixation-strength="1">年<br-fixation fixation-strength="2">龄(43.9±8.4)<br-bold><br-fixation fixation-strength="1">岁；<br-bold><br-fixation fixation-strength="1">对<br-fixation fixation-strength="2">照<br-fixation fixation-strength="3">组]<br-bold><br-fixation fixation-strength="1">的18<br-bold><br-fixation fixation-strength="1">F-<br-bold><br-fixation fixation-strength="1">脱<br-fixation fixation-strength="2">氧<br-fixation fixation-strength="3">葡<br-fixation fixation-strength="4">萄<br-edge>糖(<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">G)<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">E<br-fixation fixation-strength="3">T<br-fixation fixation-strength="4">图<br-edge>像,<br-bold><br-fixation fixation-strength="1">建立<br-fixation fixation-strength="2">静息<br-fixation fixation-strength="3">状<br-fixation fixation-strength="4"><br-edge>态下2<br-bold><br-fixation fixation-strength="1">组的<br-fixation fixation-strength="2">大脑<br-fixation fixation-strength="3">葡萄<br-fixation fixation-strength="4">糖代<br-edge>谢网络。<br-bold><br-fixation fixation-strength="1">使用图<br-fixation fixation-strength="2">论的方<br-fixation fixation-strength="3">法计算<br-fixation fixation-strength="4">脑网络<br-edge>的全局参数(<br-bold><br-fixation fixation-strength="1">标准<br-fixation fixation-strength="2">化聚<br-fixation fixation-strength="3">类<br-fixation fixation-strength="4"><br-edge>系数、<br-bold><br-fixation fixation-strength="1">标准<br-fixation fixation-strength="2">化最<br-fixation fixation-strength="3">短路<br-fixation fixation-strength="4"><br-edge>径长度、<br-bold><br-fixation fixation-strength="1">小世<br-fixation fixation-strength="2">界属<br-fixation fixation-strength="3">性和<br-fixation fixation-strength="4">全<br-edge>局效率)<br-bold><br-fixation fixation-strength="1">和<br-fixation fixation-strength="2">节<br-fixation fixation-strength="3">点<br-fixation fixation-strength="4">参<br-edge>数(<br-bold><br-fixation fixation-strength="1">聚类<br-fixation fixation-strength="2">系数<br-fixation fixation-strength="3">和介<br-fixation fixation-strength="4">数<br-edge>中心度)。2<br-bold><br-fixation fixation-strength="1">组脑网<br-fixation fixation-strength="2">络参数<br-fixation fixation-strength="3">间的差<br-fixation fixation-strength="4">异<br-edge>采用重复1000<br-bold><br-fixation fixation-strength="1">次的置<br-fixation fixation-strength="2">换检验<br-fixation fixation-strength="3">进行统<br-fixation fixation-strength="4"><br-edge>计学分析。<br-bold><br-fixation fixation-strength="1">根据聚<br-fixation fixation-strength="2">类系数<br-fixation fixation-strength="3">和介数<br-fixation fixation-strength="4">中心<br-edge>度定义前20%(18/90)<br-bold><br-fixation fixation-strength="1">的节<br-fixation fixation-strength="2">点为<br-fixation fixation-strength="3">脑网<br-fixation fixation-strength="4">络<br-edge>的关键(<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">b)<br-bold><br-fixation fixation-strength="1">节<br-fixation fixation-strength="2">点,<br-bold><br-fixation fixation-strength="1">分析S<br-fixation fixation-strength="2">FD患<br-fixation fixation-strength="3">者Hu<br-fixation fixation-strength="4">b节<br-edge>点的改变。<br-bold><br-fixation fixation-strength="1">结果SFD<br-fixation fixation-strength="2">组患者的脑<br-fixation fixation-strength="3">网络和对照<br-fixation fixation-strength="4">组一样<br-edge>具有小世界属性(<br-bold><br-fixation fixation-strength="1">σ>1),<br-bold><br-fixation fixation-strength="1">但标<br-fixation fixation-strength="2">准化<br-fixation fixation-strength="3">聚类<br-fixation fixation-strength="4"><br-edge>系数、<br-bold><br-fixation fixation-strength="1">小世界<br-fixation fixation-strength="2">属性和<br-fixation fixation-strength="3">全局效<br-fixation fixation-strength="4">率有<br-edge>降低趋势,<br-bold><br-fixation fixation-strength="1">标准化<br-fixation fixation-strength="2">最短路<br-fixation fixation-strength="3">径长度<br-fixation fixation-strength="4">有<br-edge>增加趋势(<br-bold><br-fixation fixation-strength="1">P>0.05)。<br-bold><br-fixation fixation-strength="1">与<br-fixation fixation-strength="2">对<br-fixation fixation-strength="3">照<br-fixation fixation-strength="4">组<br-edge>相比,<br-bold><br-fixation fixation-strength="1">SF<br-fixation fixation-strength="2">D患<br-fixation fixation-strength="3">者左<br-fixation fixation-strength="4">侧<br-edge>苍白球、<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">杏<br-fixation fixation-strength="4">仁<br-edge>核、<br-bold><br-fixation fixation-strength="1">左侧楔前<br-fixation fixation-strength="2">叶和右侧<br-fixation fixation-strength="3">角回的介<br-fixation fixation-strength="4">数中<br-edge>心度明显升高(<br-bold><br-fixation fixation-strength="1">置<br-fixation fixation-strength="2">换<br-fixation fixation-strength="3">检<br-edge>验,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">左侧颞中<br-fixation fixation-strength="2">回和右侧<br-fixation fixation-strength="3">枕上回的<br-fixation fixation-strength="4">介数中<br-edge>心度明显降低(<br-bold><br-fixation fixation-strength="1">置<br-fixation fixation-strength="2">换<br-fixation fixation-strength="3">检<br-edge>验,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">双<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">苍<br-fixation fixation-strength="4">白<br-edge>球、<br-bold><br-fixation fixation-strength="1">双侧丘脑<br-fixation fixation-strength="2">和左侧杏<br-fixation fixation-strength="3">仁核的聚<br-fixation fixation-strength="4">类<br-edge>系数明显降低(<br-bold><br-fixation fixation-strength="1">置<br-fixation fixation-strength="2">换<br-fixation fixation-strength="3">检<br-edge>验,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">SFD<br-fixation fixation-strength="2">组发生<br-fixation fixation-strength="3">改变的<br-fixation fixation-strength="4">Hu<br-edge>b节点多数(16/24)<br-bold><br-fixation fixation-strength="1">位<br-fixation fixation-strength="2">于<br-fixation fixation-strength="3">边<br-fixation fixation-strength="4">缘<br-edge>系统。<br-bold><br-fixation fixation-strength="1">结论SFD<br-fixation fixation-strength="2">患者的葡萄<br-fixation fixation-strength="3">糖代谢脑网<br-fixation fixation-strength="4">络拓<br-edge>扑性质发生改变,<br-bold><br-fixation fixation-strength="1">小世界属性<br-fixation fixation-strength="2">和全局效率<br-fixation fixation-strength="3">呈降低的趋<br-fixation fixation-strength="4">势及H<br-edge>ub节点的改变,<br-bold><br-fixation fixation-strength="1">导致网<br-fixation fixation-strength="2">络信息<br-fixation fixation-strength="3">传递效<br-fixation fixation-strength="4">率<br-edge>有所降低,<br-bold><br-fixation fixation-strength="1">功能整<br-fixation fixation-strength="2">合和功<br-fixation fixation-strength="3">能分离<br-fixation fixation-strength="4">的平<br-edge>衡被打破,<br-bold><br-fixation fixation-strength="1">这为躯体化<br-fixation fixation-strength="2">症状的脑功<br-fixation fixation-strength="3">能异常提供<br-fixation fixation-strength="4">了有<br-edge>效的影像学证据。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7100885382
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 3



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">伴自杀<br-fixation fixation-strength="2">意念首<br-fixation fixation-strength="3">发抑郁<br-fixation fixation-strength="4">症<br-edge>患者小脑-<br-bold><br-fixation fixation-strength="1">大脑功<br-fixation fixation-strength="2">能连接<br-fixation fixation-strength="3">的fM<br-fixation fixation-strength="4"><br-edge>RI研究
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">姜<br-fixation fixation-strength="2">雨
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">陈<br-fixation fixation-strength="2">苑
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">韩<br-fixation fixation-strength="2">少<br-fixation fixation-strength="3">强
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">郑<br-fixation fixation-strength="2">瑞<br-fixation fixation-strength="3">平
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">周<br-fixation fixation-strength="2">冰<br-fixation fixation-strength="3">倩
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">李<br-fixation fixation-strength="2">淑<br-fixation fixation-strength="3">英
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">程<br-fixation fixation-strength="2">敬<br-fixation fixation-strength="3">亮
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">郑州大<br-fixation fixation-strength="2">学第一<br-fixation fixation-strength="3">附属医<br-fixation fixation-strength="4">院<br-edge>磁共振科,<br-bold><br-fixation fixation-strength="1">河<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">郑<br-edge>州450052
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">郑州大<br-fixation fixation-strength="2">学第一<br-fixation fixation-strength="3">附属医<br-fixation fixation-strength="4"><br-edge>院精神科,<br-bold><br-fixation fixation-strength="1">河<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">郑<br-edge>州450052
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1000-0313
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">放<br-fixation fixation-strength="2">射<br-fixation fixation-strength="3">学<br-fixation fixation-strength="4">实<br-edge>践
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2024
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 39
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 4
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 429-435
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">抑<br-fixation fixation-strength="2">郁<br-fixation fixation-strength="3">症
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">自<br-fixation fixation-strength="2">杀<br-fixation fixation-strength="3">意<br-edge>念
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">功<br-fixation fixation-strength="2">能<br-fixation fixation-strength="3">连<br-edge>接
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">小<br-fixation fixation-strength="2">脑
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">静<br-fixation fixation-strength="2">息<br-fixation fixation-strength="3">态
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">功能<br-fixation fixation-strength="2">磁共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4"><br-edge>成像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目<br-fixation fixation-strength="2">的:<br-bold><br-fixation fixation-strength="1">基于静息态<br-fixation fixation-strength="2">fMRI探<br-fixation fixation-strength="3">讨伴自杀意<br-fixation fixation-strength="4">念的首<br-edge>发抑郁症患者小脑-<br-bold><br-fixation fixation-strength="1">大<br-fixation fixation-strength="2">脑<br-fixation fixation-strength="3">功<br-fixation fixation-strength="4">能<br-edge>连接(<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">C)<br-bold><br-fixation fixation-strength="1">的<br-fixation fixation-strength="2">改<br-fixation fixation-strength="3">变。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法:<br-bold><br-fixation fixation-strength="1">前<br-fixation fixation-strength="2">瞻<br-fixation fixation-strength="3">性<br-edge>将2018<br-bold><br-fixation fixation-strength="1">年2<br-bold><br-fixation fixation-strength="1">月-2022<br-bold><br-fixation fixation-strength="1">年1<br-bold><br-fixation fixation-strength="1">月在<br-fixation fixation-strength="2">本院<br-fixation fixation-strength="3">就<br-fixation fixation-strength="4"><br-edge>诊的58<br-bold><br-fixation fixation-strength="1">例<br-fixation fixation-strength="2">伴<br-fixation fixation-strength="3">自<br-fixation fixation-strength="4">杀<br-edge>意念(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">I<br-fixation fixation-strength="3">组)<br-bold><br-fixation fixation-strength="1">和42<br-bold><br-fixation fixation-strength="1">例不伴<br-fixation fixation-strength="2">自杀意<br-fixation fixation-strength="3">念的抑<br-fixation fixation-strength="4"><br-edge>郁症患者(<br-bold><br-fixation fixation-strength="1">N<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">I<br-edge>组)<br-bold><br-fixation fixation-strength="1">以<br-fixation fixation-strength="2">及49<br-bold><br-fixation fixation-strength="1">例相<br-fixation fixation-strength="2">匹配<br-fixation fixation-strength="3">的健<br-fixation fixation-strength="4">康<br-edge>志愿者(<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">C<br-fixation fixation-strength="3">组)<br-bold><br-fixation fixation-strength="1">纳<br-fixation fixation-strength="2">入<br-fixation fixation-strength="3">本<br-fixation fixation-strength="4">研<br-edge>究,<br-bold><br-fixation fixation-strength="1">对所有<br-fixation fixation-strength="2">被试行<br-fixation fixation-strength="3">静息态<br-fixation fixation-strength="4">fM<br-edge>RI扫描。<br-bold><br-fixation fixation-strength="1">分别<br-fixation fixation-strength="2">在双<br-fixation fixation-strength="3">侧小<br-fixation fixation-strength="4">脑的<br-edge>Crus-Ⅰ、-Ⅱ、-Ⅴ、-Ⅵ<br-bold><br-fixation fixation-strength="1">和蚓<br-fixation fixation-strength="2">部勾<br-fixation fixation-strength="3">画R<br-fixation fixation-strength="4"><br-edge>OI,<br-bold><br-fixation fixation-strength="1">采用基于种子<br-fixation fixation-strength="2">点的FC分析<br-fixation fixation-strength="3">方法计算抑郁<br-fixation fixation-strength="4">症患者小脑各<br-edge>ROI与大脑的FC值。<br-bold><br-fixation fixation-strength="1">对所有抑<br-fixation fixation-strength="2">郁症患者<br-fixation fixation-strength="3">进行抑郁<br-fixation fixation-strength="4">相关的<br-edge>临床量表评估,<br-bold><br-fixation fixation-strength="1">包<br-fixation fixation-strength="2">括24<br-bold><br-fixation fixation-strength="1">项汉<br-fixation fixation-strength="2">密尔<br-fixation fixation-strength="3">顿抑<br-fixation fixation-strength="4"><br-edge>郁量表(<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">M<br-edge>D24)<br-bold><br-fixation fixation-strength="1">和Be<br-fixation fixation-strength="2">ck自<br-fixation fixation-strength="3">杀意念<br-fixation fixation-strength="4">量<br-edge>表中文版(<br-bold><br-fixation fixation-strength="1">B<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">I-<br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">V),<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">M<br-edge>D24<br-bold><br-fixation fixation-strength="1">评分<br-fixation fixation-strength="2">包括<br-fixation fixation-strength="3">HA<br-fixation fixation-strength="4"><br-edge>MD24<br-bold><br-fixation fixation-strength="1">总<br-fixation fixation-strength="2">分<br-fixation fixation-strength="3">及<br-fixation fixation-strength="4">焦<br-edge>虑/<br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">化、<br-bold><br-fixation fixation-strength="1">体<br-fixation fixation-strength="2">质<br-fixation fixation-strength="3">量、<br-bold><br-fixation fixation-strength="1">认<br-fixation fixation-strength="2">知<br-fixation fixation-strength="3">障<br-edge>碍、<br-bold><br-fixation fixation-strength="1">日<br-fixation fixation-strength="2">夜<br-fixation fixation-strength="3">变<br-edge>化、<br-bold><br-fixation fixation-strength="1">阻<br-fixation fixation-strength="2">滞、<br-bold><br-fixation fixation-strength="1">睡眠<br-fixation fixation-strength="2">障碍<br-fixation fixation-strength="3">和绝<br-fixation fixation-strength="4"><br-edge>望感共7<br-bold><br-fixation fixation-strength="1">项<br-fixation fixation-strength="2">因<br-fixation fixation-strength="3">子<br-fixation fixation-strength="4">的<br-edge>评分；<br-bold><br-fixation fixation-strength="1">B<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">I-<br-bold><br-fixation fixation-strength="1">CV评分<br-fixation fixation-strength="2">包括自杀<br-fixation fixation-strength="3">意念因子<br-fixation fixation-strength="4">和自杀危<br-edge>险因子两项评分。<br-bold><br-fixation fixation-strength="1">采用Pears<br-fixation fixation-strength="2">on或Spea<br-fixation fixation-strength="3">rman相关分<br-fixation fixation-strength="4">析对组间<br-edge>差异有统计学意义的小脑-<br-bold><br-fixation fixation-strength="1">大<br-fixation fixation-strength="2">脑<br-fixation fixation-strength="3">F<br-fixation fixation-strength="4">C<br-edge>值(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">I<br-fixation fixation-strength="3">组、<br-bold><br-fixation fixation-strength="1">NS<br-fixation fixation-strength="2">I组<br-fixation fixation-strength="3">和H<br-fixation fixation-strength="4">C组<br-edge>两两比较)<br-bold><br-fixation fixation-strength="1">与<br-fixation fixation-strength="2">临<br-fixation fixation-strength="3">床<br-fixation fixation-strength="4">变<br-edge>量(<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">程、<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">M<br-edge>D24<br-bold><br-fixation fixation-strength="1">评<br-fixation fixation-strength="2">分<br-fixation fixation-strength="3">和<br-fixation fixation-strength="4">B<br-edge>SI-<br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">V<br-fixation fixation-strength="3">评<br-edge>分)<br-bold><br-fixation fixation-strength="1">进行<br-fixation fixation-strength="2">相关<br-fixation fixation-strength="3">性<br-fixation fixation-strength="4"><br-edge>分析。<br-bold><br-fixation fixation-strength="1">结<br-fixation fixation-strength="2">果:<br-bold><br-fixation fixation-strength="1">与<br-fixation fixation-strength="2">H<br-fixation fixation-strength="3">C<br-fixation fixation-strength="4">组<br-edge>相比,<br-bold><br-fixation fixation-strength="1">SI组<br-fixation fixation-strength="2">和NS<br-fixation fixation-strength="3">I组的<br-fixation fixation-strength="4">小脑<br-edge>与颞上回、<br-bold><br-fixation fixation-strength="1">中<br-fixation fixation-strength="2">央<br-fixation fixation-strength="3">前<br-edge>回、<br-bold><br-fixation fixation-strength="1">中<br-fixation fixation-strength="2">央<br-fixation fixation-strength="3">钩<br-edge>盖、<br-bold><br-fixation fixation-strength="1">中央<br-fixation fixation-strength="2">旁小<br-fixation fixation-strength="3">叶的<br-fixation fixation-strength="4">FC<br-edge>值升高,<br-bold><br-fixation fixation-strength="1">小<br-fixation fixation-strength="2">脑<br-fixation fixation-strength="3">与<br-fixation fixation-strength="4">额<br-edge>中回、<br-bold><br-fixation fixation-strength="1">颞<br-fixation fixation-strength="2">叶、<br-bold><br-fixation fixation-strength="1">角回和<br-fixation fixation-strength="2">后扣带<br-fixation fixation-strength="3">回的F<br-fixation fixation-strength="4"><br-edge>C值降低；<br-bold><br-fixation fixation-strength="1">与N<br-fixation fixation-strength="2">SI<br-fixation fixation-strength="3">组<br-fixation fixation-strength="4"><br-edge>相比,<br-bold><br-fixation fixation-strength="1">SI组的<br-fixation fixation-strength="2">小脑与颞<br-fixation fixation-strength="3">中回和颞<br-fixation fixation-strength="4">下回<br-edge>的FC值升高,<br-bold><br-fixation fixation-strength="1">与右<br-fixation fixation-strength="2">侧角<br-fixation fixation-strength="3">回的<br-fixation fixation-strength="4">FC<br-edge>值降低。<br-bold><br-fixation fixation-strength="1">右侧<br-fixation fixation-strength="2">小脑<br-fixation fixation-strength="3">Cr<br-fixation fixation-strength="4"><br-edge>us-Ⅰ<br-bold><br-fixation fixation-strength="1">与大脑<br-fixation fixation-strength="2">间的F<br-fixation fixation-strength="3">C值与<br-fixation fixation-strength="4"><br-edge>HAMD24<br-bold><br-fixation fixation-strength="1">总<br-fixation fixation-strength="2">分<br-fixation fixation-strength="3">及<br-fixation fixation-strength="4">阻<br-edge>滞、<br-bold><br-fixation fixation-strength="1">体<br-fixation fixation-strength="2">质<br-fixation fixation-strength="3">量、<br-bold><br-fixation fixation-strength="1">日夜变化<br-fixation fixation-strength="2">和认知障<br-fixation fixation-strength="3">碍四项因<br-fixation fixation-strength="4">子的评<br-edge>分均呈负相关(<br-bold><br-fixation fixation-strength="1">r=-0.308、-0.315、-0.273、-0.311、-0.263,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">均<br-fixation fixation-strength="1">左侧<br-fixation fixation-strength="2">小脑<br-fixation fixation-strength="3">Cr<br-fixation fixation-strength="4"><br-edge>us-Ⅰ<br-bold><br-fixation fixation-strength="1">与额中回和<br-fixation fixation-strength="2">后扣带回的<br-fixation fixation-strength="3">FC值与体<br-fixation fixation-strength="4">质量因子评<br-edge>分之间均呈负相关(<br-bold><br-fixation fixation-strength="1">r=-0.295、-0.289,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">均<br-fixation fixation-strength="1">左侧<br-fixation fixation-strength="2">小脑<br-fixation fixation-strength="3">Cr<br-fixation fixation-strength="4"><br-edge>us-Ⅰ<br-bold><br-fixation fixation-strength="1">与颞上回<br-fixation fixation-strength="2">的FC值<br-fixation fixation-strength="3">与自杀危<br-fixation fixation-strength="4">险因子<br-edge>评分呈负相关(<br-bold><br-fixation fixation-strength="1">r=-0.277,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">左侧<br-fixation fixation-strength="2">小脑<br-fixation fixation-strength="3">Cr<br-fixation fixation-strength="4"><br-edge>us-Ⅰ<br-bold><br-fixation fixation-strength="1">与中央钩<br-fixation fixation-strength="2">盖的FC<br-fixation fixation-strength="3">值与体质<br-fixation fixation-strength="4">量因子<br-edge>评分呈正相关(<br-bold><br-fixation fixation-strength="1">r=0.278,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">左侧<br-fixation fixation-strength="2">小脑<br-fixation fixation-strength="3">Cr<br-fixation fixation-strength="4"><br-edge>us-Ⅰ<br-bold><br-fixation fixation-strength="1">与中央旁<br-fixation fixation-strength="2">小叶的F<br-fixation fixation-strength="3">C值与睡<br-fixation fixation-strength="4">眠障碍因<br-edge>子评分呈正相关(<br-bold><br-fixation fixation-strength="1">r=0.382,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">结<br-fixation fixation-strength="2">论:<br-bold><br-fixation fixation-strength="1">静息态fMRI<br-fixation fixation-strength="2">证实伴自杀意念<br-fixation fixation-strength="3">的抑郁症患者的<br-fixation fixation-strength="4">小脑与大脑之<br-edge>间的功能连接出现了紊乱,<br-bold><br-fixation fixation-strength="1">主要发<br-fixation fixation-strength="2">生于执<br-fixation fixation-strength="3">行网络<br-fixation fixation-strength="4">和默<br-edge>认模式网络,<br-bold><br-fixation fixation-strength="1">从而为伴自<br-fixation fixation-strength="2">杀意念抑郁<br-fixation fixation-strength="3">症患者发病<br-fixation fixation-strength="4">机制的<br-edge>研究提供了新思路。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7111848395
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 2
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">国家<br-fixation fixation-strength="2">自然<br-fixation fixation-strength="3">科学<br-fixation fixation-strength="4">基<br-edge>金项目(81601467,81871327,62106229)。



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">以躯体症状<br-fixation fixation-strength="2">为突出表现<br-fixation fixation-strength="3">的神经症的<br-fixation fixation-strength="4">神经<br-edge>影像学研究进展
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">毛<br-fixation fixation-strength="2">永<br-fixation fixation-strength="3">军
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">贾<br-fixation fixation-strength="2">剑<br-fixation fixation-strength="3">锋
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">内蒙古<br-fixation fixation-strength="2">医学院<br-fixation fixation-strength="3">附属医<br-fixation fixation-strength="4">院<br-edge>神经内科,<br-bold><br-fixation fixation-strength="1">内蒙<br-fixation fixation-strength="2">古呼<br-fixation fixation-strength="3">和<br-fixation fixation-strength="4"><br-edge>浩特010055
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">内蒙古<br-fixation fixation-strength="2">乌拉特<br-fixation fixation-strength="3">中旗哈<br-fixation fixation-strength="4">河中<br-edge>心医院内科,<br-bold><br-fixation fixation-strength="1">内<br-fixation fixation-strength="2">蒙<br-fixation fixation-strength="3">古<br-fixation fixation-strength="4">海<br-edge>流图015300
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1004-0951
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">内蒙<br-fixation fixation-strength="2">古医<br-fixation fixation-strength="3">学<br-fixation fixation-strength="4"><br-edge>杂志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2009
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 41
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 6
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 703-705
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">惊<br-fixation fixation-strength="2">恐<br-fixation fixation-strength="3">性<br-fixation fixation-strength="4">障<br-edge>碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">化<br-fixation fixation-strength="4">障<br-edge>碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">癔<br-fixation fixation-strength="2">病
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">神<br-fixation fixation-strength="2">经<br-fixation fixation-strength="3">影<br-edge>像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">E<br-fixation fixation-strength="3">T
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">P<br-fixation fixation-strength="3">E<br-fixation fixation-strength="4">C<br-edge>T
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">神经影像技术的<br-fixation fixation-strength="2">快速发展及广泛<br-fixation fixation-strength="3">应用为神经症的<br-fixation fixation-strength="4">发病机制<br-edge>研究提供了有效的手段,<br-bold><br-fixation fixation-strength="1">研<br-fixation fixation-strength="2">究<br-fixation fixation-strength="3">发<br-edge>现,<br-bold><br-fixation fixation-strength="1">惊恐性<br-fixation fixation-strength="2">障碍患<br-fixation fixation-strength="3">者不仅<br-fixation fixation-strength="4">区域<br-edge>性脑血流(<br-bold><br-fixation fixation-strength="1">r<br-fixation fixation-strength="2">C<br-fixation fixation-strength="3">B<br-edge>F)<br-bold><br-fixation fixation-strength="1">及脑<br-fixation fixation-strength="2">葡萄<br-fixation fixation-strength="3">糖代<br-fixation fixation-strength="4">谢率<br-edge>出现异常,<br-bold><br-fixation fixation-strength="1">某些<br-fixation fixation-strength="2">脑结<br-fixation fixation-strength="3">构的<br-fixation fixation-strength="4">容积<br-edge>也有改变。<br-bold><br-fixation fixation-strength="1">与<br-fixation fixation-strength="2">健<br-fixation fixation-strength="3">康<br-fixation fixation-strength="4">者<br-edge>相比,<br-bold><br-fixation fixation-strength="1">惊恐<br-fixation fixation-strength="2">障碍<br-fixation fixation-strength="3">患<br-fixation fixation-strength="4"><br-edge>者额、<br-bold><br-fixation fixation-strength="1">颞、<br-bold><br-fixation fixation-strength="1">枕及左侧<br-fixation fixation-strength="2">海马等脑<br-fixation fixation-strength="3">区苯二氮<br-fixation fixation-strength="4">艹卓<br-edge>受体功能异常。<br-bold><br-fixation fixation-strength="1">病人<br-fixation fixation-strength="2">的前<br-fixation fixation-strength="3">扣<br-fixation fixation-strength="4"><br-edge>带回,<br-bold><br-fixation fixation-strength="1">后<br-fixation fixation-strength="2">扣<br-fixation fixation-strength="3">带<br-edge>回,<br-bold><br-fixation fixation-strength="1">和<br-fixation fixation-strength="2">缝<br-fixation fixation-strength="3">的5-<br-bold><br-fixation fixation-strength="1">羟<br-fixation fixation-strength="2">色<br-fixation fixation-strength="3">胺1<br-bold><br-fixation fixation-strength="1">A受<br-fixation fixation-strength="2">体容<br-fixation fixation-strength="3">积分<br-fixation fixation-strength="4">布明<br-edge>显减少。<br-bold><br-fixation fixation-strength="1">躯体化障<br-fixation fixation-strength="2">碍患者的<br-fixation fixation-strength="3">双侧尾状<br-fixation fixation-strength="4">核的<br-edge>体积明显增大,<br-bold><br-fixation fixation-strength="1">与<br-fixation fixation-strength="2">正<br-fixation fixation-strength="3">常<br-fixation fixation-strength="4">人<br-edge>相比,<br-bold><br-fixation fixation-strength="1">病人<br-fixation fixation-strength="2">的双<br-fixation fixation-strength="3">侧尾<br-fixation fixation-strength="4"><br-edge>状核,<br-bold><br-fixation fixation-strength="1">左侧壳核<br-fixation fixation-strength="2">和右侧中<br-fixation fixation-strength="3">央前回葡<br-fixation fixation-strength="4">萄糖脑<br-edge>代谢有明显降低。<br-bold><br-fixation fixation-strength="1">功能性神经影像技术<br-fixation fixation-strength="2">的研究发现在癔病瘫<br-fixation fixation-strength="3">痪时大脑额叶以及一<br-fixation fixation-strength="4">些参与运动控制的<br-edge>一些皮质下环路选择性的活动减低。<br-bold><br-fixation fixation-strength="1">在癔<br-fixation fixation-strength="2">病性<br-fixation fixation-strength="3">感觉<br-fixation fixation-strength="4"><br-edge>缺失,<br-bold><br-fixation fixation-strength="1">体感<br-fixation fixation-strength="2">觉皮<br-fixation fixation-strength="3">层的<br-fixation fixation-strength="4">活<br-edge>动减低。<br-bold><br-fixation fixation-strength="1">于癔<br-fixation fixation-strength="2">病性<br-fixation fixation-strength="3">失明<br-fixation fixation-strength="4"><br-edge>的病人,<br-bold><br-fixation fixation-strength="1">视觉<br-fixation fixation-strength="2">皮质<br-fixation fixation-strength="3">的活<br-fixation fixation-strength="4"><br-edge>动减低。<br-bold><br-fixation fixation-strength="1">用磁共振波谱分析<br-fixation fixation-strength="2">的方法研究躯体形<br-fixation fixation-strength="3">式疼痛障碍的脑生<br-fixation fixation-strength="4">化物质代谢<br-edge>在不同脑区域内的变化发现:<br-bold><br-fixation fixation-strength="1">躯体形式疼<br-fixation fixation-strength="2">痛障碍者的<br-fixation fixation-strength="3">优势半球丘<br-fixation fixation-strength="4">脑存在<br-edge>着神经元的受损,<br-bold><br-fixation fixation-strength="1">故优势半球<br-fixation fixation-strength="2">丘脑可能成<br-fixation fixation-strength="3">为躯体形式<br-fixation fixation-strength="4">疼痛障<br-edge>碍的功能定位区域。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=31093535
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 1



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: ^(18)<br-bold><br-fixation fixation-strength="1">F-<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">G <br-bold><br-fixation fixation-strength="1">PET脑<br-fixation fixation-strength="2">显像用于<br-fixation fixation-strength="3">恶性肿瘤<br-fixation fixation-strength="4">患<br-edge>者抑郁分析
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">苏<br-fixation fixation-strength="2">亮
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">传<br-fixation fixation-strength="3">涛
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">管<br-fixation fixation-strength="2">一<br-fixation fixation-strength="3">晖
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">赵<br-fixation fixation-strength="2">军
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">施<br-fixation fixation-strength="2">慎<br-fixation fixation-strength="3">逊
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">复旦大<br-fixation fixation-strength="2">学附属<br-fixation fixation-strength="3">华山医<br-fixation fixation-strength="4"><br-edge>院精神科,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海200040
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">复旦大<br-fixation fixation-strength="2">学附属<br-fixation fixation-strength="3">华山医<br-fixation fixation-strength="4">院P<br-edge>ET中心,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海200040
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 0253-9780
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">中华<br-fixation fixation-strength="2">核医<br-fixation fixation-strength="3">学<br-fixation fixation-strength="4"><br-edge>杂志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2005
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 25
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 3
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 159-161+<br-bold><br-fixation fixation-strength="1">i003
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">恶<br-fixation fixation-strength="2">性<br-fixation fixation-strength="3">肿<br-fixation fixation-strength="4">瘤<br-edge>患者
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">E<br-fixation fixation-strength="3">T<br-fixation fixation-strength="4">脑<br-edge>显像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: ^18<br-bold><br-fixation fixation-strength="1">F-<br-bold><br-fixation fixation-strength="1">脱<br-fixation fixation-strength="2">氧<br-fixation fixation-strength="3">葡<br-fixation fixation-strength="4">萄<br-edge>糖
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">脑^18<br-bold><br-fixation fixation-strength="1">F-<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">G
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">汉密<br-fixation fixation-strength="2">尔顿<br-fixation fixation-strength="3">抑郁<br-fixation fixation-strength="4"><br-edge>量表
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">抑<br-fixation fixation-strength="2">郁<br-fixation fixation-strength="3">情<br-edge>绪
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">抑<br-fixation fixation-strength="2">郁<br-fixation fixation-strength="3">自<br-fixation fixation-strength="4">评<br-edge>量表
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">脑<br-fixation fixation-strength="2">葡<br-fixation fixation-strength="3">萄<br-fixation fixation-strength="4">糖<br-edge>代谢
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">M<br-fixation fixation-strength="4">D<br-edge>量表
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">健<br-fixation fixation-strength="2">康<br-fixation fixation-strength="3">体<br-fixation fixation-strength="4">检<br-edge>者
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">E<br-fixation fixation-strength="3">T<br-fixation fixation-strength="4">显<br-edge>像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">统<br-fixation fixation-strength="2">计<br-fixation fixation-strength="3">参<br-fixation fixation-strength="4">数<br-edge>图
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">对<br-fixation fixation-strength="2">照<br-fixation fixation-strength="3">组
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">显<br-fixation fixation-strength="2">著<br-fixation fixation-strength="3">性
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">组<br-fixation fixation-strength="2">间<br-fixation fixation-strength="3">差
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">性<br-fixation fixation-strength="2">别<br-fixation fixation-strength="3">构<br-edge>成
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">认<br-fixation fixation-strength="2">知<br-fixation fixation-strength="3">障<br-edge>碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">睡<br-fixation fixation-strength="2">眠<br-fixation fixation-strength="3">障<br-edge>碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">后<br-fixation fixation-strength="2">扣<br-fixation fixation-strength="3">带<br-edge>回
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">前<br-fixation fixation-strength="2">扣<br-fixation fixation-strength="3">带<br-edge>回
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的探讨<br-fixation fixation-strength="2">非脑部恶<br-fixation fixation-strength="3">性肿瘤患<br-fixation fixation-strength="4">者的<br-edge>抑郁情绪及其18<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">脱<br-fixation fixation-strength="3">氧<br-fixation fixation-strength="4">葡<br-edge>萄糖(<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">G)<br-bold><br-fixation fixation-strength="1">PE<br-fixation fixation-strength="2">T脑<br-fixation fixation-strength="3">显像<br-fixation fixation-strength="4"><br-edge>的特点。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法<br-fixation fixation-strength="3">分<br-fixation fixation-strength="4">别<br-edge>对21<br-bold><br-fixation fixation-strength="1">例恶<br-fixation fixation-strength="2">性肿<br-fixation fixation-strength="3">瘤<br-fixation fixation-strength="4"><br-edge>患者(<br-bold><br-fixation fixation-strength="1">肿<br-fixation fixation-strength="2">瘤<br-fixation fixation-strength="3">组)<br-bold><br-fixation fixation-strength="1">及21<br-bold><br-fixation fixation-strength="1">例<br-fixation fixation-strength="2">健<br-fixation fixation-strength="3">康<br-fixation fixation-strength="4">体<br-edge>检者(<br-bold><br-fixation fixation-strength="1">对<br-fixation fixation-strength="2">照<br-fixation fixation-strength="3">组)<br-bold><br-fixation fixation-strength="1">行<br-fixation fixation-strength="2">脑18<br-bold><br-fixation fixation-strength="1">FF<br-fixation fixation-strength="2">DG<br-fixation fixation-strength="3">PE<br-fixation fixation-strength="4"><br-edge>T显像,<br-bold><br-fixation fixation-strength="1">年<br-fixation fixation-strength="2">龄、<br-bold><br-fixation fixation-strength="1">性<br-fixation fixation-strength="2">别<br-fixation fixation-strength="3">构<br-fixation fixation-strength="4">成<br-edge>配对,<br-bold><br-fixation fixation-strength="1">用抑<br-fixation fixation-strength="2">郁自<br-fixation fixation-strength="3">评<br-fixation fixation-strength="4"><br-edge>量表(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">S)、24<br-bold><br-fixation fixation-strength="1">项汉<br-fixation fixation-strength="2">密尔<br-fixation fixation-strength="3">顿抑<br-fixation fixation-strength="4"><br-edge>郁量表(<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">M<br-edge>D)<br-bold><br-fixation fixation-strength="1">对两<br-fixation fixation-strength="2">组进<br-fixation fixation-strength="3">行<br-fixation fixation-strength="4"><br-edge>评估。<br-bold><br-fixation fixation-strength="1">用<br-fixation fixation-strength="2">统<br-fixation fixation-strength="3">计<br-fixation fixation-strength="4">参<br-edge>数图(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">P<br-fixation fixation-strength="3">M2)<br-bold><br-fixation fixation-strength="1">软件比较<br-fixation fixation-strength="2">肿瘤组和<br-fixation fixation-strength="3">对照组脑<br-fixation fixation-strength="4">葡萄<br-edge>糖代谢的差别。<br-bold><br-fixation fixation-strength="1">结果SDS<br-fixation fixation-strength="2">标准总分和<br-fixation fixation-strength="3">HAMD总<br-fixation fixation-strength="4">分两组<br-edge>间差异有显著性(<br-bold><br-fixation fixation-strength="1">P0.05),<br-bold><br-fixation fixation-strength="1">焦<br-fixation fixation-strength="2">虑<br-fixation fixation-strength="3">躯<br-fixation fixation-strength="4">体<br-edge>化、<br-bold><br-fixation fixation-strength="1">体<br-fixation fixation-strength="2">重、<br-bold><br-fixation fixation-strength="1">阻<br-fixation fixation-strength="2">滞、<br-bold><br-fixation fixation-strength="1">睡眠<br-fixation fixation-strength="2">障碍<br-fixation fixation-strength="3">和绝<br-fixation fixation-strength="4"><br-edge>望感5<br-bold><br-fixation fixation-strength="1">项因子<br-fixation fixation-strength="2">分两组<br-fixation fixation-strength="3">间差异<br-fixation fixation-strength="4"><br-edge>有显著性(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">均<br-fixation fixation-strength="1">SPM分<br-fixation fixation-strength="2">析显示肿<br-fixation fixation-strength="3">瘤组较对<br-fixation fixation-strength="4">照<br-edge>组左侧颞下回、<br-bold><br-fixation fixation-strength="1">颞<br-fixation fixation-strength="2">上<br-fixation fixation-strength="3">回、<br-bold><br-fixation fixation-strength="1">后<br-fixation fixation-strength="2">扣<br-fixation fixation-strength="3">带<br-edge>回、<br-bold><br-fixation fixation-strength="1">颞<br-fixation fixation-strength="2">中<br-fixation fixation-strength="3">回、<br-bold><br-fixation fixation-strength="1">角<br-fixation fixation-strength="2">回、<br-bold><br-fixation fixation-strength="1">楔叶<br-fixation fixation-strength="2">及右<br-fixation fixation-strength="3">侧前<br-fixation fixation-strength="4"><br-edge>扣带回、<br-bold><br-fixation fixation-strength="1">额中回<br-fixation fixation-strength="2">和双侧<br-fixation fixation-strength="3">额下回<br-fixation fixation-strength="4">葡萄<br-edge>糖代谢减低。<br-bold><br-fixation fixation-strength="1">结论恶<br-fixation fixation-strength="2">性肿瘤<br-fixation fixation-strength="3">患者存<br-fixation fixation-strength="4">在<br-edge>抑郁情绪,18<br-bold><br-fixation fixation-strength="1">FFDGPE<br-fixation fixation-strength="2">T脑显像提示<br-fixation fixation-strength="3">的局部葡萄糖<br-fixation fixation-strength="4">代谢下降<br-edge>可能与抑郁情绪相关。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=15853334
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 6



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">首发抑郁症<br-fixation fixation-strength="2">局部脑区的<br-fixation fixation-strength="3">功能一致性<br-fixation fixation-strength="4">及其与<br-edge>临床症状的关系
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">彭<br-fixation fixation-strength="2">代<br-fixation fixation-strength="3">辉
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">江<br-fixation fixation-strength="2">开<br-fixation fixation-strength="3">达
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">贻<br-fixation fixation-strength="3">儒
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">徐<br-fixation fixation-strength="2">一<br-fixation fixation-strength="3">峰
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">刘<br-fixation fixation-strength="2">军
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">上海交<br-fixation fixation-strength="2">通大学<br-fixation fixation-strength="3">医学院<br-fixation fixation-strength="4">附属精<br-edge>神卫生中心,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海200030
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">上海<br-fixation fixation-strength="2">普陀<br-fixation fixation-strength="3">区中<br-fixation fixation-strength="4"><br-edge>心医院
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">复旦大<br-fixation fixation-strength="2">学附属<br-fixation fixation-strength="3">华山医<br-fixation fixation-strength="4"><br-edge>院放射科
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1002-0152
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">中国<br-fixation fixation-strength="2">神经<br-fixation fixation-strength="3">精神<br-fixation fixation-strength="4">疾<br-edge>病杂志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2010
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 36
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 7
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 406-409
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">抑<br-fixation fixation-strength="2">郁<br-fixation fixation-strength="3">症
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">功<br-fixation fixation-strength="2">能<br-fixation fixation-strength="3">磁<br-fixation fixation-strength="4">共<br-edge>振
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">静<br-fixation fixation-strength="2">息<br-fixation fixation-strength="3">态
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">局<br-fixation fixation-strength="2">部<br-fixation fixation-strength="3">一<br-fixation fixation-strength="4">致<br-edge>性
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">临<br-fixation fixation-strength="2">床<br-fixation fixation-strength="3">症<br-edge>状
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的<br-fixation fixation-strength="2">通过<br-fixation fixation-strength="3">静息<br-fixation fixation-strength="4">态功<br-edge>能磁共振(<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-edge>I),<br-bold><br-fixation fixation-strength="1">探讨首发抑<br-fixation fixation-strength="2">郁症患者的<br-fixation fixation-strength="3">自发脑活动<br-fixation fixation-strength="4">特征及其与<br-edge>临床症状之间的关系。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法 16<br-bold><br-fixation fixation-strength="1">例首<br-fixation fixation-strength="2">发未<br-fixation fixation-strength="3">用药<br-fixation fixation-strength="4">的符<br-edge>合DSM-<br-bold><br-fixation fixation-strength="1">IV诊<br-fixation fixation-strength="2">断标准<br-fixation fixation-strength="3">的重性<br-fixation fixation-strength="4"><br-edge>抑郁障碍(<br-bold><br-fixation fixation-strength="1">抑<br-fixation fixation-strength="2">郁<br-fixation fixation-strength="3">症)<br-bold><br-fixation fixation-strength="1">患<br-fixation fixation-strength="2">者<br-fixation fixation-strength="3">和16<br-bold><br-fixation fixation-strength="1">名<br-fixation fixation-strength="2">正<br-fixation fixation-strength="3">常<br-fixation fixation-strength="4">对<br-edge>照,<br-bold><br-fixation fixation-strength="1">在静<br-fixation fixation-strength="2">息状<br-fixation fixation-strength="3">态下<br-fixation fixation-strength="4"><br-edge>接受5<br-bold><br-fixation fixation-strength="1">m<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">n12<br-bold><br-fixation fixation-strength="1">sf<br-fixation fixation-strength="2">MR<br-fixation fixation-strength="3">I<br-fixation fixation-strength="4"><br-edge>扫描。<br-bold><br-fixation fixation-strength="1">以汉<br-fixation fixation-strength="2">密尔<br-fixation fixation-strength="3">顿抑<br-fixation fixation-strength="4"><br-edge>郁量表(<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">M<br-edge>D)<br-bold><br-fixation fixation-strength="1">评估<br-fixation fixation-strength="2">患者<br-fixation fixation-strength="3">临床<br-fixation fixation-strength="4"><br-edge>症状,<br-bold><br-fixation fixation-strength="1">以ReHo软<br-fixation fixation-strength="2">件对影像数据<br-fixation fixation-strength="3">进行脑区的自<br-fixation fixation-strength="4">发神经<br-edge>活动功能一致性分析。<br-bold><br-fixation fixation-strength="1">结果<br-fixation fixation-strength="2">患者<br-fixation fixation-strength="3">组左<br-fixation fixation-strength="4"><br-edge>侧丘脑、<br-bold><br-fixation fixation-strength="1">左内<br-fixation fixation-strength="2">外侧<br-fixation fixation-strength="3">上<br-fixation fixation-strength="4"><br-edge>颞叶、<br-bold><br-fixation fixation-strength="1">左侧小脑<br-fixation fixation-strength="2">与枕叶的<br-fixation fixation-strength="3">自发活动<br-fixation fixation-strength="4">局部一致<br-edge>性较对照组减低(<br-bold><br-fixation fixation-strength="1">P0.05),<br-bold><br-fixation fixation-strength="1">但左侧丘<br-fixation fixation-strength="2">脑ReH<br-fixation fixation-strength="3">o值与H<br-fixation fixation-strength="4">AM<br-edge>D体重因子分、<br-bold><br-fixation fixation-strength="1">睡眠<br-fixation fixation-strength="2">障碍<br-fixation fixation-strength="3">因子<br-fixation fixation-strength="4"><br-edge>分相关(<br-bold><br-fixation fixation-strength="1">r=0.56,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">r=0.58,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">左外侧上颞<br-fixation fixation-strength="2">叶ReHo<br-fixation fixation-strength="3">值与HAM<br-fixation fixation-strength="4">D认知<br-edge>障碍因子分相关(<br-bold><br-fixation fixation-strength="1">r=0.51,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">左内侧上颞<br-fixation fixation-strength="2">叶ReHo<br-fixation fixation-strength="3">值与HAM<br-fixation fixation-strength="4">D焦<br-edge>虑躯体化因子分、<br-bold><br-fixation fixation-strength="1">认知<br-fixation fixation-strength="2">障碍<br-fixation fixation-strength="3">因子<br-fixation fixation-strength="4"><br-edge>分相关(<br-bold><br-fixation fixation-strength="1">r=0.51,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">r=0.53,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">结论首<br-fixation fixation-strength="2">发抑郁<br-fixation fixation-strength="3">症患者<br-fixation fixation-strength="4"><br-edge>左侧丘脑、<br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">侧<br-fixation fixation-strength="3">上<br-fixation fixation-strength="4">颞<br-edge>叶、<br-bold><br-fixation fixation-strength="1">左侧<br-fixation fixation-strength="2">小脑<br-fixation fixation-strength="3">与枕<br-fixation fixation-strength="4">叶功<br-edge>能异常,<br-bold><br-fixation fixation-strength="1">且部分脑区<br-fixation fixation-strength="2">自发活动一<br-fixation fixation-strength="3">致性降低可<br-fixation fixation-strength="4">能与患<br-edge>者某些症状相关。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=34743694
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 13
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">上海<br-fixation fixation-strength="2">市自<br-fixation fixation-strength="3">然科<br-fixation fixation-strength="4">学基<br-edge>金项目(<br-bold><br-fixation fixation-strength="1">编<br-fixation fixation-strength="2">号:09<br-bold><br-fixation fixation-strength="1">Z<br-fixation fixation-strength="2">R1427200)



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">首发抑郁<br-fixation fixation-strength="2">障碍伴躯<br-fixation fixation-strength="3">体疼痛患<br-fixation fixation-strength="4">者的感觉<br-edge>运动区功能改变
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">梁<br-fixation fixation-strength="2">嘉<br-fixation fixation-strength="3">权
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">陆<br-fixation fixation-strength="2">小<br-fixation fixation-strength="3">兵
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">徐<br-fixation fixation-strength="2">彩<br-fixation fixation-strength="3">霞
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">许<br-fixation fixation-strength="2">珍<br-fixation fixation-strength="3">玉
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">陈<br-fixation fixation-strength="2">海<br-fixation fixation-strength="3">霞
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">廖<br-fixation fixation-strength="2">海<br-fixation fixation-strength="3">容
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">梁<br-fixation fixation-strength="2">美<br-fixation fixation-strength="3">红
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">吕<br-fixation fixation-strength="2">艳<br-fixation fixation-strength="3">丽
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">周<br-fixation fixation-strength="2">慧
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">叶<br-fixation fixation-strength="2">婵
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">广<br-fixation fixation-strength="2">州<br-fixation fixation-strength="3">医<br-fixation fixation-strength="4">科<br-edge>大学,<br-bold><br-fixation fixation-strength="1">广<br-fixation fixation-strength="2">州511436
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">广州<br-fixation fixation-strength="2">医科<br-fixation fixation-strength="3">大学<br-fixation fixation-strength="4">附属<br-edge>脑科医院(<br-bold><br-fixation fixation-strength="1">广州<br-fixation fixation-strength="2">市惠<br-fixation fixation-strength="3">爱<br-fixation fixation-strength="4"><br-edge>医院)
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">佛山<br-fixation fixation-strength="2">市第<br-fixation fixation-strength="3">三人<br-fixation fixation-strength="4"><br-edge>民医院
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">广东省精<br-fixation fixation-strength="2">神疾病转<br-fixation fixation-strength="3">化医学工<br-fixation fixation-strength="4">程<br-edge>技术研究中心
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1673-2952
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">国际<br-fixation fixation-strength="2">精神<br-fixation fixation-strength="3">病学<br-fixation fixation-strength="4"><br-edge>杂志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2020
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 47
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 2
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 257-261
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">抑<br-fixation fixation-strength="2">郁<br-fixation fixation-strength="3">障<br-edge>碍
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">疼<br-fixation fixation-strength="2">痛
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">核<br-fixation fixation-strength="2">磁<br-fixation fixation-strength="3">共<br-fixation fixation-strength="4">振<br-edge>成像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">局<br-fixation fixation-strength="2">部<br-fixation fixation-strength="3">一<br-fixation fixation-strength="4">致<br-edge>性
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的利<br-fixation fixation-strength="2">用静息<br-fixation fixation-strength="3">态功能<br-fixation fixation-strength="4">磁<br-edge>共振成像(<br-bold><br-fixation fixation-strength="1">re<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">i<br-fixation fixation-strength="4"><br-edge>ng-<br-bold><br-fixation fixation-strength="1">s<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">a<br-fixation fixation-strength="4">t<br-edge>e <br-bold><br-fixation fixation-strength="1">fu<br-fixation fixation-strength="2">nc<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4">o<br-edge>nal <br-bold><br-fixation fixation-strength="1">M<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">I,<br-bold><br-fixation fixation-strength="1">r<br-fixation fixation-strength="2">s-<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-edge>I)<br-bold><br-fixation fixation-strength="1">技<br-fixation fixation-strength="2">术,<br-bold><br-fixation fixation-strength="1">探索伴有躯体疼<br-fixation fixation-strength="2">痛的抑郁症患者<br-fixation fixation-strength="3">异常脑功能活动<br-fixation fixation-strength="4">区域及抑郁症<br-edge>状与躯体疼痛症状的关系。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法<br-fixation fixation-strength="3">对32<br-bold><br-fixation fixation-strength="1">例首<br-fixation fixation-strength="2">发抑<br-fixation fixation-strength="3">郁障<br-fixation fixation-strength="4"><br-edge>碍患者(16<br-bold><br-fixation fixation-strength="1">例伴<br-fixation fixation-strength="2">有躯<br-fixation fixation-strength="3">体<br-fixation fixation-strength="4"><br-edge>疼痛、16<br-bold><br-fixation fixation-strength="1">例不<br-fixation fixation-strength="2">伴有<br-fixation fixation-strength="3">躯体<br-fixation fixation-strength="4"><br-edge>疼痛)<br-bold><br-fixation fixation-strength="1">进<br-fixation fixation-strength="2">行<br-fixation fixation-strength="3">r<br-edge>s-<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-fixation fixation-strength="4">I<br-edge>扫描。<br-bold><br-fixation fixation-strength="1">使用<br-fixation fixation-strength="2">局部<br-fixation fixation-strength="3">一<br-fixation fixation-strength="4"><br-edge>致性(<br-bold><br-fixation fixation-strength="1">re<br-fixation fixation-strength="2">gi<br-fixation fixation-strength="3">on<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">ho<br-fixation fixation-strength="2">mo<br-fixation fixation-strength="3">ge<br-fixation fixation-strength="4">ne<br-edge>ity,<br-bold><br-fixation fixation-strength="1">R<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">H<br-edge>o)<br-bold><br-fixation fixation-strength="1">方法分析ReH<br-fixation fixation-strength="2">o在伴有躯体疼<br-fixation fixation-strength="3">痛的抑郁障碍组<br-fixation fixation-strength="4">与不伴有躯体<br-edge>疼痛的抑郁障碍组之间差异。<br-bold><br-fixation fixation-strength="1">结果抑郁障<br-fixation fixation-strength="2">碍伴有躯体<br-fixation fixation-strength="3">疼痛的左侧<br-fixation fixation-strength="4">中央后<br-edge>回和左侧中央前回(<br-bold><br-fixation fixation-strength="1">感<br-fixation fixation-strength="2">觉<br-fixation fixation-strength="3">运<br-fixation fixation-strength="4">动<br-edge>区)<br-bold><br-fixation fixation-strength="1">ReH<br-fixation fixation-strength="2">o显著<br-fixation fixation-strength="3">高于不<br-fixation fixation-strength="4">伴有躯<br-edge>体疼痛患者(<br-bold><br-fixation fixation-strength="1">t左<br-fixation fixation-strength="2">侧中<br-fixation fixation-strength="3">央<br-fixation fixation-strength="4"><br-edge>后回=4.93,<br-bold><br-fixation fixation-strength="1">P左<br-fixation fixation-strength="2">侧中<br-fixation fixation-strength="3">央<br-fixation fixation-strength="4"><br-edge>后回<br-fixation fixation-strength="1">t左<br-fixation fixation-strength="2">侧中<br-fixation fixation-strength="3">央<br-fixation fixation-strength="4"><br-edge>前回=4.57,<br-bold><br-fixation fixation-strength="1">P左<br-fixation fixation-strength="2">侧中<br-fixation fixation-strength="3">央<br-fixation fixation-strength="4"><br-edge>前回<br-fixation fixation-strength="1">且简<br-fixation fixation-strength="2">明疼<br-fixation fixation-strength="3">痛<br-fixation fixation-strength="4"><br-edge>量表(<br-bold><br-fixation fixation-strength="1">B<br-fixation fixation-strength="2">P<br-fixation fixation-strength="3">I)<br-bold><br-fixation fixation-strength="1">平均疼痛<br-fixation fixation-strength="2">分与左侧<br-fixation fixation-strength="3">中央后回<br-fixation fixation-strength="4">脑区Re<br-edge>Ho值呈正相关(<br-bold><br-fixation fixation-strength="1">r=0.544,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">与左侧中<br-fixation fixation-strength="2">央前回脑<br-fixation fixation-strength="3">区ReH<br-fixation fixation-strength="4">o<br-edge>值呈正相关(<br-bold><br-fixation fixation-strength="1">r=0.550,<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">结论感觉运动<br-fixation fixation-strength="2">区局部一致性<br-fixation fixation-strength="3">改变在伴有躯<br-fixation fixation-strength="4">体疼痛的抑<br-edge>郁症患者中起重要作用。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7101912413
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 5
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">国家<br-fixation fixation-strength="2">自然<br-fixation fixation-strength="3">科学<br-fixation fixation-strength="4"><br-edge>基金:<br-bold><br-fixation fixation-strength="1">肝郁证的<br-fixation fixation-strength="2">影像遗传<br-fixation fixation-strength="3">学与基因<br-fixation fixation-strength="4">调<br-edge>控网络研究(<br-bold><br-fixation fixation-strength="1">编<br-fixation fixation-strength="2">号:81230085)；<br-bold><br-fixation fixation-strength="1">佛山<br-fixation fixation-strength="2">市十<br-fixation fixation-strength="3">三五<br-fixation fixation-strength="4">医学<br-edge>特色专科(<br-bold><br-fixation fixation-strength="1">编<br-fixation fixation-strength="2">号:<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">T<br-fixation fixation-strength="4">S<br-edge>ZK002)。



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">针刺治疗抑<br-fixation fixation-strength="2">郁症脑中枢<br-fixation fixation-strength="3">机制的功能<br-fixation fixation-strength="4">磁共<br-edge>振成像研究进展
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">李<br-fixation fixation-strength="2">晓<br-fixation fixation-strength="3">陵
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">刘<br-fixation fixation-strength="2">晓<br-fixation fixation-strength="3">慧
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">李<br-fixation fixation-strength="2">昂
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">王<br-fixation fixation-strength="2">丰
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">曹<br-fixation fixation-strength="2">丹<br-fixation fixation-strength="3">娜
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">姜<br-fixation fixation-strength="2">晓<br-fixation fixation-strength="3">旭
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">蔡<br-fixation fixation-strength="2">丽<br-fixation fixation-strength="3">娜
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">杨<br-fixation fixation-strength="2">旭
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">刘<br-fixation fixation-strength="2">阳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">黑龙江<br-fixation fixation-strength="2">中医药<br-fixation fixation-strength="3">大学附<br-fixation fixation-strength="4">属<br-edge>第一医院,<br-bold><br-fixation fixation-strength="1">黑<br-fixation fixation-strength="2">龙<br-fixation fixation-strength="3">江<br-fixation fixation-strength="4">哈<br-edge>尔滨150040
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">黑龙<br-fixation fixation-strength="2">江中<br-fixation fixation-strength="3">医药<br-fixation fixation-strength="4">大学<br-edge>研究生院,<br-bold><br-fixation fixation-strength="1">黑<br-fixation fixation-strength="2">龙<br-fixation fixation-strength="3">江<br-fixation fixation-strength="4">哈<br-edge>尔滨150040
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">哈尔滨<br-fixation fixation-strength="2">医科大<br-fixation fixation-strength="3">学公共<br-fixation fixation-strength="4"><br-edge>卫生学院,<br-bold><br-fixation fixation-strength="1">黑<br-fixation fixation-strength="2">龙<br-fixation fixation-strength="3">江<br-fixation fixation-strength="4">哈<br-edge>尔滨150081
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1672-951<br-bold><br-fixation fixation-strength="1">X
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">中<br-fixation fixation-strength="2">医<br-fixation fixation-strength="3">药<br-fixation fixation-strength="4">导<br-edge>报
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2021
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 27
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 5
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 138-141+146
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">抑<br-fixation fixation-strength="2">郁<br-fixation fixation-strength="3">症
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">磁<br-fixation fixation-strength="2">共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4">成<br-edge>像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">针<br-fixation fixation-strength="2">刺
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">脑<br-fixation fixation-strength="2">网<br-fixation fixation-strength="3">络
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">综<br-fixation fixation-strength="2">述
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">通过查阅近年运<br-fixation fixation-strength="2">用功能磁共振成<br-fixation fixation-strength="3">像技术探讨抑郁<br-fixation fixation-strength="4">症诊断及针<br-edge>刺治疗疗效等方面的研究,<br-bold><br-fixation fixation-strength="1">从不同的<br-fixation fixation-strength="2">针刺和成<br-fixation fixation-strength="3">像方法对<br-fixation fixation-strength="4">文<br-edge>献进行筛选、<br-bold><br-fixation fixation-strength="1">归<br-fixation fixation-strength="2">纳、<br-bold><br-fixation fixation-strength="1">总<br-fixation fixation-strength="2">结,<br-bold><br-fixation fixation-strength="1">认为针<br-fixation fixation-strength="2">刺对于<br-fixation fixation-strength="3">抑郁症<br-fixation fixation-strength="4">的治<br-edge>疗作用明确,<br-bold><br-fixation fixation-strength="1">能够<br-fixation fixation-strength="2">明显<br-fixation fixation-strength="3">改善<br-fixation fixation-strength="4"><br-edge>焦虑、<br-bold><br-fixation fixation-strength="1">睡眠<br-fixation fixation-strength="2">障碍<br-fixation fixation-strength="3">和躯<br-fixation fixation-strength="4">体化<br-edge>症状等。<br-bold><br-fixation fixation-strength="1">功能磁共振成像<br-fixation fixation-strength="2">技术从脑微观结<br-fixation fixation-strength="3">构及内在功能对<br-fixation fixation-strength="4">针刺治疗抑郁<br-edge>症的疗效进行多角度评价,<br-bold><br-fixation fixation-strength="1">体现出多模<br-fixation fixation-strength="2">态磁共振成<br-fixation fixation-strength="3">像技术在针<br-fixation fixation-strength="4">刺中枢机<br-edge>制研究方面的优势。<br-bold><br-fixation fixation-strength="1">但针刺<br-fixation fixation-strength="2">治疗抑<br-fixation fixation-strength="3">郁症磁<br-fixation fixation-strength="4">共振研<br-edge>究仍属少数,<br-bold><br-fixation fixation-strength="1">且多数采用<br-fixation fixation-strength="2">单一成像方<br-fixation fixation-strength="3">法选取结构<br-fixation fixation-strength="4">或功能等<br-edge>某个方面进行探讨,<br-bold><br-fixation fixation-strength="1">仅通过结构或<br-fixation fixation-strength="2">者功能角度均<br-fixation fixation-strength="3">不能见到脑活<br-fixation fixation-strength="4">动的全貌<br-edge>及磁共振多模态的优势。<br-bold><br-fixation fixation-strength="1">因<br-fixation fixation-strength="2">此,<br-bold><br-fixation fixation-strength="1">运用多模态<br-fixation fixation-strength="2">研究模式对<br-fixation fixation-strength="3">于从多个途<br-fixation fixation-strength="4">径研究<br-edge>针刺抗抑郁机制、<br-bold><br-fixation fixation-strength="1">结构和功<br-fixation fixation-strength="2">能变化间<br-fixation fixation-strength="3">的相互关<br-fixation fixation-strength="4">系<br-edge>具有重大意义,<br-bold><br-fixation fixation-strength="1">能够全面<br-fixation fixation-strength="2">的评价针<br-fixation fixation-strength="3">刺疗效及<br-fixation fixation-strength="4">分<br-edge>析其中枢机制。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7104921484
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 4
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">国家<br-fixation fixation-strength="2">自然<br-fixation fixation-strength="3">科学<br-fixation fixation-strength="4">基金<br-edge>面上项目(82074537,81973930,81373714)；<br-bold><br-fixation fixation-strength="1">黑龙<br-fixation fixation-strength="2">江省<br-fixation fixation-strength="3">自然<br-fixation fixation-strength="4">科学<br-edge>基金项目(<br-bold><br-fixation fixation-strength="1">L<br-fixation fixation-strength="2">H2020<br-bold><br-fixation fixation-strength="1">H103,<br-bold><br-fixation fixation-strength="1">H2016081)；<br-bold><br-fixation fixation-strength="1">哈尔滨市<br-fixation fixation-strength="2">科技创新<br-fixation fixation-strength="3">人才优秀<br-fixation fixation-strength="4">学<br-edge>科带头人基金(2016<br-bold><br-fixation fixation-strength="1">R<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">X<br-fixation fixation-strength="4">Y<br-edge>J096)；<br-bold><br-fixation fixation-strength="1">教<br-fixation fixation-strength="2">育<br-fixation fixation-strength="3">部“<br-bold><br-fixation fixation-strength="1">春<br-fixation fixation-strength="2">晖<br-fixation fixation-strength="3">计<br-edge>划”(<br-bold><br-fixation fixation-strength="1">Z2009-1-15030)；<br-bold><br-fixation fixation-strength="1">哈尔滨<br-fixation fixation-strength="2">市科技<br-fixation fixation-strength="3">创新人<br-fixation fixation-strength="4">才专<br-edge>项资金项目(2017<br-bold><br-fixation fixation-strength="1">R<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">Q<br-fixation fixation-strength="4">X<br-edge>J180)；<br-bold><br-fixation fixation-strength="1">黑龙<br-fixation fixation-strength="2">江省<br-fixation fixation-strength="3">中医<br-fixation fixation-strength="4">药科<br-edge>研项目(<br-bold><br-fixation fixation-strength="1">Z<br-fixation fixation-strength="2">H<br-fixation fixation-strength="3">Y12-<br-bold><br-fixation fixation-strength="1">Z046)；<br-bold><br-fixation fixation-strength="1">黑龙<br-fixation fixation-strength="2">江省<br-fixation fixation-strength="3">卫生<br-fixation fixation-strength="4">厅科<br-edge>研课题(2012-346)；<br-bold><br-fixation fixation-strength="1">黑龙江<br-fixation fixation-strength="2">中医药<br-fixation fixation-strength="3">大学研<br-fixation fixation-strength="4">究生创<br-edge>新科研项目(2020<br-bold><br-fixation fixation-strength="1">y<br-fixation fixation-strength="2">j<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">c<br-edge>x006)。



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">温振运气方<br-fixation fixation-strength="2">对慢性疲劳<br-fixation fixation-strength="3">综合征气虚<br-fixation fixation-strength="4">证患者脑功<br-edge>能和脑代谢的影响
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">黄<br-fixation fixation-strength="2">瑶
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">张<br-fixation fixation-strength="2">振<br-fixation fixation-strength="3">贤
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">李<br-fixation fixation-strength="2">冠<br-fixation fixation-strength="3">武
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">陈<br-fixation fixation-strength="2">畅
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">史<br-fixation fixation-strength="2">佳<br-fixation fixation-strength="3">宁
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">陈<br-fixation fixation-strength="2">敏
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">张<br-fixation fixation-strength="2">维<br-fixation fixation-strength="3">佳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">上海中医<br-fixation fixation-strength="2">药大学附<br-fixation fixation-strength="3">属岳阳中<br-fixation fixation-strength="4">西<br-edge>医结合医院,<br-bold><br-fixation fixation-strength="1">上<br-fixation fixation-strength="2">海<br-fixation fixation-strength="3">市200437
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1001-1668
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">中<br-fixation fixation-strength="2">医<br-fixation fixation-strength="3">杂<br-edge>志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2022
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 63
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 10
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 943-950
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">慢性<br-fixation fixation-strength="2">疲劳<br-fixation fixation-strength="3">综<br-fixation fixation-strength="4"><br-edge>合征
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">气<br-fixation fixation-strength="2">虚<br-fixation fixation-strength="3">证
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">温<br-fixation fixation-strength="2">振<br-fixation fixation-strength="3">运<br-fixation fixation-strength="4">气<br-edge>方
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">血氧<br-fixation fixation-strength="2">水平<br-fixation fixation-strength="3">依赖<br-fixation fixation-strength="4">功能<br-edge>磁共振
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">氢质<br-fixation fixation-strength="2">子磁<br-fixation fixation-strength="3">共振<br-fixation fixation-strength="4"><br-edge>波谱
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的观察温振运气<br-fixation fixation-strength="2">方干预慢性疲劳综<br-fixation fixation-strength="3">合征气虚证患者疲<br-fixation fixation-strength="4">劳及负性情绪的<br-edge>临床疗效并探索其中枢作用机制。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法60<br-bold><br-fixation fixation-strength="1">例慢性疲劳<br-fixation fixation-strength="2">综合征气虚<br-fixation fixation-strength="3">证患者随机<br-fixation fixation-strength="4">分为治<br-edge>疗组与对照组各30<br-bold><br-fixation fixation-strength="1">例,<br-bold><br-fixation fixation-strength="1">对照<br-fixation fixation-strength="2">组给<br-fixation fixation-strength="3">予基<br-fixation fixation-strength="4"><br-edge>础治疗,<br-bold><br-fixation fixation-strength="1">治疗组给<br-fixation fixation-strength="2">予基础治<br-fixation fixation-strength="3">疗联合温<br-fixation fixation-strength="4">振<br-edge>运气方口服,<br-bold><br-fixation fixation-strength="1">疗<br-fixation fixation-strength="2">程12<br-bold><br-fixation fixation-strength="1">周。<br-bold><br-fixation fixation-strength="1">于治<br-fixation fixation-strength="2">疗前<br-fixation fixation-strength="3">及<br-fixation fixation-strength="4"><br-edge>治疗6<br-bold><br-fixation fixation-strength="1">周、12<br-bold><br-fixation fixation-strength="1">周时测定<br-fixation fixation-strength="2">中医证候<br-fixation fixation-strength="3">量表评分<br-fixation fixation-strength="4">并判定<br-edge>中医证候疗效,<br-bold><br-fixation fixation-strength="1">治疗<br-fixation fixation-strength="2">前后<br-fixation fixation-strength="3">进行<br-fixation fixation-strength="4">疲<br-edge>劳量表(<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">S-14)<br-bold><br-fixation fixation-strength="1">评分<br-fixation fixation-strength="2">并判<br-fixation fixation-strength="3">定疲<br-fixation fixation-strength="4"><br-edge>劳疗效,<br-bold><br-fixation fixation-strength="1">治疗前<br-fixation fixation-strength="2">后采用<br-fixation fixation-strength="3">汉密顿<br-fixation fixation-strength="4"><br-edge>抑郁量表(<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">M<br-edge>D)<br-bold><br-fixation fixation-strength="1">与汉<br-fixation fixation-strength="2">密顿<br-fixation fixation-strength="3">焦虑<br-fixation fixation-strength="4"><br-edge>量表(<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">M<br-edge>A)<br-bold><br-fixation fixation-strength="1">评分<br-fixation fixation-strength="2">判定<br-fixation fixation-strength="3">负性<br-fixation fixation-strength="4">情<br-edge>绪情况,<br-bold><br-fixation fixation-strength="1">运用血<br-fixation fixation-strength="2">氧水平<br-fixation fixation-strength="3">依赖功<br-fixation fixation-strength="4"><br-edge>能磁共振(<br-bold><br-fixation fixation-strength="1">B<br-fixation fixation-strength="2">O<br-fixation fixation-strength="3">L<br-edge>D-<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-edge>I)、<br-bold><br-fixation fixation-strength="1">氢质<br-fixation fixation-strength="2">子磁<br-fixation fixation-strength="3">共振<br-fixation fixation-strength="4">波<br-edge>谱成像(1<br-bold><br-fixation fixation-strength="1">H-<br-bold><br-fixation fixation-strength="1">M<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">S)<br-bold><br-fixation fixation-strength="1">检测<br-fixation fixation-strength="2">治疗<br-fixation fixation-strength="3">前后<br-fixation fixation-strength="4">患者<br-edge>脑功能、<br-bold><br-fixation fixation-strength="1">脑<br-fixation fixation-strength="2">代<br-fixation fixation-strength="3">谢<br-fixation fixation-strength="4">变<br-edge>化。<br-bold><br-fixation fixation-strength="1">结果治<br-fixation fixation-strength="2">疗组中<br-fixation fixation-strength="3">医证候<br-fixation fixation-strength="4">疗效<br-edge>总有效率为90.00%,<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">S-14<br-bold><br-fixation fixation-strength="1">疗<br-fixation fixation-strength="2">效<br-fixation fixation-strength="3">总<br-fixation fixation-strength="4">有<br-edge>效率86.67%,<br-bold><br-fixation fixation-strength="1">对<br-fixation fixation-strength="2">照<br-fixation fixation-strength="3">组<br-fixation fixation-strength="4">分<br-edge>别为66.67%、60.00%,<br-bold><br-fixation fixation-strength="1">治疗<br-fixation fixation-strength="2">组均<br-fixation fixation-strength="3">优于<br-fixation fixation-strength="4"><br-edge>对照组(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">与本<br-fixation fixation-strength="2">组治<br-fixation fixation-strength="3">疗前<br-fixation fixation-strength="4"><br-edge>比较,<br-bold><br-fixation fixation-strength="1">治<br-fixation fixation-strength="2">疗<br-fixation fixation-strength="3">组<br-fixation fixation-strength="4">治<br-edge>疗6、12<br-bold><br-fixation fixation-strength="1">周时<br-fixation fixation-strength="2">中医<br-fixation fixation-strength="3">证候<br-fixation fixation-strength="4">总积<br-edge>分及神疲、<br-bold><br-fixation fixation-strength="1">气<br-fixation fixation-strength="2">短、<br-bold><br-fixation fixation-strength="1">乏力<br-fixation fixation-strength="2">症状<br-fixation fixation-strength="3">评分<br-fixation fixation-strength="4"><br-edge>降低,<br-bold><br-fixation fixation-strength="1">治<br-fixation fixation-strength="2">疗<br-fixation fixation-strength="3">后<br-fixation fixation-strength="4">F<br-edge>S-14<br-bold><br-fixation fixation-strength="1">总<br-fixation fixation-strength="2">分、<br-bold><br-fixation fixation-strength="1">躯体疲劳<br-fixation fixation-strength="2">评分与脑<br-fixation fixation-strength="3">力疲劳评<br-fixation fixation-strength="4">分均<br-edge>较治疗前降低,<br-bold><br-fixation fixation-strength="1">且均<br-fixation fixation-strength="2">显著<br-fixation fixation-strength="3">优于<br-fixation fixation-strength="4"><br-edge>对照组(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">或<br-fixation fixation-strength="2">P<br-fixation fixation-strength="1">治疗<br-fixation fixation-strength="2">后治<br-fixation fixation-strength="3">疗组<br-fixation fixation-strength="4">HA<br-edge>MD总分、<br-bold><br-fixation fixation-strength="1">焦<br-fixation fixation-strength="2">虑/<br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">化、<br-bold><br-fixation fixation-strength="1">日<br-fixation fixation-strength="2">夜<br-fixation fixation-strength="3">变<br-edge>化、<br-bold><br-fixation fixation-strength="1">睡<br-fixation fixation-strength="2">眠<br-fixation fixation-strength="3">障<br-edge>碍、<br-bold><br-fixation fixation-strength="1">绝<br-fixation fixation-strength="2">望<br-fixation fixation-strength="3">感、<br-bold><br-fixation fixation-strength="1">认知<br-fixation fixation-strength="2">障碍<br-fixation fixation-strength="3">及H<br-fixation fixation-strength="4">AM<br-edge>A总分、<br-bold><br-fixation fixation-strength="1">躯<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">性<br-fixation fixation-strength="4">焦<br-edge>虑、<br-bold><br-fixation fixation-strength="1">精神性<br-fixation fixation-strength="2">焦虑评<br-fixation fixation-strength="3">分均较<br-fixation fixation-strength="4">治疗<br-edge>前显著降低(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">或<br-fixation fixation-strength="2">P<br-fixation fixation-strength="1">治疗<br-fixation fixation-strength="2">组治<br-fixation fixation-strength="3">疗后<br-fixation fixation-strength="4">在双<br-edge>侧额中回、<br-bold><br-fixation fixation-strength="1">右侧<br-fixation fixation-strength="2">三角<br-fixation fixation-strength="3">部额<br-fixation fixation-strength="4"><br-edge>下回、<br-bold><br-fixation fixation-strength="1">左侧背<br-fixation fixation-strength="2">外侧额<br-fixation fixation-strength="3">上回均<br-fixation fixation-strength="4">出现<br-edge>低频振幅(<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">L<br-fixation fixation-strength="3">F<br-edge>F)<br-bold><br-fixation fixation-strength="1">与局<br-fixation fixation-strength="2">部一<br-fixation fixation-strength="3">致性<br-fixation fixation-strength="4"><br-edge>方法(<br-bold><br-fixation fixation-strength="1">R<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">H<br-edge>o)<br-bold><br-fixation fixation-strength="1">增<br-fixation fixation-strength="2">高,<br-bold><br-fixation fixation-strength="1">在<br-fixation fixation-strength="2">右<br-fixation fixation-strength="3">侧<br-fixation fixation-strength="4">梭<br-edge>状回、<br-bold><br-fixation fixation-strength="1">右侧楔<br-fixation fixation-strength="2">前叶出<br-fixation fixation-strength="3">现AL<br-fixation fixation-strength="4"><br-edge>FF降低(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">治疗<br-fixation fixation-strength="2">组双<br-fixation fixation-strength="3">侧额<br-fixation fixation-strength="4"><br-edge>中回N-<br-bold><br-fixation fixation-strength="1">乙酰<br-fixation fixation-strength="2">天门<br-fixation fixation-strength="3">冬<br-fixation fixation-strength="4"><br-edge>氨酸(<br-bold><br-fixation fixation-strength="1">N<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">A)/<br-bold><br-fixation fixation-strength="1">肌<br-fixation fixation-strength="2">酸(<br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">r)<br-bold><br-fixation fixation-strength="1">较<br-fixation fixation-strength="2">治<br-fixation fixation-strength="3">疗<br-fixation fixation-strength="4">前<br-edge>升高(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">且较<br-fixation fixation-strength="2">对照<br-fixation fixation-strength="3">组升<br-fixation fixation-strength="4">高<br-edge>更显著(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">结论温振运<br-fixation fixation-strength="2">气方可有效<br-fixation fixation-strength="3">改善慢性疲<br-fixation fixation-strength="4">劳综合征患<br-edge>者的中医临床症状,<br-bold><br-fixation fixation-strength="1">缓<br-fixation fixation-strength="2">解<br-fixation fixation-strength="3">疲<br-edge>劳,<br-bold><br-fixation fixation-strength="1">改<br-fixation fixation-strength="2">善<br-fixation fixation-strength="3">抑<br-edge>郁、<br-bold><br-fixation fixation-strength="1">焦<br-fixation fixation-strength="2">虑<br-fixation fixation-strength="3">状<br-edge>态,<br-bold><br-fixation fixation-strength="1">其机制可能与提<br-fixation fixation-strength="2">高前额叶部分脑<br-fixation fixation-strength="3">区神经活动及调<br-fixation fixation-strength="4">节双侧额<br-edge>中回NAA脑代谢相关。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7107418702
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 12
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">国家<br-fixation fixation-strength="2">自然<br-fixation fixation-strength="3">科学<br-fixation fixation-strength="4"><br-edge>基金(81373624)；<br-bold><br-fixation fixation-strength="1">上海市<br-fixation fixation-strength="2">中医药<br-fixation fixation-strength="3">事业发<br-fixation fixation-strength="4">展三<br-edge>年行动计划[<br-bold><br-fixation fixation-strength="1">Z<br-fixation fixation-strength="2">Y(2018-2020)-<br-bold><br-fixation fixation-strength="1">Z<br-fixation fixation-strength="2">W<br-fixation fixation-strength="3">B-1001]。



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">莱茵衣<br-fixation fixation-strength="2">藻BB<br-fixation fixation-strength="3">Som<br-fixation fixation-strength="4">e蛋<br-edge>白BBS2<br-bold><br-fixation fixation-strength="1">原<br-fixation fixation-strength="2">核<br-fixation fixation-strength="3">表<br-edge>达、<br-bold><br-fixation fixation-strength="1">纯化和<br-fixation fixation-strength="2">多克隆<br-fixation fixation-strength="3">抗体的<br-fixation fixation-strength="4">制<br-edge>备及鉴定
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">董<br-fixation fixation-strength="2">彬
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">吴<br-fixation fixation-strength="2">松
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">程<br-fixation fixation-strength="2">荣<br-fixation fixation-strength="3">强
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">孟<br-fixation fixation-strength="2">德<br-fixation fixation-strength="3">梅
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">樊<br-fixation fixation-strength="2">振<br-fixation fixation-strength="3">川
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">天津科技大学<br-fixation fixation-strength="2">食品工程与生<br-fixation fixation-strength="3">物技术学院教<br-fixation fixation-strength="4">育部食品<br-edge>营养与安全重点实验室,<br-bold><br-fixation fixation-strength="1">天<br-fixation fixation-strength="2">津300457
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">天津科<br-fixation fixation-strength="2">技大学<br-fixation fixation-strength="3">新农村<br-fixation fixation-strength="4">发<br-edge>展研究院,<br-bold><br-fixation fixation-strength="1">天<br-fixation fixation-strength="2">津300457
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1673-1689
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">食品<br-fixation fixation-strength="2">与生<br-fixation fixation-strength="3">物技<br-fixation fixation-strength="4"><br-edge>术学报
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2019
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 38
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 2
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 145-152
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">莱<br-fixation fixation-strength="2">茵<br-fixation fixation-strength="3">衣<br-edge>藻
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">纤<br-fixation fixation-strength="2">毛
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">B<br-fixation fixation-strength="2">B<br-fixation fixation-strength="3">S2
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">原<br-fixation fixation-strength="2">核<br-fixation fixation-strength="3">表<br-edge>达
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">蛋<br-fixation fixation-strength="2">白<br-fixation fixation-strength="3">纯<br-edge>化
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">多<br-fixation fixation-strength="2">克<br-fixation fixation-strength="3">隆<br-fixation fixation-strength="4">抗<br-edge>体
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">BBSo<br-fixation fixation-strength="2">me蛋白<br-fixation fixation-strength="3">复合物是<br-fixation fixation-strength="4">纤毛<br-edge>蛋白组分之一,<br-bold><br-fixation fixation-strength="1">BBSo<br-fixation fixation-strength="2">me组装<br-fixation fixation-strength="3">或纤毛运<br-fixation fixation-strength="4">输<br-edge>缺陷可导致巴-<br-bold><br-fixation fixation-strength="1">比<br-fixation fixation-strength="2">二<br-fixation fixation-strength="3">氏<br-fixation fixation-strength="4">综<br-edge>合征。<br-bold><br-fixation fixation-strength="1">其<br-fixation fixation-strength="2">中,<br-bold><br-fixation fixation-strength="1">BB<br-fixation fixation-strength="2">So<br-fixation fixation-strength="3">me<br-fixation fixation-strength="4">组分<br-edge>BBS2<br-bold><br-fixation fixation-strength="1">缺失已被<br-fixation fixation-strength="2">临床证明<br-fixation fixation-strength="3">是导致B<br-fixation fixation-strength="4">B<br-edge>S的病因之一。<br-bold><br-fixation fixation-strength="1">莱茵衣藻是研<br-fixation fixation-strength="2">究BBSom<br-fixation fixation-strength="3">e组装和纤毛<br-fixation fixation-strength="4">运输的<br-edge>一种很好的模式生物。<br-bold><br-fixation fixation-strength="1">为深<br-fixation fixation-strength="2">入研<br-fixation fixation-strength="3">究B<br-fixation fixation-strength="4"><br-edge>BS2<br-bold><br-fixation fixation-strength="1">的<br-fixation fixation-strength="2">致<br-fixation fixation-strength="3">病<br-fixation fixation-strength="4">机<br-edge>制,<br-bold><br-fixation fixation-strength="1">需要<br-fixation fixation-strength="2">特异<br-fixation fixation-strength="3">性识<br-fixation fixation-strength="4">别其<br-edge>BBS2<br-bold><br-fixation fixation-strength="1">蛋<br-fixation fixation-strength="2">白<br-fixation fixation-strength="3">的<br-fixation fixation-strength="4">抗<br-edge>体。<br-bold><br-fixation fixation-strength="1">本文<br-fixation fixation-strength="2">将莱<br-fixation fixation-strength="3">茵衣<br-fixation fixation-strength="4">藻<br-edge>BBS2<br-bold><br-fixation fixation-strength="1">基<br-fixation fixation-strength="2">因5’<br-bold><br-fixation fixation-strength="1">端399 <br-bold><br-fixation fixation-strength="1">bp的c<br-fixation fixation-strength="2">DNA序<br-fixation fixation-strength="3">列克隆到<br-fixation fixation-strength="4">原核表<br-edge>达载体pET28<br-bold><br-fixation fixation-strength="1">a-<br-bold><br-fixation fixation-strength="1">b<br-fixation fixation-strength="2">b<br-fixation fixation-strength="3">s2,<br-bold><br-fixation fixation-strength="1">转入<br-fixation fixation-strength="2">大肠<br-fixation fixation-strength="3">杆菌<br-fixation fixation-strength="4"><br-edge>BL21(<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">E3)<br-bold><br-fixation fixation-strength="1">细胞<br-fixation fixation-strength="2">进行<br-fixation fixation-strength="3">诱导<br-fixation fixation-strength="4"><br-edge>表达。<br-bold><br-fixation fixation-strength="1">在8 <br-bold><br-fixation fixation-strength="1">m<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l/<br-bold><br-fixation fixation-strength="1">L尿素存<br-fixation fixation-strength="2">在的情况<br-fixation fixation-strength="3">下对该融<br-fixation fixation-strength="4">合蛋白进<br-edge>行镍柱亲和纯化,<br-bold><br-fixation fixation-strength="1">并将纯化<br-fixation fixation-strength="2">后的融合<br-fixation fixation-strength="3">蛋白免疫<br-fixation fixation-strength="4">新<br-edge>西兰大白兔。<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">S-<br-bold><br-fixation fixation-strength="1">PA<br-fixation fixation-strength="2">GE<br-fixation fixation-strength="3">电泳<br-fixation fixation-strength="4">结<br-edge>果表明:<br-bold><br-fixation fixation-strength="1">分<br-fixation fixation-strength="2">子<br-fixation fixation-strength="3">量<br-edge>为15 <br-bold><br-fixation fixation-strength="1">k<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">a<br-fixation fixation-strength="4">的<br-edge>重组6×<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">s-<br-bold><br-fixation fixation-strength="1">B<br-fixation fixation-strength="2">B<br-fixation fixation-strength="3">S2<br-bold><br-fixation fixation-strength="1">融合<br-fixation fixation-strength="2">蛋白<br-fixation fixation-strength="3">为水<br-fixation fixation-strength="4">不溶<br-edge>性蛋白。5<br-bold><br-fixation fixation-strength="1">次免疫<br-fixation fixation-strength="2">后的抗<br-fixation fixation-strength="3">莱茵衣<br-fixation fixation-strength="4"><br-edge>藻BBS2<br-bold><br-fixation fixation-strength="1">抗血<br-fixation fixation-strength="2">清效<br-fixation fixation-strength="3">价<br-fixation fixation-strength="4"><br-edge>高达1∶256 000。<br-bold><br-fixation fixation-strength="1">经P<br-fixation fixation-strength="2">ro<br-fixation fixation-strength="3">te<br-fixation fixation-strength="4"><br-edge>in <br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">琼<br-fixation fixation-strength="3">脂<br-fixation fixation-strength="4">糖<br-edge>CL-4<br-bold><br-fixation fixation-strength="1">B亲和纯<br-fixation fixation-strength="2">化后的抗<br-fixation fixation-strength="3">血清不仅<br-fixation fixation-strength="4">在W<br-edge>estern <br-bold><br-fixation fixation-strength="1">blott<br-fixation fixation-strength="2">ing分析<br-fixation fixation-strength="3">中能特异性<br-fixation fixation-strength="4">识别<br-edge>莱茵衣藻BBS2,<br-bold><br-fixation fixation-strength="1">而且在免<br-fixation fixation-strength="2">疫荧光染<br-fixation fixation-strength="3">色分析中<br-fixation fixation-strength="4">能精<br-edge>确定位BBS2<br-bold><br-fixation fixation-strength="1">于基<br-fixation fixation-strength="2">体和<br-fixation fixation-strength="3">纤<br-fixation fixation-strength="4"><br-edge>毛内。<br-bold><br-fixation fixation-strength="1">这一多克<br-fixation fixation-strength="2">隆抗体的<br-fixation fixation-strength="3">成功制备<br-fixation fixation-strength="4">为深<br-edge>入开展BBS2<br-bold><br-fixation fixation-strength="1">在BBSo<br-fixation fixation-strength="2">me组装和<br-fixation fixation-strength="3">纤毛运输中<br-fixation fixation-strength="4">的分子作<br-edge>用机制提供了基础。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7001761880
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 1
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">天津市<br-fixation fixation-strength="2">应用基<br-fixation fixation-strength="3">础与前<br-fixation fixation-strength="4">沿技<br-edge>术研究计划(13<br-bold><br-fixation fixation-strength="1">J<br-fixation fixation-strength="2">C<br-fixation fixation-strength="3">Y<br-fixation fixation-strength="4">B<br-edge>JC41900)；<br-bold><br-fixation fixation-strength="1">天津科<br-fixation fixation-strength="2">技大学<br-fixation fixation-strength="3">引进人<br-fixation fixation-strength="4">才科<br-edge>研启动费(20130420)



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">家族性<br-fixation fixation-strength="2">致死性<br-fixation fixation-strength="3">失眠症<br-fixation fixation-strength="4"><br-edge>诊断标准
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">靖<br-fixation fixation-strength="2">冬<br-fixation fixation-strength="3">来
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">陆<br-fixation fixation-strength="2">慧
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">黄<br-fixation fixation-strength="2">朝<br-fixation fixation-strength="3">阳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">周<br-fixation fixation-strength="2">爱<br-fixation fixation-strength="3">红
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">左<br-fixation fixation-strength="2">秀<br-fixation fixation-strength="3">美
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">高<br-fixation fixation-strength="2">冉
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">崔<br-fixation fixation-strength="2">玥
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">孔<br-fixation fixation-strength="2">雨
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">武<br-fixation fixation-strength="2">力<br-fixation fixation-strength="3">勇
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">首都医<br-fixation fixation-strength="2">科大学<br-fixation fixation-strength="3">宣武医<br-fixation fixation-strength="4">院<br-edge>神经内科
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1000-3002
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">中国<br-fixation fixation-strength="2">药理<br-fixation fixation-strength="3">学与<br-fixation fixation-strength="4">毒理<br-edge>学杂志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2019
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 33
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 6
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 438-439
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">痴<br-fixation fixation-strength="2">呆
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">失<br-fixation fixation-strength="2">眠
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">家<br-fixation fixation-strength="2">族<br-fixation fixation-strength="3">性<br-fixation fixation-strength="4">失<br-edge>眠症
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">睡<br-fixation fixation-strength="2">眠<br-fixation fixation-strength="3">多<br-fixation fixation-strength="4">导<br-edge>图
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">N<br-fixation fixation-strength="4">P<br-edge>基因
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的<br-fixation fixation-strength="2">家族<br-fixation fixation-strength="3">性致<br-fixation fixation-strength="4">死性<br-edge>失眠症(<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">F<br-fixation fixation-strength="3">I)<br-bold><br-fixation fixation-strength="1">是一种罕<br-fixation fixation-strength="2">见的常染<br-fixation fixation-strength="3">色体显性<br-fixation fixation-strength="4">遗传致<br-edge>死性朊蛋白病,<br-bold><br-fixation fixation-strength="1">临床<br-fixation fixation-strength="2">主要<br-fixation fixation-strength="3">表现<br-fixation fixation-strength="4">为睡<br-edge>眠障碍、<br-bold><br-fixation fixation-strength="1">快速<br-fixation fixation-strength="2">进展<br-fixation fixation-strength="3">性<br-fixation fixation-strength="4"><br-edge>痴呆、<br-bold><br-fixation fixation-strength="1">自主<br-fixation fixation-strength="2">神经<br-fixation fixation-strength="3">功能<br-fixation fixation-strength="4"><br-edge>损害等。<br-bold><br-fixation fixation-strength="1">由于该病<br-fixation fixation-strength="2">罕见且其<br-fixation fixation-strength="3">临床症状<br-fixation fixation-strength="4">的异质<br-edge>性和非特异性,<br-bold><br-fixation fixation-strength="1">临床医<br-fixation fixation-strength="2">生对其<br-fixation fixation-strength="3">早期临<br-fixation fixation-strength="4">床识<br-edge>别较为困难,<br-bold><br-fixation fixation-strength="1">容易<br-fixation fixation-strength="2">造成<br-fixation fixation-strength="3">误诊<br-fixation fixation-strength="4"><br-edge>及漏诊。<br-bold><br-fixation fixation-strength="1">本<br-fixation fixation-strength="2">研<br-fixation fixation-strength="3">究<br-fixation fixation-strength="4">总<br-edge>结了10<br-bold><br-fixation fixation-strength="1">例FFI<br-fixation fixation-strength="2">患者的的<br-fixation fixation-strength="3">临床特征<br-fixation fixation-strength="4">及<br-edge>辅助检查特点,<br-bold><br-fixation fixation-strength="1">提出了适<br-fixation fixation-strength="2">合中国人<br-fixation fixation-strength="3">群的FF<br-fixation fixation-strength="4">I<br-edge>的诊断标准。<br-bold><br-fixation fixation-strength="1">方法<br-fixation fixation-strength="2">回顾<br-fixation fixation-strength="3">性总<br-fixation fixation-strength="4"><br-edge>结分析2009<br-bold><br-fixation fixation-strength="1">年<br-fixation fixation-strength="2">至2018<br-bold><br-fixation fixation-strength="1">年期间首都<br-fixation fixation-strength="2">医科大学宣<br-fixation fixation-strength="3">武医院神经<br-fixation fixation-strength="4">内科收治的<br-edge>经过基因检查确诊的10<br-bold><br-fixation fixation-strength="1">例F<br-fixation fixation-strength="2">FI<br-fixation fixation-strength="3">患者<br-fixation fixation-strength="4">的临<br-edge>床表现、<br-bold><br-fixation fixation-strength="1">神经<br-fixation fixation-strength="2">心理<br-fixation fixation-strength="3">学<br-fixation fixation-strength="4"><br-edge>检查、<br-bold><br-fixation fixation-strength="1">脑<br-fixation fixation-strength="2">脊<br-fixation fixation-strength="3">液<br-fixation fixation-strength="4">检<br-edge>查、<br-bold><br-fixation fixation-strength="1">多<br-fixation fixation-strength="2">导<br-fixation fixation-strength="3">睡<br-fixation fixation-strength="4">眠<br-edge>图(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">G)、<br-bold><br-fixation fixation-strength="1">头<br-fixation fixation-strength="2">颅<br-fixation fixation-strength="3">M<br-fixation fixation-strength="4">R<br-edge>I、<br-bold><br-fixation fixation-strength="1">头<br-fixation fixation-strength="2">颅[18<br-bold><br-fixation fixation-strength="1">F]<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">G <br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">E<br-fixation fixation-strength="3">T、<br-bold><br-fixation fixation-strength="1">脑<br-fixation fixation-strength="2">血<br-fixation fixation-strength="3">流<br-fixation fixation-strength="4">灌<br-edge>注、<br-bold><br-fixation fixation-strength="1">脑<br-fixation fixation-strength="2">电<br-fixation fixation-strength="3">图<br-fixation fixation-strength="4">等<br-edge>资料,<br-bold><br-fixation fixation-strength="1">并结<br-fixation fixation-strength="2">合文<br-fixation fixation-strength="3">献进<br-fixation fixation-strength="4"><br-edge>行复习。<br-bold><br-fixation fixation-strength="1">结<br-fixation fixation-strength="2">果 (1)<br-bold><br-fixation fixation-strength="1">本研<br-fixation fixation-strength="2">究共<br-fixation fixation-strength="3">收<br-fixation fixation-strength="4"><br-edge>集了10<br-bold><br-fixation fixation-strength="1">例中<br-fixation fixation-strength="2">国汉<br-fixation fixation-strength="3">族<br-fixation fixation-strength="4"><br-edge>患者(<br-bold><br-fixation fixation-strength="1">男5<br-bold><br-fixation fixation-strength="1">例,<br-bold><br-fixation fixation-strength="1">女5<br-bold><br-fixation fixation-strength="1">例)。<br-bold><br-fixation fixation-strength="1">FF<br-fixation fixation-strength="2">I起<br-fixation fixation-strength="3">病年<br-fixation fixation-strength="4">龄平<br-edge>均年龄为50.9<br-bold><br-fixation fixation-strength="1">岁(19~64<br-bold><br-fixation fixation-strength="1">岁)。<br-bold><br-fixation fixation-strength="1">所<br-fixation fixation-strength="2">有10<br-bold><br-fixation fixation-strength="1">例患者<br-fixation fixation-strength="2">最突出<br-fixation fixation-strength="3">的临床<br-fixation fixation-strength="4">表现<br-edge>为睡眠障碍,<br-bold><br-fixation fixation-strength="1">包<br-fixation fixation-strength="2">括<br-fixation fixation-strength="3">失<br-edge>眠、<br-bold><br-fixation fixation-strength="1">喉<br-fixation fixation-strength="2">鸣、<br-bold><br-fixation fixation-strength="1">睡眠<br-fixation fixation-strength="2">相关<br-fixation fixation-strength="3">的呼<br-fixation fixation-strength="4"><br-edge>吸障碍、<br-bold><br-fixation fixation-strength="1">以及与<br-fixation fixation-strength="2">睡眠相<br-fixation fixation-strength="3">关的非<br-fixation fixation-strength="4"><br-edge>自主运动。<br-bold><br-fixation fixation-strength="1">所有患者<br-fixation fixation-strength="2">都伴有快<br-fixation fixation-strength="3">速进展性<br-fixation fixation-strength="4">痴<br-edge>呆和精神症状。<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例1<br-bold><br-fixation fixation-strength="1">和<br-fixation fixation-strength="2">病<br-fixation fixation-strength="3">例2<br-bold><br-fixation fixation-strength="1">的M<br-fixation fixation-strength="2">MS<br-fixation fixation-strength="3">E评<br-fixation fixation-strength="4"><br-edge>分仅为4<br-bold><br-fixation fixation-strength="1">分,<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例2<br-bold><br-fixation fixation-strength="1">的<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">o <br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">评<br-fixation fixation-strength="4">分<br-edge>为0<br-bold><br-fixation fixation-strength="1">分,<br-bold><br-fixation fixation-strength="1">临床<br-fixation fixation-strength="2">痴呆<br-fixation fixation-strength="3">评<br-fixation fixation-strength="4"><br-edge>分为3<br-bold><br-fixation fixation-strength="1">分,<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例5<br-bold><br-fixation fixation-strength="1">的临<br-fixation fixation-strength="2">床痴<br-fixation fixation-strength="3">呆评<br-fixation fixation-strength="4"><br-edge>分为2<br-bold><br-fixation fixation-strength="1">分,<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例6<br-bold><br-fixation fixation-strength="1">的M<br-fixation fixation-strength="2">MS<br-fixation fixation-strength="3">E评<br-fixation fixation-strength="4"><br-edge>分为14<br-bold><br-fixation fixation-strength="1">分,<br-bold><br-fixation fixation-strength="1">M<br-fixation fixation-strength="2">o <br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">评<br-fixation fixation-strength="4">分<br-edge>为8<br-bold><br-fixation fixation-strength="1">分,<br-bold><br-fixation fixation-strength="1">临床<br-fixation fixation-strength="2">痴呆<br-fixation fixation-strength="3">评<br-fixation fixation-strength="4"><br-edge>分为2<br-bold><br-fixation fixation-strength="1">分。<br-bold><br-fixation fixation-strength="1">其他<br-fixation fixation-strength="2">患者<br-fixation fixation-strength="3">因严<br-fixation fixation-strength="4">重<br-edge>的痴呆,<br-bold><br-fixation fixation-strength="1">不能<br-fixation fixation-strength="2">完成<br-fixation fixation-strength="3">认知<br-fixation fixation-strength="4"><br-edge>量表。<br-bold><br-fixation fixation-strength="1">所有患者同<br-fixation fixation-strength="2">时也表现出<br-fixation fixation-strength="3">不同组合的<br-fixation fixation-strength="4">进行<br-edge>性自主神经损害,<br-bold><br-fixation fixation-strength="1">如<br-fixation fixation-strength="2">高<br-fixation fixation-strength="3">血<br-edge>压、<br-bold><br-fixation fixation-strength="1">出<br-fixation fixation-strength="2">汗、<br-bold><br-fixation fixation-strength="1">心动<br-fixation fixation-strength="2">过速<br-fixation fixation-strength="3">和呼<br-fixation fixation-strength="4">吸不<br-edge>规则等；<br-bold><br-fixation fixation-strength="1">伴或<br-fixation fixation-strength="2">不伴<br-fixation fixation-strength="3">有共<br-fixation fixation-strength="4"><br-edge>济失调、<br-bold><br-fixation fixation-strength="1">锥<br-fixation fixation-strength="2">体<br-fixation fixation-strength="3">束<br-edge>征、<br-bold><br-fixation fixation-strength="1">锥体<br-fixation fixation-strength="2">外系<br-fixation fixation-strength="3">征和<br-fixation fixation-strength="4">构<br-edge>音障碍。(2)<br-bold><br-fixation fixation-strength="1">所有<br-fixation fixation-strength="2">患者<br-fixation fixation-strength="3">基因<br-fixation fixation-strength="4">检<br-edge>查显示,20<br-bold><br-fixation fixation-strength="1">号染色<br-fixation fixation-strength="2">体PR<br-fixation fixation-strength="3">NP基<br-fixation fixation-strength="4"><br-edge>因出现D178<br-bold><br-fixation fixation-strength="1">N<br-fixation fixation-strength="2">突<br-fixation fixation-strength="3">变,129<br-bold><br-fixation fixation-strength="1">位<br-fixation fixation-strength="2">氨<br-fixation fixation-strength="3">基<br-fixation fixation-strength="4">酸<br-edge>为M/<br-bold><br-fixation fixation-strength="1">M<br-fixation fixation-strength="2">型；<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例1<br-bold><br-fixation fixation-strength="1">和<br-fixation fixation-strength="2">病<br-fixation fixation-strength="3">例2<br-bold><br-fixation fixation-strength="1">是<br-fixation fixation-strength="2">兄<br-fixation fixation-strength="3">妹,<br-bold><br-fixation fixation-strength="1">经调查他<br-fixation fixation-strength="2">们的母亲<br-fixation fixation-strength="3">和哥哥有<br-fixation fixation-strength="4">类似<br-edge>的FFI症状。<br-bold><br-fixation fixation-strength="1">对其家<br-fixation fixation-strength="2">庭成员<br-fixation fixation-strength="3">进行给<br-fixation fixation-strength="4">基因检<br-edge>查提示病例1<br-bold><br-fixation fixation-strength="1">的外甥<br-fixation fixation-strength="2">和侄子<br-fixation fixation-strength="3">为身体<br-fixation fixation-strength="4">健康的<br-edge>基因携带者。<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例5<br-bold><br-fixation fixation-strength="1">的母亲<br-fixation fixation-strength="2">因快速<br-fixation fixation-strength="3">进展性<br-fixation fixation-strength="4">痴<br-edge>呆而死亡,<br-bold><br-fixation fixation-strength="1">享<br-fixation fixation-strength="2">年70<br-bold><br-fixation fixation-strength="1">岁。<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例6<br-bold><br-fixation fixation-strength="1">的父<br-fixation fixation-strength="2">亲因<br-fixation fixation-strength="3">出现<br-fixation fixation-strength="4">精<br-edge>神异常、<br-bold><br-fixation fixation-strength="1">嗜<br-fixation fixation-strength="2">睡<br-fixation fixation-strength="3">症<br-edge>状1<br-bold><br-fixation fixation-strength="1">年<br-fixation fixation-strength="2">内<br-fixation fixation-strength="3">死<br-edge>亡。<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例7<br-bold><br-fixation fixation-strength="1">的妹妹<br-fixation fixation-strength="2">和侄子<br-fixation fixation-strength="3">均有类<br-fixation fixation-strength="4">似F<br-edge>FI的症状。<br-bold><br-fixation fixation-strength="1">经家<br-fixation fixation-strength="2">系调<br-fixation fixation-strength="3">查<br-fixation fixation-strength="4"><br-edge>病例10<br-bold><br-fixation fixation-strength="1">的<br-fixation fixation-strength="2">姑<br-fixation fixation-strength="3">姑、<br-bold><br-fixation fixation-strength="1">大哥以<br-fixation fixation-strength="2">及两个<br-fixation fixation-strength="3">表兄均<br-fixation fixation-strength="4">有类<br-edge>似的症状,<br-bold><br-fixation fixation-strength="1">对其家庭<br-fixation fixation-strength="2">成员进行<br-fixation fixation-strength="3">给基因检<br-fixation fixation-strength="4">查<br-edge>患者的弟弟、<br-bold><br-fixation fixation-strength="1">侄女均<br-fixation fixation-strength="2">为身体<br-fixation fixation-strength="3">健康的<br-fixation fixation-strength="4">基<br-edge>因携带者。<br-bold><br-fixation fixation-strength="1">另<br-fixation fixation-strength="2">外<br-fixation fixation-strength="3">五<br-fixation fixation-strength="4">位<br-edge>患者(<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例3,4,6,8,9)<br-bold><br-fixation fixation-strength="1">没<br-fixation fixation-strength="2">有<br-fixation fixation-strength="3">家<br-fixation fixation-strength="4">族<br-edge>史。(3)<br-bold><br-fixation fixation-strength="1">腰椎<br-fixation fixation-strength="2">穿刺<br-fixation fixation-strength="3">检查<br-fixation fixation-strength="4">提<br-edge>示病例8 <br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">F14-3-3<br-bold><br-fixation fixation-strength="1">蛋<br-fixation fixation-strength="2">白<br-fixation fixation-strength="3">阳<br-edge>性,<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例7,9<br-bold><br-fixation fixation-strength="1">未<br-fixation fixation-strength="2">查<br-fixation fixation-strength="3">C<br-fixation fixation-strength="4">S<br-edge>F14-3-3<br-bold><br-fixation fixation-strength="1">蛋<br-fixation fixation-strength="2">白,<br-bold><br-fixation fixation-strength="1">其他<br-fixation fixation-strength="2">患者<br-fixation fixation-strength="3">C<br-fixation fixation-strength="4"><br-edge>SF14-3-3<br-bold><br-fixation fixation-strength="1">蛋<br-fixation fixation-strength="2">白<br-fixation fixation-strength="3">均<br-fixation fixation-strength="4">为<br-edge>阴性。<br-bold><br-fixation fixation-strength="1">EE<br-fixation fixation-strength="2">G显<br-fixation fixation-strength="3">示弥<br-fixation fixation-strength="4">散<br-edge>性慢波,<br-bold><br-fixation fixation-strength="1">无周<br-fixation fixation-strength="2">期性<br-fixation fixation-strength="3">尖峰<br-fixation fixation-strength="4"><br-edge>放电。<br-bold><br-fixation fixation-strength="1">脑M<br-fixation fixation-strength="2">RI<br-fixation fixation-strength="3">未提<br-fixation fixation-strength="4">示特<br-edge>征性改变。<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例1 <br-bold><br-fixation fixation-strength="1">SP<br-fixation fixation-strength="2">EC<br-fixation fixation-strength="3">T提<br-fixation fixation-strength="4">示双<br-edge>侧丘脑、<br-bold><br-fixation fixation-strength="1">基<br-fixation fixation-strength="2">底<br-fixation fixation-strength="3">节、<br-bold><br-fixation fixation-strength="1">内侧<br-fixation fixation-strength="2">颞叶<br-fixation fixation-strength="3">血流<br-fixation fixation-strength="4">灌<br-edge>注下降。<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例2[18<br-bold><br-fixation fixation-strength="1">F]<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">G <br-bold><br-fixation fixation-strength="1">PET显<br-fixation fixation-strength="2">示左丘脑<br-fixation fixation-strength="3">和双侧下<br-fixation fixation-strength="4">顶叶的<br-edge>葡萄糖摄取减低。<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例7[18<br-bold><br-fixation fixation-strength="1">F]<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">G <br-bold><br-fixation fixation-strength="1">PET<br-fixation fixation-strength="2">显示额<br-fixation fixation-strength="3">颞叶葡<br-fixation fixation-strength="4">萄糖代<br-edge>谢减低明显,<br-bold><br-fixation fixation-strength="1">下<br-fixation fixation-strength="2">顶<br-fixation fixation-strength="3">叶、<br-bold><br-fixation fixation-strength="1">左侧<br-fixation fixation-strength="2">丘脑<br-fixation fixation-strength="3">代谢<br-fixation fixation-strength="4"><br-edge>减低。<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例10[18<br-bold><br-fixation fixation-strength="1">F]<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">G <br-bold><br-fixation fixation-strength="1">PE<br-fixation fixation-strength="2">T显<br-fixation fixation-strength="3">示双<br-fixation fixation-strength="4">侧大<br-edge>脑皮层,<br-bold><br-fixation fixation-strength="1">尾<br-fixation fixation-strength="2">状<br-fixation fixation-strength="3">核<br-edge>头、<br-bold><br-fixation fixation-strength="1">丘脑<br-fixation fixation-strength="2">代谢<br-fixation fixation-strength="3">重度<br-fixation fixation-strength="4"><br-edge>减低。<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例1<br-bold><br-fixation fixation-strength="1">的MR<br-fixation fixation-strength="2">S分析<br-fixation fixation-strength="3">显示左<br-fixation fixation-strength="4"><br-edge>侧丘脑N-<br-bold><br-fixation fixation-strength="1">乙酰<br-fixation fixation-strength="2">天门<br-fixation fixation-strength="3">冬氨<br-fixation fixation-strength="4">酸水<br-edge>平下降(<br-bold><br-fixation fixation-strength="1">N<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">A)。(4) 9<br-bold><br-fixation fixation-strength="1">名<br-fixation fixation-strength="2">患<br-fixation fixation-strength="3">者(<br-bold><br-fixation fixation-strength="1">病<br-fixation fixation-strength="2">例8<br-bold><br-fixation fixation-strength="1">因严重的<br-fixation fixation-strength="2">不自主运<br-fixation fixation-strength="3">动不能配<br-fixation fixation-strength="4">合<br-edge>完成PSG)<br-bold><br-fixation fixation-strength="1">均接<br-fixation fixation-strength="2">受了<br-fixation fixation-strength="3">PS<br-fixation fixation-strength="4"><br-edge>G检查。<br-bold><br-fixation fixation-strength="1">结<br-fixation fixation-strength="2">果<br-fixation fixation-strength="3">表<br-edge>明,<br-bold><br-fixation fixation-strength="1">睡眠纺<br-fixation fixation-strength="2">锤体和<br-fixation fixation-strength="3">K复合<br-fixation fixation-strength="4">体<br-edge>早期减少,<br-bold><br-fixation fixation-strength="1">总睡<br-fixation fixation-strength="2">眠时<br-fixation fixation-strength="3">间<br-fixation fixation-strength="4"><br-edge>减少,<br-bold><br-fixation fixation-strength="1">睡<br-fixation fixation-strength="2">眠<br-fixation fixation-strength="3">效<br-fixation fixation-strength="4">率<br-edge>降低,<br-bold><br-fixation fixation-strength="1">正常<br-fixation fixation-strength="2">的睡<br-fixation fixation-strength="3">眠觉<br-fixation fixation-strength="4">醒周<br-edge>期障碍,<br-bold><br-fixation fixation-strength="1">尤其<br-fixation fixation-strength="2">是R<br-fixation fixation-strength="3">EM<br-fixation fixation-strength="4">期减<br-edge>少或缺失,<br-bold><br-fixation fixation-strength="1">RE<br-fixation fixation-strength="2">M的<br-fixation fixation-strength="3">睡眠<br-fixation fixation-strength="4">潜伏<br-edge>期延长。<br-bold><br-fixation fixation-strength="1">在<br-fixation fixation-strength="2">病<br-fixation fixation-strength="3">例3<br-bold><br-fixation fixation-strength="1">中,<br-bold><br-fixation fixation-strength="1">REM<br-fixation fixation-strength="2">睡眠直<br-fixation fixation-strength="3">接发生<br-fixation fixation-strength="4">在<br-edge>清醒状态。<br-bold><br-fixation fixation-strength="1">PSG还发<br-fixation fixation-strength="2">现了所有F<br-fixation fixation-strength="3">FI患者均<br-fixation fixation-strength="4">出现睡眠呼<br-edge>吸暂停低通气事件,<br-bold><br-fixation fixation-strength="1">其特征<br-fixation fixation-strength="2">是NR<br-fixation fixation-strength="3">EM期<br-fixation fixation-strength="4">的阻塞<br-edge>性呼吸暂停、<br-bold><br-fixation fixation-strength="1">低<br-fixation fixation-strength="2">通<br-fixation fixation-strength="3">气<br-fixation fixation-strength="4">和<br-edge>喉鸣。<br-bold><br-fixation fixation-strength="1">我<br-fixation fixation-strength="2">们<br-fixation fixation-strength="3">观<br-fixation fixation-strength="4">察<br-edge>到这9<br-bold><br-fixation fixation-strength="1">位患者<br-fixation fixation-strength="2">在睡眠<br-fixation fixation-strength="3">中的非<br-fixation fixation-strength="4"><br-edge>自主运动,<br-bold><br-fixation fixation-strength="1">大部分<br-fixation fixation-strength="2">在NR<br-fixation fixation-strength="3">EM阶<br-fixation fixation-strength="4"><br-edge>段第二期。9<br-bold><br-fixation fixation-strength="1">例FFI<br-fixation fixation-strength="2">患者的睡<br-fixation fixation-strength="3">眠结构图<br-fixation fixation-strength="4">分析提<br-edge>示睡眠效率降低,<br-bold><br-fixation fixation-strength="1">正常的<br-fixation fixation-strength="2">睡眠觉<br-fixation fixation-strength="3">醒周期<br-fixation fixation-strength="4">性<br-edge>形成障碍。<br-bold><br-fixation fixation-strength="1">结论<br-fixation fixation-strength="2">通过<br-fixation fixation-strength="3">分析<br-fixation fixation-strength="4"><br-edge>总结10<br-bold><br-fixation fixation-strength="1">例F<br-fixation fixation-strength="2">FI<br-fixation fixation-strength="3">患者<br-fixation fixation-strength="4"><br-edge>特点,<br-bold><br-fixation fixation-strength="1">将F<br-fixation fixation-strength="2">FI<br-fixation fixation-strength="3">核心<br-fixation fixation-strength="4">临床<br-edge>特征分为3<br-bold><br-fixation fixation-strength="1">组:(1)<br-bold><br-fixation fixation-strength="1">器质<br-fixation fixation-strength="2">性睡<br-fixation fixation-strength="3">眠<br-fixation fixation-strength="4"><br-edge>障碍:<br-bold><br-fixation fixation-strength="1">如<br-fixation fixation-strength="2">失<br-fixation fixation-strength="3">眠、<br-bold><br-fixation fixation-strength="1">深<br-fixation fixation-strength="2">睡<br-fixation fixation-strength="3">眠<br-fixation fixation-strength="4">缺<br-edge>失、<br-bold><br-fixation fixation-strength="1">片<br-fixation fixation-strength="2">段<br-fixation fixation-strength="3">睡<br-edge>眠、<br-bold><br-fixation fixation-strength="1">RE<br-fixation fixation-strength="2">M睡<br-fixation fixation-strength="3">眠减<br-fixation fixation-strength="4">少<br-edge>或缺失、<br-bold><br-fixation fixation-strength="1">喉<br-fixation fixation-strength="2">鸣、<br-bold><br-fixation fixation-strength="1">睡眠<br-fixation fixation-strength="2">呼吸<br-fixation fixation-strength="3">障碍<br-fixation fixation-strength="4">和不<br-edge>自主运动；(2)<br-bold><br-fixation fixation-strength="1">神<br-fixation fixation-strength="2">经<br-fixation fixation-strength="3">精<br-fixation fixation-strength="4">神<br-edge>症状:<br-bold><br-fixation fixation-strength="1">快速<br-fixation fixation-strength="2">进展<br-fixation fixation-strength="3">的<br-fixation fixation-strength="4"><br-edge>痴呆,<br-bold><br-fixation fixation-strength="1">伴或<br-fixation fixation-strength="2">不伴<br-fixation fixation-strength="3">有共<br-fixation fixation-strength="4"><br-edge>济失调、<br-bold><br-fixation fixation-strength="1">锥体<br-fixation fixation-strength="2">束征<br-fixation fixation-strength="3">或锥<br-fixation fixation-strength="4">体外<br-edge>系症状/<br-bold><br-fixation fixation-strength="1">体<br-fixation fixation-strength="2">征,<br-bold><br-fixation fixation-strength="1">精<br-fixation fixation-strength="2">神<br-fixation fixation-strength="3">症<br-edge>状；(3)<br-bold><br-fixation fixation-strength="1">进展<br-fixation fixation-strength="2">性交<br-fixation fixation-strength="3">感神<br-fixation fixation-strength="4"><br-edge>经症状:<br-bold><br-fixation fixation-strength="1">包<br-fixation fixation-strength="2">括<br-fixation fixation-strength="3">高<br-fixation fixation-strength="4">血<br-edge>压,<br-bold><br-fixation fixation-strength="1">出<br-fixation fixation-strength="2">汗,<br-bold><br-fixation fixation-strength="1">心<br-fixation fixation-strength="2">动<br-fixation fixation-strength="3">过<br-edge>速,<br-bold><br-fixation fixation-strength="1">呼<br-fixation fixation-strength="2">吸<br-fixation fixation-strength="3">不<br-fixation fixation-strength="4">规<br-edge>律、<br-bold><br-fixation fixation-strength="1">构<br-fixation fixation-strength="2">音<br-fixation fixation-strength="3">障<br-fixation fixation-strength="4">碍<br-edge>等。<br-bold><br-fixation fixation-strength="1">家族中出<br-fixation fixation-strength="2">现快速进<br-fixation fixation-strength="3">展的痴呆<br-fixation fixation-strength="4">和<br-edge>失眠的阳性史,<br-bold><br-fixation fixation-strength="1">PSG提示特征性<br-fixation fixation-strength="2">表现以及SPEC<br-fixation fixation-strength="3">T或PET显像提<br-fixation fixation-strength="4">示丘脑葡萄糖代谢<br-edge>减低为FFI诊断的提示性特征。<br-bold><br-fixation fixation-strength="1">根据<br-fixation fixation-strength="2">FF<br-fixation fixation-strength="3">I患<br-fixation fixation-strength="4">者的<br-edge>临床特征、<br-bold><br-fixation fixation-strength="1">家族<br-fixation fixation-strength="2">史以<br-fixation fixation-strength="3">及实<br-fixation fixation-strength="4">验室<br-edge>检查结果,<br-bold><br-fixation fixation-strength="1">将F<br-fixation fixation-strength="2">FI<br-fixation fixation-strength="3">诊断<br-fixation fixation-strength="4"><br-edge>分为3<br-bold><br-fixation fixation-strength="1">种<br-fixation fixation-strength="2">层<br-fixation fixation-strength="3">级:<br-bold><br-fixation fixation-strength="1">可<br-fixation fixation-strength="2">能<br-fixation fixation-strength="3">的<br-fixation fixation-strength="4">F<br-edge>FI,<br-bold><br-fixation fixation-strength="1">很可能<br-fixation fixation-strength="2">的FF<br-fixation fixation-strength="3">I及确<br-fixation fixation-strength="4">诊<br-edge>的FFI。<br-bold><br-fixation fixation-strength="1">如出<br-fixation fixation-strength="2">现躯<br-fixation fixation-strength="3">体相<br-fixation fixation-strength="4">关睡<br-edge>眠障碍((1)<br-bold><br-fixation fixation-strength="1">组<br-fixation fixation-strength="2">症<br-fixation fixation-strength="3">状)+1<br-bold><br-fixation fixation-strength="1">或2<br-bold><br-fixation fixation-strength="1">项其<br-fixation fixation-strength="2">他核<br-fixation fixation-strength="3">心<br-fixation fixation-strength="4"><br-edge>特征((2)/(3)<br-bold><br-fixation fixation-strength="1">组)<br-bold><br-fixation fixation-strength="1">诊断<br-fixation fixation-strength="2">可能<br-fixation fixation-strength="3">的F<br-fixation fixation-strength="4"><br-edge>FI；<br-bold><br-fixation fixation-strength="1">如果提<br-fixation fixation-strength="2">示性特<br-fixation fixation-strength="3">征中出<br-fixation fixation-strength="4">现一<br-edge>项或多项,<br-bold><br-fixation fixation-strength="1">且出现<br-fixation fixation-strength="2">以上两<br-fixation fixation-strength="3">项或以<br-fixation fixation-strength="4">上<br-edge>核心特征((1)/(2)/(3)<br-bold><br-fixation fixation-strength="1">组<br-fixation fixation-strength="2">症<br-fixation fixation-strength="3">状),<br-bold><br-fixation fixation-strength="1">则可<br-fixation fixation-strength="2">诊断<br-fixation fixation-strength="3">为很<br-fixation fixation-strength="4">可能<br-edge>的FFI；<br-bold><br-fixation fixation-strength="1">如果<br-fixation fixation-strength="2">朊蛋<br-fixation fixation-strength="3">白<br-fixation fixation-strength="4"><br-edge>基因(<br-bold><br-fixation fixation-strength="1">R<br-fixation fixation-strength="2">P<br-fixation fixation-strength="3">N<br-edge>P)<br-bold><br-fixation fixation-strength="1">检测<br-fixation fixation-strength="2">结果<br-fixation fixation-strength="3">为<br-fixation fixation-strength="4"><br-edge>阳性,<br-bold><br-fixation fixation-strength="1">则可<br-fixation fixation-strength="2">确诊<br-fixation fixation-strength="3">F<br-fixation fixation-strength="4"><br-edge>FI。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=89766683504849574854485451
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 2



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">基于多模<br-fixation fixation-strength="2">态MRI<br-fixation fixation-strength="3">数据的早<br-fixation fixation-strength="4">期帕金森<br-edge>病影像特征分析
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">雷<br-fixation fixation-strength="2">冠<br-fixation fixation-strength="3">雄
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">胡<br-fixation fixation-strength="2">芳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">谭<br-fixation fixation-strength="2">东<br-fixation fixation-strength="3">辉
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">吴<br-fixation fixation-strength="2">涛
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">朱<br-fixation fixation-strength="2">晟
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">刘<br-fixation fixation-strength="2">东
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">彭<br-fixation fixation-strength="2">国<br-fixation fixation-strength="3">茳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">何<br-fixation fixation-strength="2">玉<br-fixation fixation-strength="3">成
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">邓<br-fixation fixation-strength="2">忠
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">湘<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">学<br-edge>院,<br-bold><br-fixation fixation-strength="1">湖<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">郴<br-edge>州423000
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">湘南<br-fixation fixation-strength="2">学院<br-fixation fixation-strength="3">附属<br-fixation fixation-strength="4"><br-edge>医院,<br-bold><br-fixation fixation-strength="1">湖<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">郴<br-edge>州423000
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">医学影<br-fixation fixation-strength="2">像人工<br-fixation fixation-strength="3">智能湖<br-fixation fixation-strength="4">南省<br-edge>重点实验室,<br-bold><br-fixation fixation-strength="1">湖<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">郴<br-edge>州423000
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">郴州市听<br-fixation fixation-strength="2">觉与言语<br-fixation fixation-strength="3">疾病诊疗<br-fixation fixation-strength="4">技<br-edge>术研发中心,<br-bold><br-fixation fixation-strength="1">湖<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">郴<br-edge>州423000
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">郴州市认<br-fixation fixation-strength="2">知退化脑<br-fixation fixation-strength="3">疾病预警<br-fixation fixation-strength="4">技<br-edge>术研发中心,<br-bold><br-fixation fixation-strength="1">湖<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">郴<br-edge>州423000
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">湘南<br-fixation fixation-strength="2">学院<br-fixation fixation-strength="3">第一<br-fixation fixation-strength="4">附<br-edge>属医院,<br-bold><br-fixation fixation-strength="1">湖<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">郴<br-edge>州423000
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1673-498<br-bold><br-fixation fixation-strength="1">X
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">湘<br-fixation fixation-strength="2">南<br-fixation fixation-strength="3">学<br-fixation fixation-strength="4">院<br-edge>学报（<br-bold><br-fixation fixation-strength="1">医<br-fixation fixation-strength="2">学<br-fixation fixation-strength="3">版）
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2021
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 23
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 3
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 1-5
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">帕<br-fixation fixation-strength="2">金<br-fixation fixation-strength="3">森<br-edge>病
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">磁<br-fixation fixation-strength="2">共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4">成<br-edge>像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">多<br-fixation fixation-strength="2">模<br-fixation fixation-strength="3">态<br-fixation fixation-strength="4">成<br-edge>像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">特<br-fixation fixation-strength="2">征
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目的<br-fixation fixation-strength="2">分析<br-fixation fixation-strength="3">早期<br-fixation fixation-strength="4">帕<br-edge>金森病(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">D)<br-bold><br-fixation fixation-strength="1">患者多模<br-fixation fixation-strength="2">态MRI<br-fixation fixation-strength="3">成像方式<br-fixation fixation-strength="4">下<br-edge>的影像特征,<br-bold><br-fixation fixation-strength="1">为PD<br-fixation fixation-strength="2">的发病<br-fixation fixation-strength="3">机制研<br-fixation fixation-strength="4">究提供<br-edge>影像学支撑。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法29<br-bold><br-fixation fixation-strength="1">例早<br-fixation fixation-strength="2">期帕<br-fixation fixation-strength="3">金森<br-fixation fixation-strength="4"><br-edge>病患者(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">D<br-fixation fixation-strength="3">组)<br-bold><br-fixation fixation-strength="1">和30<br-bold><br-fixation fixation-strength="1">例<br-fixation fixation-strength="2">健<br-fixation fixation-strength="3">康<br-fixation fixation-strength="4">志<br-edge>愿者(<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">C<br-fixation fixation-strength="3">组)<br-bold><br-fixation fixation-strength="1">被<br-fixation fixation-strength="2">纳<br-fixation fixation-strength="3">入<br-fixation fixation-strength="4">研<br-edge>究,<br-bold><br-fixation fixation-strength="1">分别<br-fixation fixation-strength="2">进行<br-fixation fixation-strength="3">MR<br-fixation fixation-strength="4"><br-edge>I扫描,<br-bold><br-fixation fixation-strength="1">获<br-fixation fixation-strength="2">取<br-fixation fixation-strength="3">T1<br-bold><br-fixation fixation-strength="1">加<br-fixation fixation-strength="2">权<br-fixation fixation-strength="3">像(<br-bold><br-fixation fixation-strength="1">T1<br-bold><br-fixation fixation-strength="1">W<br-fixation fixation-strength="2">I)、<br-bold><br-fixation fixation-strength="1">弥<br-fixation fixation-strength="2">散<br-fixation fixation-strength="3">张<br-fixation fixation-strength="4">量<br-edge>成像(<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">T<br-fixation fixation-strength="3">I)、<br-bold><br-fixation fixation-strength="1">功能<br-fixation fixation-strength="2">磁共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4"><br-edge>成像(<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-edge>I)<br-bold><br-fixation fixation-strength="1">等多<br-fixation fixation-strength="2">个模<br-fixation fixation-strength="3">态<br-fixation fixation-strength="4"><br-edge>图像,<br-bold><br-fixation fixation-strength="1">经预<br-fixation fixation-strength="2">处理<br-fixation fixation-strength="3">后提<br-fixation fixation-strength="4">取<br-edge>特征值,<br-bold><br-fixation fixation-strength="1">统计<br-fixation fixation-strength="2">两组<br-fixation fixation-strength="3">差异<br-fixation fixation-strength="4">显著<br-edge>的脑区。<br-bold><br-fixation fixation-strength="1">结果<br-fixation fixation-strength="2">与H<br-fixation fixation-strength="3">C组<br-fixation fixation-strength="4"><br-edge>比较,<br-bold><br-fixation fixation-strength="1">PD<br-fixation fixation-strength="2">组多<br-fixation fixation-strength="3">个脑<br-fixation fixation-strength="4">区<br-edge>出现T1<br-bold><br-fixation fixation-strength="1">体素值<br-fixation fixation-strength="2">或DT<br-fixation fixation-strength="3">I各向<br-fixation fixation-strength="4"><br-edge>异性分数(<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">值)<br-bold><br-fixation fixation-strength="1">显<br-fixation fixation-strength="2">著<br-fixation fixation-strength="3">减<br-edge>少(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">两<br-fixation fixation-strength="2">组<br-fixation fixation-strength="3">被<br-fixation fixation-strength="4">试<br-edge>有12<br-bold><br-fixation fixation-strength="1">个脑<br-fixation fixation-strength="2">区的<br-fixation fixation-strength="3">fM<br-fixation fixation-strength="4">RI<br-edge>聚类系数(<br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">p<br-fixation fixation-strength="3">值)<br-bold><br-fixation fixation-strength="1">差异<br-fixation fixation-strength="2">有统<br-fixation fixation-strength="3">计学<br-fixation fixation-strength="4"><br-edge>意义(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">双侧<br-fixation fixation-strength="2">中央<br-fixation fixation-strength="3">后回<br-fixation fixation-strength="4"><br-edge>在T1<br-bold><br-fixation fixation-strength="1">W<br-fixation fixation-strength="2">I、<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">T<br-fixation fixation-strength="3">I、<br-bold><br-fixation fixation-strength="1">f<br-fixation fixation-strength="2">M<br-fixation fixation-strength="3">R<br-edge>I 3<br-bold><br-fixation fixation-strength="1">种模<br-fixation fixation-strength="2">态下<br-fixation fixation-strength="3">均出<br-fixation fixation-strength="4">现显<br-edge>著性改变(<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="1">结论<br-fixation fixation-strength="2">在P<br-fixation fixation-strength="3">D<br-fixation fixation-strength="4"><br-edge>早期,<br-bold><br-fixation fixation-strength="1">大脑灰<br-fixation fixation-strength="2">质体积<br-fixation fixation-strength="3">已出现<br-fixation fixation-strength="4"><br-edge>显著萎缩,<br-bold><br-fixation fixation-strength="1">相应脑<br-fixation fixation-strength="2">白质纤<br-fixation fixation-strength="3">维束的<br-fixation fixation-strength="4">完<br-edge>整性破坏,<br-bold><br-fixation fixation-strength="1">脑功<br-fixation fixation-strength="2">能网<br-fixation fixation-strength="3">络整<br-fixation fixation-strength="4">体结<br-edge>构稳定,<br-bold><br-fixation fixation-strength="1">但局<br-fixation fixation-strength="2">部结<br-fixation fixation-strength="3">构已<br-fixation fixation-strength="4">遭<br-edge>到破坏；<br-bold><br-fixation fixation-strength="1">躯体感觉<br-fixation fixation-strength="2">障碍可能<br-fixation fixation-strength="3">是PD早<br-fixation fixation-strength="4">期<br-edge>出现的改变,<br-bold><br-fixation fixation-strength="1">且<br-fixation fixation-strength="2">症<br-fixation fixation-strength="3">状<br-fixation fixation-strength="4">稳<br-edge>定。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7105981161
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 0
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">湖南<br-fixation fixation-strength="2">省自<br-fixation fixation-strength="3">然科<br-fixation fixation-strength="4">学基<br-edge>金项目(2020<br-bold><br-fixation fixation-strength="1">J<br-fixation fixation-strength="2">J8034,2020<br-bold><br-fixation fixation-strength="1">J<br-fixation fixation-strength="2">J5524)；<br-bold><br-fixation fixation-strength="1">湖南省<br-fixation fixation-strength="2">临床医<br-fixation fixation-strength="3">疗技术<br-fixation fixation-strength="4">创新<br-edge>引导项目(2018<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">K52002,2018<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">K52004,2020<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">K52202)；<br-bold><br-fixation fixation-strength="1">湖南<br-fixation fixation-strength="2">省教<br-fixation fixation-strength="3">育厅<br-fixation fixation-strength="4">科<br-edge>研项目(20<br-bold><br-fixation fixation-strength="1">A459,19<br-bold><br-fixation fixation-strength="1">B526,18<br-bold><br-fixation fixation-strength="1">B504)；<br-bold><br-fixation fixation-strength="1">郴州<br-fixation fixation-strength="2">市科<br-fixation fixation-strength="3">技计<br-fixation fixation-strength="4"><br-edge>划项目(<br-bold><br-fixation fixation-strength="1">z<br-fixation fixation-strength="2">d<br-fixation fixation-strength="3">y<br-edge>f2020180,<br-bold><br-fixation fixation-strength="1">z<br-fixation fixation-strength="2">d<br-fixation fixation-strength="3">y<br-edge>f201906,<br-bold><br-fixation fixation-strength="1">z<br-fixation fixation-strength="2">d<br-fixation fixation-strength="3">y<br-edge>f201809)。



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">勘<br-fixation fixation-strength="2">误<br-fixation fixation-strength="3">声<br-edge>明
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">磁共<br-fixation fixation-strength="2">振成<br-fixation fixation-strength="3">像编<br-fixation fixation-strength="4"><br-edge>辑部
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">不<br-fixation fixation-strength="2">详
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 1674-8034
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">磁<br-fixation fixation-strength="2">共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4">成<br-edge>像
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2021
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 12
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 9
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 112-112
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">度<br-fixation fixation-strength="2">中<br-fixation fixation-strength="3">心<br-edge>性
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">勘<br-fixation fixation-strength="2">误
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">静<br-fixation fixation-strength="2">息<br-fixation fixation-strength="3">态
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">编<br-fixation fixation-strength="2">校
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">期<br-fixation fixation-strength="2">刊
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">由<br-fixation fixation-strength="2">于<br-fixation fixation-strength="3">编<br-fixation fixation-strength="4">校<br-edge>疏忽,<br-bold><br-fixation fixation-strength="1">本<br-fixation fixation-strength="2">刊2021<br-bold><br-fixation fixation-strength="1">年<br-fixation fixation-strength="2">第12<br-bold><br-fixation fixation-strength="1">卷<br-fixation fixation-strength="2">第7<br-bold><br-fixation fixation-strength="1">期<br-fixation fixation-strength="2">刊<br-fixation fixation-strength="3">发<br-edge>的《<br-bold><br-fixation fixation-strength="1">基于低频振幅<br-fixation fixation-strength="2">分数和度中心<br-fixation fixation-strength="3">性的躯体症状<br-fixation fixation-strength="4">障碍静息<br-edge>态回行功能成像研究》(<br-bold><br-fixation fixation-strength="1">第<br-fixation fixation-strength="2">一<br-fixation fixation-strength="3">作<br-edge>者:<br-bold><br-fixation fixation-strength="1">崔<br-fixation fixation-strength="2">阳<br-fixation fixation-strength="3">阳)<br-bold><br-fixation fixation-strength="1">一<br-fixation fixation-strength="2">文<br-fixation fixation-strength="3">题<br-fixation fixation-strength="4">目<br-edge>有误。<br-bold><br-fixation fixation-strength="1">该文<br-fixation fixation-strength="2">题目<br-fixation fixation-strength="3">应<br-fixation fixation-strength="4"><br-edge>改为:<br-bold><br-fixation fixation-strength="1">基于低频振幅<br-fixation fixation-strength="2">分数和度中心<br-fixation fixation-strength="3">性的躯体症状<br-fixation fixation-strength="4">障碍静<br-edge>息态脑功能成像研究。<br-bold><br-fixation fixation-strength="1">特向作<br-fixation fixation-strength="2">者和读<br-fixation fixation-strength="3">者致以<br-fixation fixation-strength="4">诚<br-edge>挚的歉意!
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7105646372
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 0



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">顶<br-fixation fixation-strength="2">叶<br-fixation fixation-strength="3">外<br-fixation fixation-strength="4">侧<br-edge>癫痫——<br-bold><br-fixation fixation-strength="1">解<br-fixation fixation-strength="2">剖、<br-bold><br-fixation fixation-strength="1">生<br-fixation fixation-strength="2">理<br-fixation fixation-strength="3">与<br-fixation fixation-strength="4">临<br-edge>床
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">王<br-fixation fixation-strength="2">薇<br-fixation fixation-strength="3">薇
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">吴<br-fixation fixation-strength="2">逊
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">北京<br-fixation fixation-strength="2">大学<br-fixation fixation-strength="3">第一<br-fixation fixation-strength="4">医院<br-edge>神经内科,<br-bold><br-fixation fixation-strength="1">北<br-fixation fixation-strength="2">京100034
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 2096-0247
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">癫<br-fixation fixation-strength="2">痫<br-fixation fixation-strength="3">杂<br-edge>志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2023
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 9
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 2
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 134-141
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">顶<br-fixation fixation-strength="2">叶<br-fixation fixation-strength="3">癫<br-edge>痫
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">顶<br-fixation fixation-strength="2">上<br-fixation fixation-strength="3">小<br-edge>叶
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">顶<br-fixation fixation-strength="2">下<br-fixation fixation-strength="3">小<br-edge>叶
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">中<br-fixation fixation-strength="2">央<br-fixation fixation-strength="3">后<br-edge>回
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">外<br-fixation fixation-strength="2">科<br-fixation fixation-strength="3">治<br-edge>疗
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">顶叶为联<br-fixation fixation-strength="2">合皮质与<br-fixation fixation-strength="3">其他脑叶<br-fixation fixation-strength="4">有<br-edge>广泛的联系。<br-bold><br-fixation fixation-strength="1">顶叶癫<br-fixation fixation-strength="2">痫少见<br-fixation fixation-strength="3">仅为全<br-fixation fixation-strength="4"><br-edge>部癫痫的1.4%。<br-bold><br-fixation fixation-strength="1">因其无特<br-fixation fixation-strength="2">殊性症状<br-fixation fixation-strength="3">且迅速扩<br-fixation fixation-strength="4">布<br-edge>至其他脑叶,<br-bold><br-fixation fixation-strength="1">所以<br-fixation fixation-strength="2">发作<br-fixation fixation-strength="3">症状<br-fixation fixation-strength="4"><br-edge>复杂,<br-bold><br-fixation fixation-strength="1">临<br-fixation fixation-strength="2">床<br-fixation fixation-strength="3">诊<br-fixation fixation-strength="4">断<br-edge>困难。<br-bold><br-fixation fixation-strength="1">具<br-fixation fixation-strength="2">有<br-fixation fixation-strength="3">躯<br-fixation fixation-strength="4">体<br-edge>感觉、<br-bold><br-fixation fixation-strength="1">体<br-fixation fixation-strength="2">象<br-fixation fixation-strength="3">障<br-edge>碍、<br-bold><br-fixation fixation-strength="1">前庭<br-fixation fixation-strength="2">感觉<br-fixation fixation-strength="3">这三<br-fixation fixation-strength="4"><br-edge>种先兆,<br-bold><br-fixation fixation-strength="1">发作源<br-fixation fixation-strength="2">于顶叶<br-fixation fixation-strength="3">的可能<br-fixation fixation-strength="4"><br-edge>性非常大。<br-bold><br-fixation fixation-strength="1">发作性<br-fixation fixation-strength="2">症状多<br-fixation fixation-strength="3">类似额<br-fixation fixation-strength="4">叶或<br-edge>颞叶发作。<br-bold><br-fixation fixation-strength="1">头皮<br-fixation fixation-strength="2">脑电<br-fixation fixation-strength="3">图定<br-fixation fixation-strength="4">位意<br-edge>义不大,<br-bold><br-fixation fixation-strength="1">因此多<br-fixation fixation-strength="2">需要颅<br-fixation fixation-strength="3">内电极<br-fixation fixation-strength="4">监测<br-edge>以及影像学[<br-bold><br-fixation fixation-strength="1">如<br-fixation fixation-strength="2">磁<br-fixation fixation-strength="3">共<br-fixation fixation-strength="4">振<br-edge>成像(<br-bold><br-fixation fixation-strength="1">Ma<br-fixation fixation-strength="2">gn<br-fixation fixation-strength="3">et<br-fixation fixation-strength="4"><br-edge>ic <br-bold><br-fixation fixation-strength="1">re<br-fixation fixation-strength="2">so<br-fixation fixation-strength="3">na<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">im<br-fixation fixation-strength="2">ag<br-fixation fixation-strength="3">i<br-fixation fixation-strength="4"><br-edge>ng, <br-bold><br-fixation fixation-strength="1">M<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">I),<br-bold><br-fixation fixation-strength="1">发作时<br-fixation fixation-strength="2">单光子<br-fixation fixation-strength="3">发射计<br-fixation fixation-strength="4">算机<br-edge>断层成像术(<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4">g<br-edge>le-<br-bold><br-fixation fixation-strength="1">p<br-fixation fixation-strength="2">h<br-fixation fixation-strength="3">o<br-fixation fixation-strength="4">t<br-edge>on <br-bold><br-fixation fixation-strength="1">em<br-fixation fixation-strength="2">is<br-fixation fixation-strength="3">si<br-fixation fixation-strength="4"><br-edge>on <br-bold><br-fixation fixation-strength="1">co<br-fixation fixation-strength="2">mp<br-fixation fixation-strength="3">ut<br-fixation fixation-strength="4"><br-edge>ed <br-bold><br-fixation fixation-strength="1">to<br-fixation fixation-strength="2">mo<br-fixation fixation-strength="3">gr<br-fixation fixation-strength="4">a<br-edge>phy,<br-bold><br-fixation fixation-strength="1">S<br-fixation fixation-strength="2">P<br-fixation fixation-strength="3">E<br-fixation fixation-strength="4">C<br-edge>T)]<br-bold><br-fixation fixation-strength="1">检<br-fixation fixation-strength="2">测。<br-bold><br-fixation fixation-strength="1">顶叶癫<br-fixation fixation-strength="2">痫几乎<br-fixation fixation-strength="3">均为药<br-fixation fixation-strength="4">物难<br-edge>治性发作,<br-bold><br-fixation fixation-strength="1">定位<br-fixation fixation-strength="2">明确<br-fixation fixation-strength="3">的外<br-fixation fixation-strength="4"><br-edge>科治疗60%~80%<br-bold><br-fixation fixation-strength="1">预<br-fixation fixation-strength="2">后<br-fixation fixation-strength="3">良<br-edge>好。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=7109289134
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 0



<br-span>{<br-bold><br-fixation fixation-strength="1">Re<br-fixation fixation-strength="2">fe<br-fixation fixation-strength="3">re<br-fixation fixation-strength="4"><br-edge>nce <br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">y<br-fixation fixation-strength="3">p<br-edge>e}: <br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al <br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le
<br-span>{<br-bold><br-fixation fixation-strength="1">T<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">l<br-edge>e}: <br-bold><br-fixation fixation-strength="1">首发抑<br-fixation fixation-strength="2">郁症患<br-fixation fixation-strength="3">者纹状<br-fixation fixation-strength="4">体<br-edge>多巴胺D2<br-bold><br-fixation fixation-strength="1">受体结合<br-fixation fixation-strength="2">力改变及<br-fixation fixation-strength="3">其与行为<br-fixation fixation-strength="4">学<br-edge>的相关分析
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">孙<br-fixation fixation-strength="2">萌<br-fixation fixation-strength="3">萌
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">张<br-fixation fixation-strength="2">红<br-fixation fixation-strength="3">菊
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">轩<br-fixation fixation-strength="2">昂
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">张<br-fixation fixation-strength="2">杰
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">付<br-fixation fixation-strength="2">畅
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">尤<br-fixation fixation-strength="2">阳
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">高<br-fixation fixation-strength="2">永<br-fixation fixation-strength="3">举
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">史<br-fixation fixation-strength="2">大<br-fixation fixation-strength="3">鹏
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or}: <br-bold><br-fixation fixation-strength="1">徐<br-fixation fixation-strength="2">俊<br-fixation fixation-strength="3">玲
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">郑州大学<br-fixation fixation-strength="2">人民医院<br-fixation fixation-strength="3">暨河南省<br-fixation fixation-strength="4">人<br-edge>民医院PET-<br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">T<br-fixation fixation-strength="3">中<br-edge>心,450003
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">郑州大学<br-fixation fixation-strength="2">人民医院<br-fixation fixation-strength="3">暨河南省<br-fixation fixation-strength="4">人民<br-edge>医院神经内科,450003
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">郑州大学<br-fixation fixation-strength="2">人民医院<br-fixation fixation-strength="3">暨河南省<br-fixation fixation-strength="4">人民<br-edge>医院核医学科,450003
<br-span>{<br-bold><br-fixation fixation-strength="1">A<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">h<br-edge>or <br-bold><br-fixation fixation-strength="1">Ad<br-fixation fixation-strength="2">dr<br-fixation fixation-strength="3">e<br-fixation fixation-strength="4"><br-edge>ss}: <br-bold><br-fixation fixation-strength="1">郑州大学<br-fixation fixation-strength="2">人民医院<br-fixation fixation-strength="3">暨河南省<br-fixation fixation-strength="4">人<br-edge>民医院放射科,450003
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">B<br-edge>N/<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">S<br-fixation fixation-strength="3">S<br-edge>N}: 2095-2848
<br-span>{<br-bold><br-fixation fixation-strength="1">Jo<br-fixation fixation-strength="2">ur<br-fixation fixation-strength="3">n<br-fixation fixation-strength="4"><br-edge>al}: <br-bold><br-fixation fixation-strength="1">中华<br-fixation fixation-strength="2">核医<br-fixation fixation-strength="3">学与<br-fixation fixation-strength="4">分子<br-edge>影像杂志
<br-span>{<br-bold><br-fixation fixation-strength="1">Y<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">a<br-edge>r}: 2017
<br-span>{<br-bold><br-fixation fixation-strength="1">V<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">l<br-fixation fixation-strength="4">u<br-edge>me}: 37
<br-span>{<br-bold><br-fixation fixation-strength="1">I<br-fixation fixation-strength="2">s<br-fixation fixation-strength="3">s<br-fixation fixation-strength="4">u<br-edge>e}: 9
<br-span>{<br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">a<br-fixation fixation-strength="3">g<br-fixation fixation-strength="4">e<br-edge>s}: 532-537
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">抑<br-fixation fixation-strength="2">郁<br-fixation fixation-strength="3">症
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">纹<br-fixation fixation-strength="2">状<br-fixation fixation-strength="3">体
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">受<br-fixation fixation-strength="2">体,<br-bold><br-fixation fixation-strength="1">多<br-fixation fixation-strength="2">巴<br-fixation fixation-strength="3">胺
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">正电<br-fixation fixation-strength="2">子发<br-fixation fixation-strength="3">射断<br-fixation fixation-strength="4">层<br-edge>显像术
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">体<br-fixation fixation-strength="2">层<br-fixation fixation-strength="3">摄<br-fixation fixation-strength="4">影<br-edge>术,<br-bold><br-fixation fixation-strength="1">X<br-fixation fixation-strength="2">线<br-fixation fixation-strength="3">计<br-fixation fixation-strength="4">算<br-edge>机
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">磁<br-fixation fixation-strength="2">共<br-fixation fixation-strength="3">振<br-fixation fixation-strength="4">成<br-edge>像
<br-span>{<br-bold><br-fixation fixation-strength="1">Ke<br-fixation fixation-strength="2">yw<br-fixation fixation-strength="3">or<br-fixation fixation-strength="4"><br-edge>ds}: <br-bold><br-fixation fixation-strength="1">雷<br-fixation fixation-strength="2">氯<br-fixation fixation-strength="3">必<br-edge>利
<br-span>{<br-bold><br-fixation fixation-strength="1">Ab<br-fixation fixation-strength="2">st<br-fixation fixation-strength="3">ra<br-fixation fixation-strength="4"><br-edge>ct}: <br-bold><br-fixation fixation-strength="1">目<br-fixation fixation-strength="2">的<br-fixation fixation-strength="3">应<br-edge>用11<br-bold><br-fixation fixation-strength="1">C-<br-bold><br-fixation fixation-strength="1">雷<br-fixation fixation-strength="2">氯<br-fixation fixation-strength="3">必<br-edge>利（<br-bold><br-fixation fixation-strength="1">Ra<br-fixation fixation-strength="2">cl<br-fixation fixation-strength="3">op<br-fixation fixation-strength="4">r<br-edge>ide） <br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">E<br-fixation fixation-strength="3">T/<br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">T，<br-bold><br-fixation fixation-strength="1">结合<br-fixation fixation-strength="2">汉密<br-fixation fixation-strength="3">尔顿<br-fixation fixation-strength="4">抑<br-edge>郁量表（<br-bold><br-fixation fixation-strength="1">H<br-fixation fixation-strength="2">A<br-fixation fixation-strength="3">M-<br-bold><br-fixation fixation-strength="1">D），<br-bold><br-fixation fixation-strength="1">探讨首<br-fixation fixation-strength="2">发抑郁<br-fixation fixation-strength="3">症患者<br-fixation fixation-strength="4">纹状<br-edge>体多巴胺D2<br-bold><br-fixation fixation-strength="1">受体<br-fixation fixation-strength="2">的受<br-fixation fixation-strength="3">体结<br-fixation fixation-strength="4"><br-edge>合力（<br-bold><br-fixation fixation-strength="1">B<br-fixation fixation-strength="2">P<br-fixation fixation-strength="3">N<br-edge>D）<br-bold><br-fixation fixation-strength="1">改变及<br-fixation fixation-strength="2">其与行<br-fixation fixation-strength="3">为学改<br-fixation fixation-strength="4">变之<br-edge>间的关系。<br-bold><br-fixation fixation-strength="1">方<br-fixation fixation-strength="2">法<br-fixation fixation-strength="3">以2014<br-bold><br-fixation fixation-strength="1">年12<br-bold><br-fixation fixation-strength="1">月<br-fixation fixation-strength="2">至2015<br-bold><br-fixation fixation-strength="1">年12<br-bold><br-fixation fixation-strength="1">月间收治<br-fixation fixation-strength="2">的首发抑<br-fixation fixation-strength="3">郁症患者<br-fixation fixation-strength="4">及<br-edge>与患者年龄、<br-bold><br-fixation fixation-strength="1">性别相匹<br-fixation fixation-strength="2">配的健康<br-fixation fixation-strength="3">志愿者为<br-fixation fixation-strength="4">对象进<br-edge>行前瞻性研究，<br-bold><br-fixation fixation-strength="1">所有受<br-fixation fixation-strength="2">试者均<br-fixation fixation-strength="3">接受脑<br-fixation fixation-strength="4">部<br-edge>MRI和11<br-bold><br-fixation fixation-strength="1">C-<br-bold><br-fixation fixation-strength="1">Ra<br-fixation fixation-strength="2">cl<br-fixation fixation-strength="3">op<br-fixation fixation-strength="4">r<br-edge>ide <br-bold><br-fixation fixation-strength="1">P<br-fixation fixation-strength="2">E<br-fixation fixation-strength="3">T/<br-bold><br-fixation fixation-strength="1">C<br-fixation fixation-strength="2">T<br-fixation fixation-strength="3">检<br-edge>查。<br-bold><br-fixation fixation-strength="1">应用分<br-fixation fixation-strength="2">子影像<br-fixation fixation-strength="3">动态分<br-fixation fixation-strength="4"><br-edge>析工具箱（<br-bold><br-fixation fixation-strength="1">M<br-fixation fixation-strength="2">I<br-fixation fixation-strength="3">A<br-fixation fixation-strength="4">K<br-edge>AT）<br-bold><br-fixation fixation-strength="1">软件计<br-fixation fixation-strength="2">算受试<br-fixation fixation-strength="3">者纹状<br-fixation fixation-strength="4">体<br-edge>多巴胺D2<br-bold><br-fixation fixation-strength="1">受体<br-fixation fixation-strength="2">的B<br-fixation fixation-strength="3">P<br-fixation fixation-strength="4"><br-edge>ND，<br-bold><br-fixation fixation-strength="1">分析抑<br-fixation fixation-strength="2">郁症患<br-fixation fixation-strength="3">者纹状<br-fixation fixation-strength="4">体<br-edge>多巴胺D2<br-bold><br-fixation fixation-strength="1">受体<br-fixation fixation-strength="2">BP<br-fixation fixation-strength="3">ND<br-fixation fixation-strength="4"><br-edge>的改变，<br-bold><br-fixation fixation-strength="1">并对<br-fixation fixation-strength="2">BP<br-fixation fixation-strength="3">ND<br-fixation fixation-strength="4">与患<br-edge>者HAM-<br-bold><br-fixation fixation-strength="1">D评<br-fixation fixation-strength="2">分进<br-fixation fixation-strength="3">行相<br-fixation fixation-strength="4"><br-edge>关分析。<br-bold><br-fixation fixation-strength="1">采用<br-fixation fixation-strength="2">配对<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4"><br-edge>检验、<br-bold><br-fixation fixation-strength="1">两样本t<br-fixation fixation-strength="2">检验及P<br-fixation fixation-strength="3">ears<br-fixation fixation-strength="4">on相<br-edge>关分析处理数据。<br-bold><br-fixation fixation-strength="1">结果<br-fixation fixation-strength="2">共纳<br-fixation fixation-strength="3">入首<br-fixation fixation-strength="4">发抑<br-edge>郁症患者20<br-bold><br-fixation fixation-strength="1">例（<br-bold><br-fixation fixation-strength="1">抑<br-fixation fixation-strength="2">郁<br-fixation fixation-strength="3">组），<br-bold><br-fixation fixation-strength="1">其<br-fixation fixation-strength="2">中<br-fixation fixation-strength="3">男8<br-bold><br-fixation fixation-strength="1">例、<br-bold><br-fixation fixation-strength="1">女12<br-bold><br-fixation fixation-strength="1">例，<br-bold><br-fixation fixation-strength="1">平<br-fixation fixation-strength="2">均<br-fixation fixation-strength="3">年<br-edge>龄（32.80±9.76）<br-bold><br-fixation fixation-strength="1">岁；<br-bold><br-fixation fixation-strength="1">健<br-fixation fixation-strength="2">康<br-fixation fixation-strength="3">志<br-fixation fixation-strength="4">愿<br-edge>者20<br-bold><br-fixation fixation-strength="1">名（<br-bold><br-fixation fixation-strength="1">对<br-fixation fixation-strength="2">照<br-fixation fixation-strength="3">组），<br-bold><br-fixation fixation-strength="1">其<br-fixation fixation-strength="2">中<br-fixation fixation-strength="3">男9<br-bold><br-fixation fixation-strength="1">名、<br-bold><br-fixation fixation-strength="1">女11<br-bold><br-fixation fixation-strength="1">名，<br-bold><br-fixation fixation-strength="1">平<br-fixation fixation-strength="2">均<br-fixation fixation-strength="3">年<br-edge>龄（29.25±6.93）<br-bold><br-fixation fixation-strength="1">岁。<br-bold><br-fixation fixation-strength="1">抑郁组<br-fixation fixation-strength="2">和对照<br-fixation fixation-strength="3">组受试<br-fixation fixation-strength="4">者<br-edge>脑组织对^11<br-bold><br-fixation fixation-strength="1">C-<br-bold><br-fixation fixation-strength="1">Racl<br-fixation fixation-strength="2">opri<br-fixation fixation-strength="3">de摄取<br-fixation fixation-strength="4">均主要<br-edge>分布于纹状体区，<br-bold><br-fixation fixation-strength="1">大脑<br-fixation fixation-strength="2">皮质<br-fixation fixation-strength="3">和小<br-fixation fixation-strength="4">脑分<br-edge>布极微。<br-bold><br-fixation fixation-strength="1">抑郁<br-fixation fixation-strength="2">组双<br-fixation fixation-strength="3">侧尾<br-fixation fixation-strength="4"><br-edge>状核、<br-bold><br-fixation fixation-strength="1">壳<br-fixation fixation-strength="2">核<br-fixation fixation-strength="3">D2<br-bold><br-fixation fixation-strength="1">受体B<br-fixation fixation-strength="2">PND<br-fixation fixation-strength="3">差异无<br-fixation fixation-strength="4">统<br-edge>计学意义（<br-bold><br-fixation fixation-strength="1">t<br-fixation fixation-strength="2">值：0.69<br-bold><br-fixation fixation-strength="1">和0.35，<br-bold><br-fixation fixation-strength="1">均<br-fixation fixation-strength="2">P〉0.05）；<br-bold><br-fixation fixation-strength="1">对照<br-fixation fixation-strength="2">组双<br-fixation fixation-strength="3">侧尾<br-fixation fixation-strength="4"><br-edge>状核、<br-bold><br-fixation fixation-strength="1">壳<br-fixation fixation-strength="2">核<br-fixation fixation-strength="3">D2<br-bold><br-fixation fixation-strength="1">受体B<br-fixation fixation-strength="2">PND<br-fixation fixation-strength="3">差异无<br-fixation fixation-strength="4">统<br-edge>计学意义（<br-bold><br-fixation fixation-strength="1">t<br-fixation fixation-strength="2">值：0.28<br-bold><br-fixation fixation-strength="1">和0.24，<br-bold><br-fixation fixation-strength="1">均<br-fixation fixation-strength="2">P〉0.05）。<br-bold><br-fixation fixation-strength="1">抑郁<br-fixation fixation-strength="2">组双<br-fixation fixation-strength="3">侧尾<br-fixation fixation-strength="4"><br-edge>状核、<br-bold><br-fixation fixation-strength="1">壳<br-fixation fixation-strength="2">核<br-fixation fixation-strength="3">D2<br-bold><br-fixation fixation-strength="1">受体B<br-fixation fixation-strength="2">PND<br-fixation fixation-strength="3">均分别<br-fixation fixation-strength="4">低<br-edge>于对照组（<br-bold><br-fixation fixation-strength="1">t<br-fixation fixation-strength="2">值：3.13～4.41，<br-bold><br-fixation fixation-strength="1">均<br-fixation fixation-strength="2">P〈0.05）。<br-bold><br-fixation fixation-strength="1">抑郁<br-fixation fixation-strength="2">组双<br-fixation fixation-strength="3">侧尾<br-fixation fixation-strength="4"><br-edge>状核和（<br-bold><br-fixation fixation-strength="1">或）<br-bold><br-fixation fixation-strength="1">壳<br-fixation fixation-strength="2">核<br-fixation fixation-strength="3">D2<br-bold><br-fixation fixation-strength="1">受体<br-fixation fixation-strength="2">BP<br-fixation fixation-strength="3">ND<br-fixation fixation-strength="4">与<br-edge>HAM-<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">总<br-fixation fixation-strength="3">分、<br-bold><br-fixation fixation-strength="1">焦<br-fixation fixation-strength="2">虑<br-fixation fixation-strength="3">或<br-fixation fixation-strength="4">躯<br-edge>体化、<br-bold><br-fixation fixation-strength="1">认<br-fixation fixation-strength="2">知<br-fixation fixation-strength="3">障<br-edge>碍、<br-bold><br-fixation fixation-strength="1">迟滞及<br-fixation fixation-strength="2">睡眠障<br-fixation fixation-strength="3">碍等因<br-fixation fixation-strength="4">子分值<br-edge>均有相关性（<br-bold><br-fixation fixation-strength="1">r<br-fixation fixation-strength="2">值：－0.688～－0.453，<br-bold><br-fixation fixation-strength="1">均<br-fixation fixation-strength="2">P〈0.05）。<br-bold><br-fixation fixation-strength="1">结论首<br-fixation fixation-strength="2">发抑郁<br-fixation fixation-strength="3">症患者<br-fixation fixation-strength="4">纹状<br-edge>体多巴胺D2<br-bold><br-fixation fixation-strength="1">受体<br-fixation fixation-strength="2">BP<br-fixation fixation-strength="3">ND<br-fixation fixation-strength="4"><br-edge>下降，<br-bold><br-fixation fixation-strength="1">且<br-fixation fixation-strength="2">D2<br-bold><br-fixation fixation-strength="1">受体B<br-fixation fixation-strength="2">PND<br-fixation fixation-strength="3">水平与<br-fixation fixation-strength="4">抑郁<br-edge>症症状相关。<br-bold><br-fixation fixation-strength="1">纹状体多<br-fixation fixation-strength="2">巴胺受体<br-fixation fixation-strength="3">异常可能<br-fixation fixation-strength="4">是抑<br-edge>郁症患者中脑-<br-bold><br-fixation fixation-strength="1">纹状体多<br-fixation fixation-strength="2">巴胺奖赏<br-fixation fixation-strength="3">环路异常<br-fixation fixation-strength="4">的重要<br-edge>分子机制之一。
<br-span>{<br-bold><br-fixation fixation-strength="1">U<br-fixation fixation-strength="2">R<br-fixation fixation-strength="3">L}: <br-bold><br-fixation fixation-strength="1">h<br-fixation fixation-strength="2">t<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">p<br-edge>s://<br-bold><br-fixation fixation-strength="1">q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">q<br-fixation fixation-strength="3">v<br-fixation fixation-strength="4">i<br-edge>p.<br-bold><br-fixation fixation-strength="1">c<br-fixation fixation-strength="2">o<br-fixation fixation-strength="3">m/<br-bold><br-fixation fixation-strength="1">Q<br-fixation fixation-strength="2">i<br-fixation fixation-strength="3">k<br-fixation fixation-strength="4">a<br-edge>n/<br-bold><br-fixation fixation-strength="1">Ar<br-fixation fixation-strength="2">ti<br-fixation fixation-strength="3">c<br-fixation fixation-strength="4"><br-edge>le/<br-bold><br-fixation fixation-strength="1">D<br-fixation fixation-strength="2">e<br-fixation fixation-strength="3">t<br-fixation fixation-strength="4">a<br-edge>il?<br-bold><br-fixation fixation-strength="1">i<br-fixation fixation-strength="2">d=673203993
<br-span>{<br-bold><br-fixation fixation-strength="1">Da<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ba<br-fixation fixation-strength="4"><br-edge>se <br-bold><br-fixation fixation-strength="1">Pr<br-fixation fixation-strength="2">ov<br-fixation fixation-strength="3">id<br-fixation fixation-strength="4"><br-edge>er}: <br-bold><br-fixation fixation-strength="1">重庆<br-fixation fixation-strength="2">维普<br-fixation fixation-strength="3">资讯<br-fixation fixation-strength="4">有<br-edge>限公司
<br-span>{<br-bold><br-fixation fixation-strength="1">ci<br-fixation fixation-strength="2">ta<br-fixation fixation-strength="3">ti<br-fixation fixation-strength="4"><br-edge>ons}: 16
<br-span>{<br-bold><br-fixation fixation-strength="1">F<br-fixation fixation-strength="2">u<br-fixation fixation-strength="3">n<br-edge>d}: <br-bold><br-fixation fixation-strength="1">国家<br-fixation fixation-strength="2">自然<br-fixation fixation-strength="3">科学<br-fixation fixation-strength="4"><br-edge>基金（81271534）



